No constraints - 4x more data with 100% correlation

The Microhub enables you to simultaneously capture all 4 labels or different structures in a single acquisition for both widefield and confocal, without ever moving your sample. This overcomes the spatiotemporal mismatch between labels of moving objects during sequential acquisition.

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4 labels simultaneously | 4 labels 100% correlated | Patented FluoSync technology

3D Cell Culture, 7d spheroid formation of U343 cells. tfLC3 EGFP and mRFP + DAPI + WGA Alexa680. Objective: 20x NA 0.70 DRY

No constraints - Select the right modality in real time

Mica unifies transmitted and fluorescence light imaging modalities. You can select from multiple imaging modalities all within one Microhub, including widefield, confocal, THUNDER imaging, LIGHTNING, Z-stacks, time-lapse and more.

This enables you e.g., to generate fast overviews with widefield at low magnification, gradually zoom in on the regions of interest, and switch to confocal when and where needed without ever moving the sample to a different system.

  • Seamlessly move from fast overview to high resolution when required by your experiment
  • Switch from widefield to confocal mode with just a simple click without ever moving your sample

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Unified imaging modalities | Point scanning confocal

No constraints - Achieve physiological-like conditions thoughout your experiments

Live cell experiments require the cells to be in optimal shape. Typically, 2D and 3D cells in media require the temperature and the pH (via CO2) in the environment to be controlled. Stable nutrition and ion concentrations require the evaporation to be minimal. Some experiments even demand the O2 to be mimicked closer to physiological levels. Mica can provide the right conditions in the live cell configuration. 

  • Maintain your sample in optimal conditions and minimize evaporation

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Mica is an incubator

Formation of 3D spheroids from 1000 stably transfected MDCK MX1-GFP cells per well (left half) and 1000 U2OS cells per well (right half). Time-lapse acquisition over 60 hrs. with 30 minutes interval. Green, GFP. Gray, integrated modulation contrast.

U2OS cells were labelled with SiR-Actin, TMRE (mitochondria activity), CellEvent™ (caspase activity), and DAPI (nuclei). 63x magnification, widefield mode.

Radically simplified workflows

Intelligent automation and AI-supported analysis enables greater efficiency and a faster track to publication. 

  • Reduce over 60% of process steps through system intelligence
  • Reduce time and effort from sample to insight by simplifying your entire workflow
  • Enable 100% reproducibility and repeatability throughout your experiment

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Pixel classifier | GUI operated annotations | Reusable AI models and projects parameters

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Meet Mica in key applications

Fluorescence multi-well plate Assay

Mica allows you to image 4 labels simultaneously, with 100% spatiotemporal correlation.

This key application shows how Mica is used with fluorescent multi-well plate assays around Caspase 3/7 activations in apoptosis.

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U2OS cells were labelled with SiR-Actin, TMRE (mitochondria activity), CellEvent™ (caspase activity), and DAPI (nuclei). Apoptosis inducer staurosporine (3µM) was added at time-point 0. Widefield mode, 63x magnification. 13 hours time-lapse.

Meet Mica in key applications

3D Tissue Imaging

Mica enables you to seamlessly move from fast overview to high resolution when required by your experiment.

See how Mica allows you identify a detyrosynated tubulin positive cell and progress from overview to the segmentation of the tubulin network.

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Intestine tissue section acquired with 20x and 63x magnification, using widefield and confocal imaging. 20x widefield images are processed with THUNDER and 63x confocal images with LIGHTNING. Nuclei are labeled in blue, mitochondria in green, and detyrosynated tubulin in red.

Meet Mica in key applications

Long-term Time lapse

Mica is an incubator to maintain your sample in physiological-like conditions and to minimize evaporation.

Discover how Mica allows you to measure spheroids growth and to analyze protein expression levels.

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Formation of 3D spheroids from 1000 stably transfected MDCK MX1-GFP cells per well and 1000 U2OS cells per well shown at 5 different timepoints. Time-lapse acquisition over 60 hrs. with 30 minutes interval. Green, GFP. Gray, integrated modulation contrast.

The Microhub era is now!

Experience the future.

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