More than a highly automated microscope, Mica unites widefield and confocal imaging in a sample protecting, incubating environment. With the simple push of a button, you have everything you need - all in one place - to supercharge fluorescence imaging workflows and get meaningful scientific results faster.
We work with pancreatic cancer organoids so, whenever we find interesting structures and want to zoom in and have higher resolution, then, with basically one click, we can switch from the epifluorescence to confocal mode.
See Mica in action
Now you can focus on your science, not figuring out your microscope.
Everyone can now leverage microscopy to make more discoveries.
Mica provides a clear sample overview and allows to easily change observation conditions with just a few clicks.
85% fewer steps to the first image
33% less time to the first image
50% of the training time
Mouse embryo (E15.5) cryosection captured with the PL APO 20x/0.75 CS2 objective. Section shows Tbr2 cells labeled with CF488A, Satb2 cells labeled with CF555 and Ctip2 cells with CF633 plus nuclei counterstaining with DAPI. The acquisition of two sections took less than 5 minutes, while previously it took 2 hours on the lab’s comparison device. Sample and images are courtesy of Giulia Di Muzio at the lab of Dr. Pei-Chi Wei at the DKFZ, Heidelberg, Germany.
No constraints - 4x more data with 100% correlation
The Microhub enables you to simultaneously capture all 4 labels of different structures in a single acquisition for widefield or confocal, without ever moving your sample. This overcomes the spatiotemporal mismatch between labels of moving objects during sequential acquisition. All powered by our patented FluoSync technology, a fast and gentle method for multicolor fluorescence imaging.
No constraints - Select the right modality in real time
Mica unifies transmitted and fluorescence light imaging modalities. You can select from multiple imaging modalities all within one Microhub, including widefield, confocal, THUNDER imaging, LIGHTNING, Z-stacks, time-lapse and more.
This enables you to
generate fast overviews with widefield at low magnification
gradually zoom in on the regions of interest
switch to confocal when and where needed without ever moving the sample to a different system
3D Cell Culture, 7d spheroid formation of U343 cells. tfLC3 EGFP and mRFP + DAPI + WGA Alexa680. Objective: 20x NA 0.70 DRY
No constraints - Achieve physiological-like conditions thoughout your experiments
Live cell experiments require the cells to be in optimal shape. Typically, 2D and 3D cells in media require the temperature and the pH (via CO2) in the environment to be controlled. Stable nutrition and ion concentrations require the evaporation to be minimal. Some experiments even demand the O2 to be mimicked closer to physiological levels. Mica can provide the right conditions in the live cell configuration.
Mica is an incubator: the entire encapsulated inner sample space can be climate controlled (temperature, CO2 and humidity regulation) and offers ideal conditions for short and long-term live cell observation.
From dark to light: Mica also enables you to enjoy a brightly lit lab—freeing you from the constraints of sitting in a dark room for hours monitoring your experiment.
Formation of 3D spheroids from 1000 stably transfected MDCK MX1-GFP cells per well (left half) and 1000 U2OS cells per well (right half). Time-lapse acquisition over 60 hrs. with 30 minutes interval. Green, GFP. Gray, integrated modulation contrast.
