Mica Microhub
This changes everything.
Mica is available in 4 configurations, depending on whether you need confocal imaging in addition to widefield imaging, and whether you need to image live cells or just fixed samples.
Technical Specifications
x = included, o = optional, - = not available
Widefield Imaging | Widefield + Confocal Imaging | ||||
Fixed Samples | Fixed + Live Cells | Fixed Samples | Fixed + Live Cells | ||
Mica Widefield | Mica Widefield Live Cell | Mica WideFocal | Mica WideFocal Live Cell | ||
Illumination and Detection | |||||
| Transmitted light contrast | Integrated modulation contrast (IMC) automatically adjusted and brightfield contrast in RGB or gray scale mode | x | x | x | x |
| Incident fluorescence illumination | 4 x LEDs: 365 nm, 470 nm, 555 nm and 625 nm | x | x | x | x |
| Widefield detector type | 5 MP CMOS FluoSyncTM detector enabling 4 label simultaneous imaging | x | x | x | x |
| Confocal illumination | 4 x Laser diodes: 405 nm, 488 nm, 561 nm and 638 nm | - | - | x | x |
| Confocal detector type | HyD FS FluoSyncTM detector enabling 4 label simultaneous imaging | - | - | x | x |
Environmental Control | |||||
| Live cell package | Temp. (to 45°C), CO2 (0 - 10%), Humidity | - | x | - | x |
| Hypoxia upgrade | Temp. (to 45°C), O2 (1% to air), CO2 (0 – 10%), Humidity | - | o | - | o |
Objectives | |||||
| Included objectives | HC PL FLUOTAR 1.6x/0.05 HC PL FLUOTAR 10x/0.32 | x | x | x | x |
| Recommended objectives | HC PL APO 20x/0.75 CS2 HC PL APO 40x/1.30 OIL CS2 HC PL APO 40x/1.10 W CS2 motCORR HC PL APO 63x/1.40 OIL CS2 HC PL APO 63x/1.20 W CS2 motCORR HC PL FLUOTAR L 20x/0.60 motCORR | o | o | o | o |
Adaptive Immersion | |||||
| Immersion dispension (closed loop water dispenser) | Forming and maintaining water immersion for one objective is feedback controlled and does not require any interaction | - | x | - | x |
Microscope Focus | |||||
| Autofocus | Reflection-based Adaptive Focus Control (AFC) and image-based Autofocus for transmitted light and fluorescence images (can be combined with AFC). | x | x | x | x |
Image enhancement methods | |||||
| THUNDER | Including all THUNDER methods: Instant Computational Clearing (ICC) Small Volume Computational Clearing (SVCC) Large Volume Computational Clearing (LVCC) | x | x | x | x |
| LIGHTNING Basic | x | x | x | x | |
| LIGHTNING Expert | o | o | o | o | |
Vibration isolation | |||||
| Anti-vibration table | Isolates the imaging against vibrational disturbances in the environment | x | x | x | x |
Key Functionalities of Mica
x = included, o = optional, - = not available
Mica Widefield | Mica Widefield Live Cell | Mica WideFocal | Mica WideFocal Live Cell | ||
|---|---|---|---|---|---|
| Name | Description | ||||
| FluoSyncTM | FluoSyncTM detection hardware with fully integrated digital spectral hybrid unmixing for separation of up to 4 labels during simultaneous imaging in either widefield or confocal mode. | x | x | x | x |
| OneTouch | Sets all technical excitation and detection parameters according to the experimental demands. This can either be done automatically or with a single click on-demand. | x | x | x | x |
| Focusing | Keeps the sample in focus throughout the experiment with a simple selection from a choice of 3 focus strategies. | x | x | x | x |
| 3D Imaging | Allows acquisition of 3D volumes in widefield and confocal mode. | x | x | x | x |
| Mixed TL & WF | Combines transmitted light with widefield imaging. | x | x | x | x |
| Mixed TL & CLSM | Combines transmitted light with confocal imaging. | - | - | x | x |
| Sample Finder | Quickly and automatically generates an in-focus overview of the relevant sample areas. | x | x | x | x |
| Navigator | Powerful package including Assay Editor, Stitching and Mark and Find license. Uses overview for navigation and for defining positions and regions in any shape. Displays all acquired images in spatial relation to all other images. | x | x | x | x |
| Objective Collision Prevention | Prevents the objective from colliding with a microtiter plate to protect the objective and sample. | x | x | x | x |
| Learn & Results | Mica’s pixel classifier for 2D and maximum intensity projection analysis. Easy to train and directly integrated into LAS X, it generates fast, reproducible image segmentation and beautifully visualized results with full traceability of the data points to the source in the image. | x | x | x | x |
| Aivia Accelerate | Comprehensive, pre‑trained, deep learning–based analysis for well plates and for 2D–5D data. The intuitive AI driven image visualization, analysis, and interpretation platform enables rapid exploration of relationships between key variables in experiments with minimal setup and no coding required. | x | x | x | x |
Popular Configurations
Mica 20x LWD Objective with Service Installation20x long working distance objective for imaging on glass and plastic bottom carriers. To penetrate deeper into samples using everyday standard plastic-bottom multi well plates, this Long Working Distance (LWD) objective has been optimized for use with Mica. · No need to sacrifice image quality · No need for costly glass-bottom alternatives · Avoid the frustration of switching carriers and re-optimizing your sample preparation protocols Why is long working distance important? · Focus deeper, capturing clearer images even with thicker or non-adherent samples such as organoids, spheroids and zebrafish larvae · Get increased compatibility with high-skirt well plates · Improve access to outer wells of multi well plates Please note: This objective requires service installation to ensure correct installation and calibration. A half-day service visit by our expert team is added to ensure optimal performance and system compatibility.
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Mica Widefield Live Cell Microhub Automated MicroscopeSimplify advanced live cell and fluorescence imaging. Get reliable, expert level microscopy results faster with extensive intelligent automation, AI-supported analysis, and an interface designed for ease of use. Perform long-term live cell experiments up to 4x faster than traditional widefield systems, capturing events that may previously have been missed. Easily get quality images as Mica automatically corrects the focus during experiments. Minimise phototoxicity and maintain optimal cell health with full environmental control. Ideal for long-term live-cell studies at near physiological conditions. MICA BENEFITS: ACCESS FOR ALL: Mica requires minimal technical input and gives consistent results every time, so all lab members can leverage microscopy to make more discoveries. NO CONSTRAINTS: Get true simultaneous capture of up to four labels without spatiotemporal mismatch – at near-physiological conditions for live cells, or with fixed samples. RADICALLY SIMPLIFIED WORKFLOWS: Intelligent automation and AI-supported analysis of diverse samples, such as tissues on slides or well plates, enable greater efficiency and a faster track to publication.
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Mica Widefield Microhub Automated MicroscopeSimplify advanced fluorescence imaging through extensive intelligent automation, AI‑supported analysis, and an easy-to-use interface. Now all lab members can get expert microscopy results, regardless of experience. Ideal for exploration and high-throughput fluorescence imaging of fixed samples. MICA BENEFITS: ACCESS FOR ALL: Mica requires minimal technical input and gives consistent results every time, so all lab members can leverage microscopy to make more discoveries. NO CONSTRAINTS: Get true simultaneous capture of up to four labels for fast acquisitions. RADICALLY SIMPLIFIED WORKFLOWS: Intelligent automation and AI-supported analysis of diverse samples, such as tissues on slides or well plates, enable greater efficiency and a faster track to publication.
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Mica WideFocal Live Cell Microhub Automated MicroscopeCombine widefield and confocal imaging in an incubating environment and simplify advanced live cell and fluorescence imaging. Extensive intelligent automation, AI-supported analysis, and an easy-to-use interface help you achieve expert microscopy results without all the training. Perform long-term live cell experiments up to 4x faster than traditional widefield systems, capturing events that may previously have been missed. Easily get quality images as Mica automatically corrects the focus during experiments. Minimise phototoxicity and maintain optimal cell health with full environmental control. Ideal for long-term and dynamic live cell studies of organoids, spheroids, and 3D cultures. MICA BENEFITS: ACCESS FOR ALL: Mica requires minimal technical input and gives consistent results every time, so all lab members can leverage microscopy to make more discoveries. NO CONSTRAINTS: Visualize in widefield and switch effortlessly to confocal without ever moving your sample. Get true simultaneous capture of up to four labels without spatiotemporal mismatch – at near-physiological conditions for live cells, or with fixed samples. RADICALLY SIMPLIFIED WORKFLOWS: Intelligent automation and AI-supported analysis of diverse samples, such as tissues on slides or well plates, enable greater efficiency and a faster track to publication.
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Mica WideFocal Microhub Automated MicroscopeCombine widefield and confocal imaging in an easy-to-use platform and simplify advanced fluorescence imaging. By streamlining workflows and reducing complexity through intelligent automation, AI-supported analysis, you can get expert microscopy results without all the training. Ideal for high-resolution imaging of thick or complex samples. MICA BENEFITS: ACCESS FOR ALL: Mica requires minimal technical input and gives consistent results every time, so all lab members can leverage microscopy to make more discoveries. NO CONSTRAINTS : Visualize in widefield and switch effortlessly to confocal without ever moving your sample. Get true simultaneous capture of up to four labels for fast acquisitions. RADICALLY SIMPLIFIED WORKFLOWS: Intelligent automation and AI-supported analysis of diverse samples, such as tissues on slides or well plates, enable greater efficiency and a faster track to publication.
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