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Anna Pastucha

We work with pancreatic cancer organoids so, whenever we find interesting structures and want to zoom in and have higher resolution, then, with basically one click, we can switch from the epifluorescence to confocal mode.

Dr. Anna Pastucha, Light Microscopy Facility Manager, Center for Functional Protein Assemblies, Technical University of Munich, Germany

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No constraints - 4x more data with 100% correlation

The Microhub enables you to simultaneously capture all 4 labels of different structures in a single acquisition for widefield or confocal, without ever moving your sample. This overcomes the spatiotemporal mismatch between labels of moving objects during sequential acquisition. All powered by our patented FluoSync technology, a fast and gentle method for multicolor fluorescence imaging.

No constraints - Select the right modality in real time

Mica unifies transmitted and fluorescence light imaging modalities. You can select from multiple imaging modalities all within one Microhub, including widefield, confocal, THUNDER imaging, LIGHTNING, Z-stacks, time-lapse and more.

This enables you to

  • generate fast overviews with widefield at low magnification
  • gradually zoom in on the regions of interest
  • switch to confocal when and where needed without ever moving the sample to a different system
3D Cell Culture, 7d spheroid formation of U343 cells. tfLC3 EGFP and mRFP + DAPI + WGA Alexa680. Objective: 20x NA 0.70 DRY

No constraints - Achieve physiological-like conditions thoughout your experiments

Live cell experiments require the cells to be in optimal shape. Typically, 2D and 3D cells in media require the temperature and the pH (via CO2) in the environment to be controlled. Stable nutrition and ion concentrations require the evaporation to be minimal. Some experiments even demand the O2 to be mimicked closer to physiological levels. Mica can provide the right conditions in the live cell configuration. 

  • Mica is an incubator: the entire encapsulated inner sample space can be climate controlled (temperature, CO2 and humidity regulation) and offers ideal conditions for short and long-term live cell observation.
  • From dark to light: Mica also enables you to enjoy a brightly lit lab—freeing you from the constraints of sitting in a dark room for hours monitoring your experiment.
Formation of 3D spheroids from 1000 stably transfected MDCK MX1-GFP cells per well (left half) and 1000 U2OS cells per well (right half). Time-lapse acquisition over 60 hrs. with 30 minutes interval. Green, GFP. Gray, integrated modulation contrast.

Radically simplified workflows

Intelligent automation and AI-supported analysis enables greater efficiency and a faster track to publication. 

  • Reduce over 60% of process steps through system intelligence
  • Reduce time and effort from sample to insight by simplifying your entire workflow
  • Enable 100% reproducibility and repeatability throughout your experiment
U2OS cells were labelled with SiR-Actin, TMRE (mitochondria activity), CellEvent™ (caspase activity), and DAPI (nuclei). 63x magnification, widefield mode.
U2OS cells were labelled with SiR-Actin, TMRE (mitochondria activity), CellEvent™ (caspase activity), and DAPI (nuclei). 63x magnification, widefield mode.
Developing Zebrafish embryo

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