Intravital Microscopy of Cancer

Webinar On-Demand

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Join our guest speaker Prof Dr Jacco van Rheenen, as he presents his work on the identity, behavior and fate of cells that drive the initiation and progression of cancer.

The van Rheenen group has developed techniques to visualize individual cells in real-time in whole bodies - intravital microscopy. Such cell populations are rare and change over time, so the ability to image them in this way uncovers multiple important factors within the single cell heterogeneity crucial to tissue homeostasis, tumor initiation and tumor progression.

Speaker: Prof. Dr. Jacco van Rheenen

Jacco van Rheenen originally trained in a variety of imaging techniques during his PhD with Dr. Kees Jalink at the Netherlands Cancer Institute. He was among the first to optimize imaging and develop software to quantitatively measure FRET on confocal microscopes. To widen his horizons, he obtained a KWF postdoc fellowship with Dr. John Condeelis at the Albert Einstein College of Medicine, USA. There he extended his imaging experience by imaging mammary tumors intravitally including two-photon microscopy and became an expert in the field of intravital FRET imaging.

In 2008 he became a group leader at the Hubrecht Institute, where he visualizes processes that are required for the metastasis of tumor cells in living animals. In July 2014 he was appointed professor in Intravital Microscopy at the University Medical Center Utrecht. In October 2017 he became senior group leader at the Netherlands Cancer Institute (NKI)  and the Oncode Institute.

In 2009, he was awarded a VIDI award from Netherlands Organization for Scientific Research.
In 2013, he received the Stem Cells Young Investigator Award.
In 2015, he was awarded an ERC consolidator grant
In 2017, he received the Dr. Josef Steiner Cancer Research Foundation Award
In 2019, he was given the Ammodo Science Award.

Key Learnings

Find out how intravital microscopy:

  • investigates the identity and migratory behaviour of cancer stem cells
  • gives valuable insight into cancer cell development, tissue homeostasis, tumor growth, and metastasis
  • uses multiphoton confocal microscopy to uncover key details in this important research

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