Three-dimensional organization of the mitotic spindle together with the distribution of CENP-C and BUB1 based on TauSTED with multiple STED lines (592, 660 and 775 nm) can provide insights on kinetochore assembly.
*Details of how this sample is used to understand kinetochore assembly can be read in Sacristan, C. et al. Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis. Nat. Cell Biol. 20, 800–810(2018). https://pubmed.ncbi.nlm.nih.gov/29915359/
Application note in nature.com: Pushing STED beyond its limits with TauSTED
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