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Life Science Research
Life Science Research
Leica Microsystems’ life science research microscopes support the imaging needs of the scientific community with advanced innovation and technical expertise for the visualization, measurement and analysis of microstructures.
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Life Science Research
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Read our latest articles about Life Science Research
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments.
How Fluorescence Guides Sectioning of Resin-embedded EM Samples
Electron microscopes, including transmission electron microscopes (TEM) and scanning electron microscopes (SEM), are widely utilized to gain detailed structural information about biological samples or non-living materials. Ultramicrotomy is the preferred technique for producing ultrathin sections, less than 100 nm thick for TEM/SEM analysis. During sample preparation small sample pieces are embedded in epoxy or acrylic resin, excess resin is trimmed away, and the specimen is sliced into ultrathin sections (50 nm - 100 nm) using a glass or diamond knife.
Coherent Raman Scattering Microscopy Publication List
CRS (Coherent Raman Scattering) microscopy is an umbrella term for label-free methods that image biological structures by exploiting the characteristic, intrinsic vibrational contrast of their molecules. The two most important CRS techniques are Coherent Anti-Stokes Raman Scattering (CARS) and Stimulated Raman Scattering (SRS). The biochemical image contrast of CRS is in many ways complementary to the molecular contrast obtained in fluorescence microscopy. A second crucial advantage of these methods is that they preserve the specimen/sample in a near pristine state. This reference list presents current and basic papers on CRS microscopy.
Selecting the Right Dissecting Microscope
Learn how you can enhance dissection for life-science research and education with a microscope that ensures ergonomic comfort, high-quality optics, and easy access to the specimen.
Get to Insights Faster and Easier with AI Image Analysis Tools
Discover how Aivia helps scientists streamline image analysis with fast setup, accurate AI detection, and easy batch processing.
Designing the Future with Novel and Scalable Stem Cell Culture
Visionary biotech start-up Uncommon Bio is tackling one of the world’s biggest health challenges: food sustainability. In this webinar, Stem Cell Scientist Samuel East shows how they make stem cell culture media for cellular agriculture safe and economically viable. See how they achieved a 1000x reduction in media costs and developed animal free, food safe iPSC culture media.
Explore Alzheimer's Spatial Proteome with Big Data
Alzheimer's disease, a genetic and sporadic neurodegenerative condition, leads to cognitive decline in mid to late life, marked by β-amyloid plaques and tau tangles. With limited treatment options, new investigative strategies are crucial. The Cell DIVE multiplexed imaging solution allows examination of Alzheimer's brain tissue, potentially uncovering new research avenues. Here, we showcase the Cell DIVE image viewer, enabling users to access the full Alzheimer's multiplexed dataset directly in their browser.
Mica: A Game-changer for Collaborative Research at Imperial College London
This interview highlights the transformative impact of Mica at Imperial College London. Scientists explain how Mica has been a game-changer, expanding research possibilities and facilitating interdisciplinary collaboration. They explain how detailed live cell imaging with Mica provides more meaningful information, keeping scientists at the forefront of research. The team foresees Mica continuing to open new research avenues, including the study of microfluidics and other advanced applications.
From Bench to Beam: A Complete Correlative Cryo Light Microscopy Workflow
In the webinar entitled "A Multimodal Vitreous Crusade, a Cryo Correlative Workflow from Bench to Beam" a team of experts discusses the exciting world of correlative workflows for structural biology that empower researchers to study fine details of biological structures. Watch and explore the latest developments, instruments, and techniques in cryo workflows for correlative light electron microscopy (cryo-CLEM).
Dive into Pancreatic Cancer Research with Big Data
Pancreatic cancer, with a mortality rate near 40%, is challenging to treat due to its proximity to major organs. This story explores the complex biology of pancreatic ductal adenocarcinoma (PDAC), examining molecular and spatial determinants of tumor aggression in metabolism, apoptosis, and immunity. Access the full Cell DIVE dataset in your browser to delve deeper into these findings.
Uncover the Hidden Complexity of Colon Cancer with Big Data
Colorectal cancer poses a significant health burden. While surgery is effective initially, some patients develop recurrent secondary disease with poor prognosis, necessitating advanced therapies like immunotherapies. Spatial biology approaches, such as multiplexed imaging with Cell DIVE, can provide crucial insights for developing novel treatments. Access the full Cell DIVE dataset in your browser to explore these findings further through the Minerva image viewer.
Introduction to 21 CFR Part 11 for Electronic Records of Cell Culture
This article provides an introduction to the recommendations of 21 CFR Part 11 from the FDA, specifically focusing on the audit trail and user management in the context of cell-culture laboratories. It is intended for professionals in the biotechnology and pharmaceutical industries who are responsible for ensuring agreement with 21 CFR part 11 for electronic records and electronic signatures. A digital microscope approach, e.g. with Mateo FL, offers the advantage of more consistent and efficient electronic documentation of cell-culture results compared to a paper-based method.
A Guide to Neuroscience Research
Are you working towards a better understanding of neurodegenerative diseases or studying the function of the nervous system? See how you can make breakthroughs with imaging solutions from Leica Microsystems.
Mapping Tumor Immune Landscape with AI-Powered Spatial Proteomics
Spatial mapping of untreated tumors provides an overview of the tumor immune architecture, useful for understanding therapeutic responses. Immunocompetent murine models are essential for identifying immune-dependent events in tumor development and progression. Characterizing these models, with intact immune systems and interacting cellular components, requires a multiplexed approach. We show an AI-powered spatial proteomics approach to study the tumor-immune interactions in murine cancer tissue.
A Guide to Zebrafish Research
For the best result during screening, sorting, manipulation, and imaging you need to see details and structures to make the right decisions for your next steps in research.
Known for outstanding optics and superb resolution, stereo microscopes and transmitted light bases from Leica are the preferred choice of researchers worldwide.
How to Automatically Obtain Fluorescent Cells of Interest in a Block-face
Block-face created by automatic trimming under fluorescence.
Mammalian cells of interest, stained with CellTrackerTM Green are visualized within the block-face using the UC Enuity equipped with the stereo microscope M205 FA. In the background a carbon finder grid in black is visible.
Deep Visual Proteomics Provides Precise Spatial Proteomic Information
Despite the availability of imaging methods and mass spectroscopy for spatial proteomics, a key challenge that remains is correlating images with single-cell resolution to protein-abundance measurements. Deep Visual Proteomics (DVP), a recent method, combines artificial-intelligence-driven image analysis of cellular phenotypes with automated single-cell or single-nucleus laser microdissection and ultra-high-sensitivity mass spectrometry. DVP links protein abundance to complex cellular or subcellular phenotypes while preserving spatial context.
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Microscopes and Imaging systems for Life Science Research 30
DM4 B & DM6 B
Enhance your life-science and clinical research with the DM4 B and DM6 B upright microscopes. With flexible software solutions, they allow you to focus on experiments while reducing manual work.
Mica
Mica - The world’s first Microhub. Everything you need to enable discoveries, unified in one easy-to-use system. Simultaneous 4-color widefield, confocal resolution, AI supported analysis.
LED Fluorescence Light Sources
Bright, stable, and versatile illumination for fluorescence imaging of routine cell culture, tissue sections, or advanced experiments with our LED series.
Latest Life Science Research News
The Sanderson Center for Optical Experimentation (SCOPE) at UMass Chan Medical School and Leica Microsystems, Inc. have collaborated to establish the…
Leica Microsystems has announced an exciting new collaboration with the Department of Biochemistry at The University of Oxford UK, in the fields of…
Leica Microsystems unveils next generation STELLARIS with SpectraPlex.
Putting customers first, building partnerships, and adapting to change with a continuous improvement mindset will continue to shape the company's path…
Aivia 14 offers complete multiplexed 3D spatial analysis workflow from cell detection to phenotyping and data exploration
Leica Microsystems announces the official launch of its Partner Excellence Program (PEP) for leading channel partners who outperformed regional growth…
Handling cybersecurity risks in a systemic and transparent way
Patented Viventis light sheet solution enables detailed volumetric imaging to explore life in its entirety
UC Enuity is the next generation ultramicrotome that saves users valuable time through its advanced features and automated-setup functions providing…
Power to see more with improved resolution and light dose balance
The Sanderson Center for Optical Experimentation (SCOPE) at UMass Chan Medical School and Leica Microsystems, Inc. have collaborated to establish the…
Leica Microsystems has announced an exciting new collaboration with the Department of Biochemistry at The University of Oxford UK, in the fields of…
Leica Microsystems unveils next generation STELLARIS with SpectraPlex.
Putting customers first, building partnerships, and adapting to change with a continuous improvement mindset will continue to shape the company's path…
Aivia 14 offers complete multiplexed 3D spatial analysis workflow from cell detection to phenotyping and data exploration
