Upright Light Microscopes

Upright microscopes for life science research

Get the publication-quality imaging and customizable upright microscope solution you need for your Life Science research with Leica Microsystems. These powerful imaging systems feature constant color, natural light illumination, superior optics, and configurable options to provide high contrast, brilliant images for your cutting-edge biological research.

Upright microscopes for industrial and materials

Get insights into the smallest details and inspect and document results efficiently with industrial and materials upright microscopes from Leica Microsystems. Each solution can be customized with brilliant, cool LED illumination, ergonomic accessories, sophisticated digital cameras and intuitive software to meet a broad range of applications.

Need Assistance?

Contact a local imaging specialist for expert advice on the right upright microscope for your needs and budget.

DM4 B & DM6 B Upright Microscopes

Rapid results, customized workflows, and deep insights. Optimized for imaging tissue and plant specimens, as well as pathology, these microscopes are designed to accelerate and tailor your workflows.

DM4 B & DM6 B

Read our latest articles about Upright Microscopes

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments.

Fixed patient-derived neuroendocrine tumor organoids labeled with DAPI (cyan) and phalloidin (magenta), imaged using Viventis SCAPE; scale bar 50μm. Courtesy of Marina Cuenca and Heleen Jungen (Dayton lab), EMBL Barcelona.

What’s the Best Organoid Imaging Approach for Early Drug Discovery?

Organoids and other complex in vitro models (CIVMs) are becoming increasingly important in early drug discovery and translational research, driven by the need for more predictive, human-relevant data…

Waffle method lamella preparation and cryo-ET results - Representative workflow and results of lamella preparation from a vitrified C. elegans L1 larva using the waffle method. Image courtesy: Prof. Dr. Jürgen M. Plitzko - doi.org/10.1038/s41592-023-02113-5-

Waffle Method Workflow: From HPF to Cryo-ET Lamellae

Waffle freezing provides an HPF-based route to cryo-ET sample preparation. This workflow guide follows the process from grid and carrier assembly to vitrification, cryo-FIB milling, lamella…

Large field of view (FOV) 2D slices of a 1 mm diameter midbrain neural organoid stained with DAPI (blue, nuclear stain), β-tubulin (green, neuronal stain), and GFAP (red, astrocyte stain). Acquired on THUNDER Imager Cell with 10x magnification. Left: Raw widefield image, Right: THUNDER cleared image. Scale bar 400 μm. Sample courtesy of Dr Tanya Singh, University of Oxford, UK.

Fast, High-Contrast Widefield Imaging of Optically Challenging Samples

Live‑cell imaging of large, complex biological samples often requires large fields of view, sub-cellular resolution, high-sensitivity, and fast acquisition – all while maintaining low illumination…

Hunched working position without a microscope (left) and upright neutral posture achieved with the M320 dental microscope (right).

Dental Loupes vs Microscopes: Exploring Visualization Options in Dentistry

Dental professionals often ask: “Should I use dental loupes or invest in a microscope?” This article explores the key differences between dental microscopes and dental loupes, focusing on…

Low-input spatial proteomics workflow for megakaryocyte isolation from bone marrow.

Spatial Proteomics Workflow in Blood Cancer (MPNs)

Megakaryocytes play a central role in the biology of myeloproliferative neoplasms (MPNs), yet their in vivo proteomic characterization remains a major challenge due to low abundance and disrupted…

Six Features to Consider when Choosing a Dental Microscope

The dental surgical microscope has become increasingly important for high-quality and successful dental medicine, particularly in the field of endodontics. A dentist can conduct micro-invasive…

Long-term in toto imaging of FUCCI2 intestinal organoids.

Multiscale Imaging of Organoids: High Content to Light Sheet

Learn multiscale organoid imaging: fixed high content phenotyping, gentle dual view light sheet, and reproducible pipelines that turn 3D data into insights.

Ribbon diagram of a donor (D) and acceptor (A) molecule which participate in FRET (Förster resonance energy transfer).

What is FRET with FLIM or as it is usually known FLIM-FRET?

Förster resonance energy transfer (FRET) is a well-established fluorescence-based technique which is used to study molecular interactions. It is useful for the analysis of protein-DNA and…

Time-lapse imaging of calcium in cells using the ratiometric calcium indicator Fura-2.

Ratiometric Imaging and Analysis of Ion Concentration in Cells

Many cellular functions depend on the dynamic balance of ions, electric potentials, and pH between the cytosol and surrounding extracellular space. Changes in these values affect cellular function.…

Proveo 8x 3D digital microscope used in ophthalmic surgery, illustrating heads‑up visualization and clinical collaboration.

4 Key Benefits of 3D Digital Microscopy in Ophthalmic Surgery

3D digital visualization is rapidly transforming ophthalmic surgery. Modern 3D surgical microscopes enable surgeons to perform procedures using high-resolution digital displays rather than traditional…

Materials Science and Inspection

Excellent sample preparation and imaging methods are key for inspecting materials and visualizing the fine details with reliability and accuracy. Inverted microscopes enable you to achieve this goal in a more efficient way compared to upright microscopes. They offer you high-quality optics and intelligent automation for optimal workflows.

Life Science Research

Inverted microscopes are often used in life science research for the visualization, measurement, analysis, and documentation of live cell and tissue cultures. Continuous innovative technical advances for inverted microscopes support the ever-changing imaging needs of life science researchers.

Interested to know more?
Talk to our experts.

Price

I need a configuration or price info.

Demo

I need an on site or remote demo.

Service & Repair

I need help keeping my system running: technical service, repairs, spare parts, upgrades or software licenses.

Application Support

I need assistance/training in how to operate my system properly, or how to run a specific application with my system.

Do you prefer personal consulting? Show local contacts