Upright Light Microscopes

Upright microscopes for life science research

Get the publication-quality imaging and customizable upright microscope solution you need for your Life Science research with Leica Microsystems. These powerful imaging systems feature constant color, natural light illumination, superior optics, and configurable options to provide high contrast, brilliant images for your cutting-edge biological research.

Upright microscopes for industrial and materials

Get insights into the smallest details and inspect and document results efficiently with industrial and materials upright microscopes from Leica Microsystems. Each solution can be customized with brilliant, cool LED illumination, ergonomic accessories, sophisticated digital cameras and intuitive software to meet a broad range of applications.

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DM4 B & DM6 B Upright Microscopes

Rapid results, customized workflows, and deep insights. Optimized for imaging tissue and plant specimens, as well as pathology, these microscopes are designed to accelerate and tailor your workflows.

DM4 B & DM6 B

Read our latest articles about Upright Microscopes

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments.

Cell DIVE multiplexed image of FFPE tissue section from human invasive ductal carcinoma (IDC)

AI-Powered Hi-Plex Spatial Analysis Tools for Breast Cancer Research

Breast cancer (BC) is the leading cause of cancer-related deaths in women. Investigating the tumor microenvironment (TME) is crucial to elucidate the mechanisms of tumor progression. Systematic…

67-hour, multi-position time-lapse of mouse intestinal organoids expressing the cell cycle reporter FUCCI2 (hGem-mVenus and hCdt1-mCherry).

Focus on Long-Term Imaging in 3D with Light Sheet Microscopy

Long-term 3D imaging reveals how complex multicellular systems grow and develop and how cells move and interact over time, unlocking critical insights into development, disease, and regeneration.…

Aneurysm shown with GLOW800 AR fluorescence application. Image courtesy of Prof. Jacques Guyotat, Hôpital Neurologique Pierre Wertheimer, Lyon

How AR Fluorescence Imaging Supports Neurovascular Surgery

In this article, we explain how fluorescence imaging works in vascular neurosurgery and explain the benefits of the GLOW800 Augmented Reality fluorescence application.

TEM micrographs of polymer sections. Left: Poly(styrene)-b-poly(isoprene). Right: Poly(styrene)-b-poly(methyl methacrylate).

Ultramicrotome Sectioning of Polymers for TEM Analysis

We demonstrate the capabilities of the UC Enuity ultramicrotome from Leica Microsystems for preparing ultrathin sections of polymer samples under both ambient and cryogenic conditions. By presenting…

Radially grown sugar crystals which have been imaged with a Leica microscope using circular polarized light.

Polarizing Microscope Image Gallery

How polarization microscope images can be used for analysis is shown in this gallery. Polarized light microscopy (also known as polarizing microscopy) is an important method for different fields and…

Artificial Intelligence (AI) segmentation used in conjunction with LMD to increase discovery throughput.

Biomarker Discovery with Laser Microdissection

Explore the potential of spatial proteomics workflows, such as Deep Visual Proteomics (DVP), to decipher pathology mechanisms and uncover druggable targets. Altered protein expression, abundance, or…

Brain organoid labeled with lamin (green) and tubulin (magenta), acquired using Viventis Deep. Courtesy of Akanksha Jain, Treutlein Lab ETH-DBSSE Basel (Switzerland).

Faster & Deeper Insights into Organoid and Spheroid Models

Gain deeper, more translatable, insights into organoid and spheroid models for drug discovery and disease research by overcoming key imaging challenges. In this eBook, explore advanced microscopy…

Final Segmentation of organelles in Trichomonas species. Magenta – costa, light blue – hydrogenosomes, turquoise – ER, red – vacuoles, yellow – axostyle, green – Golgi apparatus. Sample courtesy of Isabelle Guerin-Bonne, Low Kay En, Electron Microscopy Unit, Yong Loo Lin School of Medicine, National University of Singapore. Scale bar: 1 µm.

Volume EM and AI Image Analysis

The article outlines a detailed workflow for studying biological tissues in three dimensions using volume-scanning electron microscopy (volume-SEM) combined with AI-assisted image analysis. The focus…

Image of roundworm C. elegans acquired with a M205 FA fluorescence automated stereo microscope in combination with Rottermann contrast. Areas labelled with mCherry are seen as reddish purple.

A Guide to C. elegans Research – Working with Nematodes

Efficient microscopy techniques for C. elegans research are outlined in this guide. As a widely used model organism with about 70% gene homology to humans, the nematode Caenorhabditis elegans (also…

Dr. Nordmann in conversation with Dr. Falk Schlaudraff, Manager Product Management Uprights (widefield/compound) at Leica Microsystems.

How a Breakthrough in Spatial Proteomics Saved Lives

Toxic epidermal necrolysis (TEN) is a rare but devastating reaction to common medications like antibiotics or gout treatments. It begins innocuously, often as a rash, but can escalate rapidly into…

Materials Science and Inspection

Excellent sample preparation and imaging methods are key for inspecting materials and visualizing the fine details with reliability and accuracy. Inverted microscopes enable you to achieve this goal in a more efficient way compared to upright microscopes. They offer you high-quality optics and intelligent automation for optimal workflows.

Life Science Research

Inverted microscopes are often used in life science research for the visualization, measurement, analysis, and documentation of live cell and tissue cultures. Continuous innovative technical advances for inverted microscopes support the ever-changing imaging needs of life science researchers.

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