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Michael Smith , Ph.D.

Michael Smith

Michael Smith, Ph.D. is Application Manager for the Cell DIVE Multiplexed Imaging Solution at Leica Microsystems. He completed a Ph.D. in the genetics of DNA repair at Columbia University and a postdoctoral fellowship in genome integrity and cellular aging at Memorial Sloan Kettering Cancer Center, where he leveraged microscopy to understand the real-time dynamics of DNA homeostasis. His passion for answering biological questions using imaging technologies led him to his current position, where he provides technical expertise and customer support for the Cell DIVE platform.

Multi-tissue array with 4 markers shown including DAPI, NaKATPase, PanCk, and Vimentin.

Spatial Biology: Learning the Landscape

Spatial Biology: Understanding the organization and interaction of molecules, cells, and tissues in their native spatial context
Cell DIVE Multiplex Imaging Solution

Complex Made Simple: Antibodies in Multiplexed Imaging

Build panels, plan studies, and get the most from precious reagents using this antibody multiplexing guide from Leica Microsystems
Pancreatic Ductal Adenocarcinoma with 11 cancer immunity and progression biomarkers shown –CD3, CD4, CD20, CD31, CD45, Collagen, HLA1, NaKATPase, PCK26, SMA1, and Vimentin.

Open Multiplexing: Transforming Tissue Research with Cell DIVE

Watch this webinar to discover how open multiplexing adapts to meet the needs of your multiplexing imaging study.
Normal colon imaged with Cell DIVE. 8 biomarkers are shown: CD20, CD4, CD31, SOX9, Vimentin, Ki67, Panck and SMA.

Identifying Fibroblast Phenotypes with Multiplex Imaging

Identifying fibroblasts phenotypes can help researchers understand the relationship between distinct diseases and inflammation mechanisms. Fibroblasts perform a wide variety of immune and repair roles…
Pancreatic ductal adenocarcinoma tissue section imaged with Cell DIVE

Multiplexed Imaging Types, Benefits and Applications

Multiplexed imaging is an emerging and exciting way to extract information from human tissue samples by visualizing many more biomarkers than traditional microscopy. By observing many biomarkers…
Pancreatic ductal adenocarcinoma tissue section imaged with Cell DIVE showing 30 biomarkers

Multiplexed Imaging Glossary

Human tissues contain a many different biomarkers which can be explored to reveal the workings of biological pathways and interrogate disease states. Recent technological advances have made it…
Normal skin imaged with Cell DIVE, 11 biomarkers shown.

Tumor MHC Expression and Intralesional IL2 Response in Melanoma

Genomics profiling and Cell DIVE multiplex imaging allows researchers to understand the immune cell phenotypes that most strongly predict response to IL2 immunotherapy in melanoma patients suffering…
Colon Adenocarcinoma. Four biomarkers shown: NaK, CD8, CD4 and Sma1. T-Cells shown in red and yellow.

Multiplex Imaging Reveals Survival Markers after Cancer Care

Colorectal cancer is a high incidence and high mortality cancer. Currently, postoperative chemotherapy benefits only a minority of patients, and thus, new tools are necessary to screen patients and…
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