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  • A Versatile Palette of Fluorescent Probes

    Researchers at the Max Planck Institute for Medical Research in Heidelberg have developed a general strategy to synthesize live-cell compatible fluorogenic probes, and the result are the new MaP (Max…
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  • STED sheds insight on mitochondrial protein synthesis

    In this paper the authors have adapted a click chemistry-based method coupled with stimulated emission depletion nanoscopy (STED) to address these questions reporting that, in human cells in culture,…
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  • STED imaging of mitochondria revealed cristae dynamics during fusion. A comparison of confocal (left) and STED (right) imaging.

    Mitochondrial dynamics quantitatively revealed by STED nanoscopy

    Mitochondria are vital subcellular organelles, which can generate energy to support the entire lifecycle of biological cells. However, conventional fluorescence microscopy cannot provide a high enough…
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  • Benefits of Combining STED and Lifetime

    In this interview, Professor Alberto Diaspro talks about the advantages of the White Light Laser and the TauSTED capabilities of STELLARIS 8 STED. He speaks about his experience with the confocal…
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  • Download TauSTED Infographic

    TauSTED combines the optical signals from STED and the physical information from fluorescence lifetime at confocal speeds. Outstanding STED resolution and image quality is achieved due to background…
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  • Visualization of Submitochondrial Protein Distributions

    By allowing visualization of submitochondrial protein distributions, fluorescence nanoscopy offers significant advantages for understanding cell death control. How cells manage, and control…
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  • DNA Replication in Cancer Cells

    DNA synthesis can be impeded by collisions between the DNA replication machinery and co-transcriptional R-loops leading to a major source of genomic instability in cancer cells. In this paper we…
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  • Kinetochore Assembly during Mitosis with TauSTED on 3D

    Three-dimensional organization of the mitotic spindle together with the distribution of CENP-C and BUB1 based on TauSTED with multiple STED lines (592, 660 and 775 nm) can provide insights on…
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  • Fast 2 Colour Live Cell Dynamics with TauSTED Gentle Super-resolution

    TauSTED, with low photon budget and the fast detection scheme in our STELLARIS confocal platform, enables the tracking of highly dynamic processes in live cells. We can see in this example the…
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  • Regulators of Actin Cytoskeletal Regulation and Cell Migration in Human NK Cells

    Dr. Mace will describe new advances in our understanding of the regulation of human NK cell actin cytoskeletal remodeling in cell migration and immune synapse formation derived from confocal and…
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  • Benefits of TauContrast to Image Complex Samples

    In this interview, Dr. Timo Zimmermann talks about his experience with the application of TauSense tools and their potential for the investigation of demanding samples such as thick samples or…
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  • Upright Fluorescence Microscopy for Virus Replication Studies

    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread over the world quickly. Due to its dramatic impact, researchers are interested in the nature of the…
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  • Obtain maximum information from your specimen with LIGHTNING

    LIGHTNING is an adaptive process for extraction of information that reveals fine structures and details, otherwise simply not visible, fully automatically. Unlike traditional technologies, that use a…
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  • Fields of Application

  • Super-Resolution

    Find out more about Leica super-resolution microscopy solutions and how they can empower you to visualize in fine detail subcellular structures and dynamics.
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