Upright Light Microscopes

Upright microscopes for life science research

Get the publication-quality imaging and customizable upright microscope solution you need for your Life Science research with Leica Microsystems. These powerful imaging systems feature constant color, natural light illumination, superior optics, and configurable options to provide high contrast, brilliant images for your cutting-edge biological research.

Upright microscopes for industrial and materials

Get insights into the smallest details and inspect and document results efficiently with industrial and materials upright microscopes from Leica Microsystems. Each solution can be customized with brilliant, cool LED illumination, ergonomic accessories, sophisticated digital cameras and intuitive software to meet a broad range of applications.

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DM4 B & DM6 B Upright Microscopes

Rapid results, customized workflows, and deep insights. Optimized for imaging tissue and plant specimens, as well as pathology, these microscopes are designed to accelerate and tailor your workflows.

DM4 B & DM6 B

Read our latest articles about Upright Microscopes

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments.

Ultramicrotome UC Enuity in Practice: Stable 15 nm Sections at ZFE

After using the UCT and UC6 ultramicrotomes, Claudia Mayrhofer calls UC Enuity a leap in stability—so robust that vibrations and temperature shifts don’t spoil sections, even with multiple users. Auto…

Image of glass with primary corundum having numerous inclusions. It was taken with a microscope using polarization contrast.

Ensuring Glass Quality with the Polarization Microscopy Advantage

Glass is one of the oldest materials known. Today, it is used for many applications, e.g., optical instruments, windows, doors, solar panels, containers for food, beverages, and medicine, so strict…

Expert Techniques for Superior Visualization in Cataract Surgery

Join renowned ophthalmic surgeons, Dr. Hussein Almuhtaseb and Mr. Simon Madge, as they share their clinical expertise and real-world surgical strategies during the 2025 Online Cataract Surgery…

Eliminating Electrostatic Interference in Laser Microdissection

Electrostatic charge in laser microdissection (LMD) causes two critical failures: samples stick to charged surfaces and are lost, or samples fly into adjacent wells and cause cross-contamination. We…

History, Developments and Trends of Microscopy in Cancer Research

Cancer is a global disease, with 18 million new cases diagnosed and 10 million cancer-related deaths worldwide in 2020. This burden is set to increase, with a projected increase in cases of ~55% by…

Mouse fibroblasts where F-actin is labelled with FITC (green), tubulin with Cy5 (red), and nuclei with DAPI (blue). Image courtesy of Dr. Günter Giese, Max Planck Institute for Medical Research, Heidelberg, Germany.

Overview of Fluorescent Dyes in terms of Applications and Properties

An introduction to commonly used fluorescent dyes and an overview of their characteristics are given in this article. Fluorescence microscopy is used for the study of specific cellular components with…

Researchers Insights: Microscopy in Cancer Research

Discover how imaging techniques are driving cancer research forward. In this issue, we present comprehensive multimodal studies using microscopy, as well as new directions in intraoperative cancer…

Predictive Service Prevents Downtime in Ghent

At the VIB BioImaging Core in Ghent, Belgium, researchers depend on Leica’s Stellaris 8 confocal microscope to explore the frontiers of biomedical science. When Leica’s RemoteCare system detected a…

Zebrafish heart, DAPI (nuclei, blue), Tropomyosin (cardiomyocytes, red) and GFP (primordial cardiac layer, green). Courtesy of Anna Jazwinska, University of Fribourg, Switzerland.

A Guide to Fluorescence Microscopy

Fluorescence microscopy uses the ability of fluorophores, dyes, or fluorescent proteins to emit light of a specific wavelength after being excited with light of a shorter wavelength. Biomolecules can…

Some 2D measurements, e.g., lengths and areas, made on a PCB sample with a Leica measurement microscope using the Enersight software.

How to Select the Right Measurement Microscope

With a measurement microscope, users can measure the size and dimensions of sample features in both 2D and 3D, something crucial for inspection, QC, failure analysis, and R&D. However, choosing the…

Materials Science and Inspection

Excellent sample preparation and imaging methods are key for inspecting materials and visualizing the fine details with reliability and accuracy. Inverted microscopes enable you to achieve this goal in a more efficient way compared to upright microscopes. They offer you high-quality optics and intelligent automation for optimal workflows.

Life Science Research

Inverted microscopes are often used in life science research for the visualization, measurement, analysis, and documentation of live cell and tissue cultures. Continuous innovative technical advances for inverted microscopes support the ever-changing imaging needs of life science researchers.

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