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Discover new applications by combining confocal and light-sheet microscopy

Digital Light Sheet Microscope STELLARIS DLS

  • Organoids and 3D Cell Culture

    One of the most exciting recent advancements in life science research is the development of 3D cell culture systems, such as organoids, spheroids, or organ-on-a-chip models. A 3D cell culture is an…
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  • Model Organisms in Research

    A model organism is a species used by researchers to study specific biological processes. They have similar genetic characteristics to humans and are commonly used in research areas such as genetics,…
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  • Live Cell Imaging

    Shifting perspective from single microscope components to a full working live cell imaging solution, Leica Microsystems integrates microscope, LAS X imaging software, cameras, and dedicated…
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  • Science Lab Topic: Light Sheet Microscopy

    Effects of Clearing Media on Tissue Transparency and Shrinkage

    This study comprehensively evaluates the effects of different clearing media on tissue transparency and shrinkage by comparing freshly dissected dipteran fly brains with their cleared equivalents.…
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  • Science Lab Topic: Light Sheet Microscopy

    Following Ca²⁺ Changes in Acutely Stimulated Spheroids

    Spheroids are easy and cost-effective 3D cell cultures, useful for fundamental and applied research. They can bridge the gap between 2D and in vivo experiments and can be used for high-throughput…
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  • Science Lab Topic: Light Sheet Microscopy

    Analyzing Structural and Functional Testicular Anatomy

    Fleck, Kenzler et al. have shown that, in mice, muscle-like cells are located within the walls of seminiferous tubules. Using CLARITY and a Leica digital light-sheet (DLS) microscope, Fleck, Kenzler…
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  • Science Lab Topic: Light Sheet Microscopy

    Fish and Chips Sheet into the Light

    The zebrafish larval brain is small and contains about 1 million times less neurons than the human counterpart. The neural circuitry and the general bauplan of the vertebrate brain, however, is…
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  • Science Lab Topic: Light Sheet Microscopy

    Understanding Motor Sequence Generation Across Spatiotemporal Scales

    We have developed a microscopy-based pipeline to characterize a developmentally critical behavior at the pupal stage of development, called the ecdysis sequence. We study brain-wide neuronal activity…
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  • Science Lab Topic: Light Sheet Microscopy

    A Quality Metric for the Systematic Evaluation of Clearing Protocols

    3D multicellular spheroids are of interest for studying tumor behavior and evaluating the response of pharmacologically active agents, because they mimic the in vivo tumor environment better than…
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