James DeRose is a scientific and technical writer for stereo and digital microscopy at Leica Microsystems. He has more than 20 years of experience in scientific and technical writing for book and journal publications. He has co-authored more than 35 scientific and technical publications published in international journals, more than 45 presentations for international scientific conferences and symposiums, and 2 patent applications. He is lead editor for the book "Aluminium Alloy Corrosion of Aircraft Structures: Modelling and Simulation" published in 2012. This book resulted from the EU 6th Framework funded project SICOM. He has managed and contributed to scientific and technical projects focusing on applied R&D and applications development in the fields of interfacial chemistry and physics, thermal and chemical engineering, corrosion and metallography, surface coatings and analysis, materials science, biotechnology, and cellular biology. He has expertise with various types of microscopy and analytical methods. In the past, he worked on applied R&D and applications development projects while at the California Institute of Technology, the Swiss Federal Institute of Technology in Lausanne, as well as the company Cytion (Molecular Devices). James obtained a doctorate in physics with applied research emphasis in surface science, physical chemistry, and biophysics in 1993 from Arizona State University. He has worked at Leica Microsystems since August 2013.
Inspection microscope users can obtain information from this article which helps them choose the optimal microscope illumination or lighting system for inspection of parts or components.
This article explains phase contrast, an optical microscopy technique, which reveals fine details of unstained, transparent specimens that are difficult to see with common brightfield illumination.
How an immersion objective, which has a liquid medium between it and the specimen being observed, helps increase the numerical aperture and microscope resolution is explained in this article.
This article shows how rapidly acquired THUNDER images of Drosophila follicles or egg chambers help distinguish apicobasal proteins when studying epithelial morphogenesis for cancer research.
This article shows how diseases related to scaffold proteins and protein signaling can be studied in zebrafish models efficiently with a THUNDER Imager.
This article explains in simple terms microscope resolution concepts, like the Airy disc, Abbe diffraction limit, Rayleigh criterion, and full width half max (FWHM). It also discusses the history.
This article shows how Interleukin-17 (IL-17) proinflammatory cytokine proteins in human pancreatic islets can be studied efficiently with a THUNDER Imager.
This article explains the FLIM-FRET method which combines resonance energy transfer and fluorescence lifetime imaging to study protein-protein interactions.
This article discusses how the study of neural crest (NC) development in chicken embryos is aided with haze-free imaging using a THUNDER Imager 3D Assay. Proper specification, migration, and…
This article discusses how lens formation and ocular birth defects can be studied with sharp widefield microscopy images which are acquired rapidly. The mouse ocular lens is used as a model to study…
In this article, it is examined how an overall efficient and cost-effective cleanliness analysis workflow can be achieved with a 2-methods-in-1 materials analysis solution, combining optical…
Despite the availability of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance…
The influence of sample preparation and ultraviolet (UV) laser microdissection (UV LMD) on the quality of RNA from murine-brain tissue cryo-sections is described in this article. To obtain good…
This article discusses how the study of mechanisms involved in the generation of healthy oocytes in Drosophila fruit flies can be helped with sharp, haze-free images acquired with a THUNDER Imager…
Choosing the right cleanliness analysis solution is important for optimal quality control. This article discusses the important factors that should be taken into account to find the solution that best…
The fluorescence lifetime is a measure of how long a fluorophore remains on average in its excited state before returning to the ground state by emitting a fluorescence photon.
This article discusses how thick cochlear tissues of chicken embryos can be sharply imaged for studying inner-ear hair cell regeneration. Sensory hair cells perform important functions for hearing and…
