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James DeRose , Ph.D.

James DeRose

James DeRose is a scientific and technical writer for stereo and digital microscopy at Leica Microsystems. He has more than 20 years of experience in scientific and technical writing for book and journal publications. He has co-authored more than 35 scientific and technical publications published in international journals, more than 45 presentations for international scientific conferences and symposiums, and 2 patent applications. He is lead editor for the book "Aluminium Alloy Corrosion of Aircraft Structures: Modelling and Simulation" published in 2012. This book resulted from the EU 6th Framework funded project SICOM. He has managed and contributed to scientific and technical projects focusing on applied R&D and applications development in the fields of interfacial chemistry and physics, thermal and chemical engineering, corrosion and metallography, surface coatings and analysis, materials science, biotechnology, and cellular biology. He has expertise with various types of microscopy and analytical methods. In the past, he worked on applied R&D and applications development projects while at the California Institute of Technology, the Swiss Federal Institute of Technology in Lausanne, as well as the company Cytion (Molecular Devices). James obtained a doctorate in physics with applied research emphasis in surface science, physical chemistry, and biophysics in 1993 from Arizona State University. He has worked at Leica Microsystems since August 2013.

Particles which could be found during cleanliness analysis of parts and components.

Cleanliness of Automotive Components and Parts

This article discusses the ISO 16232 standard and VDA 19 guidelines and briefly summarizes the particle analysis methods. They give important criteria for the cleanliness of automotive parts and…
Multiple particles seen on a filter imaged with a microscope

Improving the Cleanliness Analysis Workflow

For automotive manufacturers and automotive component suppliers, obtaining cleanliness results rapidly, accurately, and reliably over the entire workflow is a significant advantage. Often for this…
Two-color caspase assay with tile scan

Multi-Color Caspase 3/7 Assays with Mica

Caspases are involved in apoptosis and can be utilized to determine if cells are undergoing this programmed cell death pathway in so-called caspase assays. These assays can be run by e.g. flow…
Raw widefield and THUNDER image of a mouse dorsal root ganglion with tdTomato (red) expressed in the sensory neurons.

Fast, High-contrast 3D Imaging of Sensory Neurons

This article discusses how fast, high-contrast 3D imaging of dorsal root ganglion (DRG) tissue with a THUNDER Imager Tissue using large volume computational clearing (LVCC) allows sensory neurons to…
Identification of distinct structures_roundworm_Ascaris_female

Find Relevant Specimen Details from Overviews

Switch from searching image by image to seeing the full overview of samples quickly and identifying the important specimen details instantly with confocal microscopy. Use that knowledge to set up…
Documentation of an automotive clutch friction surface with a digital microscope

Verifying Specifications for Auto Parts and Components

During the development and production of automotive parts and components, whether by suppliers or the auto manufacturer, specifications must be met. This goal is important, because the specifications…
Raw widefield (left) and THUNDER (right) image of Ewing Sarcoma cells (SK-ES-1).

Visualizing the Mitotic Spindle in Cancer Cells

This article demonstrates how this research is aided by visualizing more details of mitotic spindles in Ewing Sarcoma cells using the THUNDER Imager Tissue and Large Volume Computational Clearing…
Electronic component

Top Challenges for Visual Inspection

This article discusses the challenges encountered when performing visual inspection and rework using a microscope. Using the right type of microscope and optical setup is paramount in order to…
Visual inspection of a PCBA with the Ivesta 3 Greenough stereo microscope.

How to Select the Right Solution for Visual Inspection

This article helps users with the decision-making process when selecting a microscope as a solution for routine visual inspection. Important factors that should be considered are described.

Introduction to 21 CFR Part 11 and Related Regulations

This article provides an overview of regulations and guidelines for electronic records (data entry, storage, signatures, and approvals) used in the USA (21 CFR Part 11), EU (GMP Annex 11), and China…

Why is Manual Visual Inspection of Medical Devices so Challenging?

This article discusses how manual visual inspection, which is prevalent in the medical device industry, can lead to inconsistent results. It also addresses the challenges quality managers and…
Dividing fission yeast S. pombe stained with two markers against spindle pole bodies (Pcp1-GFP, green) and cytokinesis ring (Rlc1-mCherry; red).

Studying Cell Division

Cell division is a biological process during which all cellular components must be distributed among the daughter cells. The division process requires firm coordination for success. Microscopy is…

Investigating Synapses in Brain Slices with Enhanced Functional Electron Microscopy

A fundamental question of neuroscience is: what is the relationship between structural and functional properties of synapses? Over the last few decades, electrophysiology has shed light on synaptic…
Topographic analysis of firing pin.

Topographic Analysis of Firing Pin Impressions on Cartridge Cases

The analysis of fired cartridges for primer cup morphology and flattening and firing pin impression (crater) depth using topographic data is discussed in this article. Topographical analysis of the…
Mouse lung sections

Studying Pulmonary Fibrosis

The results shown in this article demonstrate that fibrotic and non-fibrotic regions of collagen present in mouse lung tissue can be distinguished better with polarized light compared to brightfield.…

Keeping Particulate Contamination Under Control in Pharmaceutical Products

This article describes how a 2-methods-in-1 solution combining optical microscopy and laser induced breakdown spectroscopy (LIBS) can be utilized for identification of particulate contaminants in the…

Fast Visual and Chemical Analysis of Contamination and Underlying Layers

Visual and chemical analysis of contamination on materials with a 2-methods-in-1 solution leading to an efficient, more complete analysis workflow is described in this report. A 2-in-1 solution,…

How does an Automated Rating Solution for Steel Inclusions Work?

The rating of non-metallic inclusions (NMIs) to determine steel quality is critical for many industrial applications. For an efficient and cost-effective steel quality evaluation, an automated NMI…
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