Ultramicrotomes & Cryo-Ultramicrotomes
Whether tissue sample, polymer, rubber, metals or nanoparticles, Leica ultramicrotomes provide extremely thin sections and perfect surface quality in a wide range of applications. From materials science to cancer research, our ultramicrotomes are used for many different kinds of research and quality control all over the world.
Thin sections and perfect surface quality!
Contact our team of experts to help you simplify your EM sample preparation.
Users often operate an ultramicrotome for a long period of time. Therefore, fatigue-free operation is a must for both right- and left- handed users. Ergonomic arm rests and generous adjustment options make working with ultramicrotomes from Leica Microsystems more comfortable.
Leica ultramicrotomes guarantee precision and comfort. Thanks to the fully motorized knife stages and a wealth of technical features, even beginners can prepare perfect sections. Make perfect glass knives for perfect ultrathin sections with the Leica EM KMR3 within minutes.
The instruments produce section thicknesses between 10 nm up to 15 µm. Discover the precision mechanics of the Leica EM UC7 ultramicrotome and enjoy highest quality specimen preparation for LM, TEM, SEM, or AFM examination.
Four Steps to Cryo-Section
Make your Ultramicrotome Leica EM UC6 or Leica EM UC7 a Cryoultramicrotome within minutes by mounting the cryochamber Leica EM FC7 and prepare your cryo sections (-15° to -185°C) for TEM, SEM, AFM, and LM.
ultramicrotomy related articles
Read our latest articles about Ultramicrotomy
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments.
Introduction to Ultramicrotomy
Array Tomography for SEM 3D Reconstruction
Cryo-Electron Microscopy of Vitreous Sections (CEMOVIS) of Yeast
Brief Introduction to Specimen Trimming
Ion Beam Milling Systems
When material specimen surfaces are prepared for SEM or incident light microscopy, the specimen usually undergoes multiple processes until the layer or surface to be analyzed is machined with precision. Leica Microsystems’ workflow solutions for solid state technology cover all steps required for demanding high-quality sample preparation.
Sputter Coater & Freeze Fracture Solutions
To obtain high-quality images of samples with scanning (SEM) or transmission electron microscopy (TEM), your samples need to be conductive to avoid charging. If a sample does not have a high enough conductivity, then you can quickly cover it with a conductive layer using the method of sputter coating. Also, a carbon or e-beam evaporator coating can be used. Such coatings protect the sample, allow enhancing of the EM image contrast, or can act as a TEM-grid support film for small scale samples.
Cryo Preparation Systems
High pressure freezing is often the preferred method for preserving aqueous samples in their close-to-native state, as it captures the intricate changes in fine structure or cellular dynamics. Leica Microsystems combines high pressure freezing with light stimulation or electrical stimulation: It enables you to visualize highly dynamic processes or the structural changes of samples at a nanometer resolution and with millisecond precision.
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