Confocal Light Microscope STELLARIS 5 Cryo

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Projection of a confocal z-stack before and after LIGHTNING applied. Sum159 cells, human breast cancer cells kindly provided by Ievgeniia Zagoriy, Mahamid Group, EMBL Heidelberg, Germany. Blue – Hoechst - indicates nuclei, Green – MitoTracker Green – mitochondria, and red – Bodipy - lipid droplets.

New Imaging Tools for Cryo-Light Microscopy

LIGHTNING super-resolution detection concept and TauSense technology facilitate better cryogenic fluorescence imaging for advanced cryo-correlative workflows. The quality of fluorescence microscope…
Correlation of markers in the LM and the FIB image.

How to Target Fluorescent Structures in 3D for Cryo-FIB Milling

This article describes the major steps of the cryo-electron tomography workflow including super-resolution cryo-confocal microscopy. We describe how subcellular structures can be precisely located in…
LNG-non-LNGHeLa cells labeled with light blue –Hoechst, Nuclei

Precise 3D Targeting for EM Imaging - Access What Matters

Find out how the seamless cryo-electron tomography workflow Coral Cryo uses confocal super resolution to target your structure of interest more precisely.

Fields of Application

Cryo-Electron Tomography

Cryo-electron tomography (CryoET) is used to resolve biomolecules within their cellular environment down to an unprecedented resolution below one nanometer.
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