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We work with pancreatic cancer organoids so, whenever we find interesting structures and want to zoom in and have higher resolution, then, with basically one click, we can switch from the epifluorescence to confocal mode.

Dr. Anna Pastucha, Light Microscopy Facility Manager, Center for Functional Protein Assemblies, Technical University of Munich, Germany
 

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No constraints - 4x more data with 100% correlation

The Microhub enables you to simultaneously capture all 4 labels of different structures in a single acquisition for widefield or confocal, without ever moving your sample. This overcomes the spatiotemporal mismatch between labels of moving objects during sequential acquisition. All powered by our patented FluoSync technology, a fast and gentle method for multicolor fluorescence imaging.

No constraints - Select the right modality in real time

Mica unifies transmitted and fluorescence light imaging modalities. You can select from multiple imaging modalities all within one Microhub, including widefield, confocal, THUNDER imaging, LIGHTNING, Z-stacks, time-lapse and more.

This enables you to

  • generate fast overviews with widefield at low magnification
  • gradually zoom in on the regions of interest
  • switch to confocal when and where needed without ever moving the sample to a different system
3D Cell Culture, 7d spheroid formation of U343 cells. tfLC3 EGFP and mRFP + DAPI + WGA Alexa680. Objective: 20x NA 0.70 DRY

No constraints - Achieve physiological-like conditions throughout your experiments

Live cell experiments require the cells to be in optimal shape. Typically, 2D and 3D cells in media require the temperature and the pH (via CO2) in the environment to be controlled. Stable nutrition and ion concentrations require the evaporation to be minimal. Some experiments even demand the O2 to be mimicked closer to physiological levels. Mica can provide the right conditions in the live cell configuration. 

  • Mica is an incubator: the entire encapsulated inner sample space can be climate controlled (temperature, CO2 and humidity regulation) and offers ideal conditions for short and long-term live cell observation.
  • From dark to light: Mica also enables you to enjoy a brightly lit lab—freeing you from the constraints of sitting in a dark room for hours monitoring your experiment.
Formation of 3D spheroids from 1000 stably transfected MDCK MX1-GFP cells per well (left half) and 1000 U2OS cells per well (right half). Time-lapse acquisition over 60 hrs. with 30 minutes interval. Green, GFP. Gray, integrated modulation contrast.

Radically simplified workflows

Intelligent automation and AI-supported analysis enable greater efficiency and a faster track to publication. 

  • Reduce over 60% of process steps through system intelligence
  • Reduce time and effort from sample to insight by simplifying your entire workflow
  • Enable clearer, more confident decision making with optimized charts, including heatmaps and dose‑response curves, for well‑plate assays, with Aivia (included as part of Mica)
Top: Colchicine-treated CHO cells (increasing concentration from left to right) imaged on a polystyrene plastic bottom multi well plate using Mica with a HC PL FLUOTAR L 20x/0.60 motCORR objective. Shown are montages of 1/4 of the FOV per well (D5–F11). Nuclei stained with Hoechst 33342. Bottom: Analysis and heatmap visualization of cell count (blue: low, red: high) (left). Same data shown as a dose-response-curve including quantification of EC50 value (right).
Top: Colchicine-treated CHO cells (increasing concentration from left to right) imaged on a polystyrene plastic bottom multi well plate using Mica with a HC PL FLUOTAR L 20x/0.60 motCORR objective. Shown are montages of 1/4 of the FOV per well (D5–F11). Nuclei stained with Hoechst 33342. Bottom: Analysis and heatmap visualization of cell count (blue: low, red: high) (left). Same data shown as a dose-response-curve including quantification of EC50 value (right).

Popular Configurations

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Mica 20x LWD Objective with Service Installation

Mica 20x LWD Objective with Service Installation

20x long working distance objective for imaging on glass and plastic bottom carriers.

To penetrate deeper into samples using everyday standard plastic-bottom multi well plates, this Long Working Distance (LWD) objective has been optimized for use with Mica.

· No need to sacrifice image quality

· No need for costly glass-bottom alternatives

· Avoid the frustration of switching carriers and re-optimizing your sample preparation protocols

Why is long working distance important?

· Focus deeper, capturing clearer images even with thicker or non-adherent samples such as organoids, spheroids and zebrafish larvae

· Get increased compatibility with high-skirt well plates

· Improve access to outer wells of multi well plates

Please note: This objective requires service installation to ensure correct installation and calibration. A half-day service visit by our expert team is added to ensure optimal performance and system compatibility.

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Microscope Objective HC PL FLUOTAR L 20x/0.60 motCORR

11506438
1

Service Upgrade Installation

9I_HDAY_INST_UPGR
1
Mica Widefield Live Cell Microhub Automated Microscope

Mica Widefield Live Cell Microhub Automated Microscope

Simplify advanced live cell and fluorescence imaging. Get reliable, expert level microscopy results faster with extensive intelligent automation, AI-supported analysis, and an interface designed for ease of use.

Perform long-term live cell experiments up to 4x faster than traditional widefield systems, capturing events that may previously have been missed. Easily get quality images as Mica automatically corrects the focus during experiments. Minimise phototoxicity and maintain optimal cell health with full environmental control.

Ideal for long-term live-cell studies at near physiological conditions.

MICA BENEFITS:

ACCESS FOR ALL: Mica requires minimal technical input and gives consistent results every time, so all lab members can leverage microscopy to make more discoveries.

NO CONSTRAINTS: Get true simultaneous capture of up to four labels without spatiotemporal mismatch – at near-physiological conditions for live cells, or with fixed samples.

RADICALLY SIMPLIFIED WORKFLOWS: Intelligent automation and AI-supported analysis of diverse samples, such as tissues on slides or well plates, enable greater efficiency and a faster track to publication.

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Product includes
Quantity

Keyboard US ;USB Hub

11600220
1

Microscope Objective HC PL APO 63x1,2 W motCORR CS2

11506427
1

Microscope Objective HC PL FLUOTAR L 20x/0.60 motCORR

11506438
1

Mica Core

11525700
1

Okolab Click-In,standard & chamber slide

11525712
1

Mica High Power WS and Analysis Package

11525738
1

HP E32K G5 31.5 UHD IPS"

11533649
1

DSE powered by Aivia

11640663
1

Mica Widefield Live Cell

11889182
1

Service Installation

9I_CM_MICA_C
1

Microscopy Training Basic

9T-CM-APP_BASIC
1
Mica Widefield Microhub Automated Microscope

Mica Widefield Microhub Automated Microscope

Simplify advanced fluorescence imaging through extensive intelligent automation, AI‑supported analysis, and an easy-to-use interface. Now all lab members can get expert microscopy results, regardless of experience.

Ideal for exploration and high-throughput fluorescence imaging of fixed samples.

MICA BENEFITS:

ACCESS FOR ALL: Mica requires minimal technical input and gives consistent results every time, so all lab members can leverage microscopy to make more discoveries.

NO CONSTRAINTS: Get true simultaneous capture of up to four labels for fast acquisitions.

RADICALLY SIMPLIFIED WORKFLOWS: Intelligent automation and AI-supported analysis of diverse samples, such as tissues on slides or well plates, enable greater efficiency and a faster track to publication.

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Product includes
Quantity

Keyboard US ;USB Hub

11600220
1

Microscope Objective HC PL APO 63x1,40 OIL CS2

11506535
1

Microscope Objective HC PL APO 20x/0,75 CS2

11506517
1

Widefield Type F Immersion liquid, ISO 8036

11513859
1

Mica Core

11525700
1

Okolab Click-In,standard & chamber slide

11525712
1

Mica High Power WS and Analysis Package

11525738
1

HP E32K G5 31.5 UHD IPS"

11533649
1

Mica Widefield

11889183
1

Service Installation

9I_CM_MICA_B
1

Microscopy Training Basic

9T-CM-APP_BASIC
1
Mica WideFocal Live Cell Microhub Automated Microscope

Mica WideFocal Live Cell Microhub Automated Microscope

Combine widefield and confocal imaging in an incubating environment and simplify advanced live cell and fluorescence imaging. Extensive intelligent automation, AI-supported analysis, and an easy-to-use interface help you achieve expert microscopy results without all the training.

Perform long-term live cell experiments up to 4x faster than traditional widefield systems, capturing events that may previously have been missed. Easily get quality images as Mica automatically corrects the focus during experiments. Minimise phototoxicity and maintain optimal cell health with full environmental control.

Ideal for long-term and dynamic live cell studies of organoids, spheroids, and 3D cultures.

MICA BENEFITS:

ACCESS FOR ALL: Mica requires minimal technical input and gives consistent results every time, so all lab members can leverage microscopy to make more discoveries.

NO CONSTRAINTS: Visualize in widefield and switch effortlessly to confocal without ever moving your sample. Get true simultaneous capture of up to four labels without spatiotemporal mismatch – at near-physiological conditions for live cells, or with fixed samples.

RADICALLY SIMPLIFIED WORKFLOWS: Intelligent automation and AI-supported analysis of diverse samples, such as tissues on slides or well plates, enable greater efficiency and a faster track to publication.

Loading...
View product details+
Product includes
Quantity

Keyboard US ;USB Hub

11600220
1

Microscope Objective HC PL APO 63x1,2 W motCORR CS2

11506427
1

Microscope Objective HC PL FLUOTAR L 20x/0.60 motCORR

11506438
1

Mica Core

11525700
1

Okolab Click-In,standard & chamber slide

11525712
1

Mica High Power WS and Analysis Package

11525738
1

HP E32K G5 31.5 UHD IPS"

11533649
1

DSE powered by Aivia

11640663
1

Mica WideFocal Live Cell

11889179
1

Service Installation

9I_CM_MICA_E
1

Microscopy Training Basic

9T-CM-APP_BASIC
1
Mica WideFocal Microhub Automated Microscope

Mica WideFocal Microhub Automated Microscope

Combine widefield and confocal imaging in an easy-to-use platform and simplify advanced fluorescence imaging. By streamlining workflows and reducing complexity through intelligent automation, AI-supported analysis, you can get expert microscopy results without all the training.

Ideal for high-resolution imaging of thick or complex samples.

MICA BENEFITS:

ACCESS FOR ALL: Mica requires minimal technical input and gives consistent results every time, so all lab members can leverage microscopy to make more discoveries.

NO CONSTRAINTS : Visualize in widefield and switch effortlessly to confocal without ever moving your sample. Get true simultaneous capture of up to four labels for fast acquisitions.

RADICALLY SIMPLIFIED WORKFLOWS: Intelligent automation and AI-supported analysis of diverse samples, such as tissues on slides or well plates, enable greater efficiency and a faster track to publication.

Loading...
View product details+
Product includes
Quantity

Keyboard US ;USB Hub

11600220
1

Microscope Objective HC PL APO 63x1,40 OIL CS2

11506535
1

Microscope Objective HC PL APO 20x/0,75 CS2

11506517
1

Widefield Type F Immersion liquid, ISO 8036

11513859
1

Mica Core

11525700
1

Okolab Click-In,standard & chamber slide

11525712
1

Mica High Power WS and Analysis Package

11525738
1

HP E32K G5 31.5 UHD IPS"

11533649
1

Mica WideFocal

11889180
1

Service Installation

9I_CM_MICA_D
1

Microscopy Training Basic

9T-CM-APP_BASIC
1

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