Contact & Support
Leica EM ACE600 Coating & Freeze Fracturing Systems Sample Preparation for Electron Microscopy Products Home Leica Leica Microsystems
  • Sample Preparation for Materials Science

    Sample preparation is key for observing the finest textures and details on the sample surface in high resolution. The right workflow and tools for the pre-preparation will lead to an excellently…
    Read article
  • Cryo Electron Tomography

    Leica Microsystems and Thermo Fisher Scientific have collaborated to create a fully integrated cryo-tomography workflow that responds to these research needs: Reveal cellular mechanisms at…
    Read article
  • Automotive & Transportation

    We at Leica want to be your dependendable collaborators, guiding you to optimal imaging solutions for automotive and transportation, so you can stay ahead of the competition. Our smart imaging…
    Read article
  • Cell Culture

    Growing cells under lab conditions is the base for scientists working in fields of cell or developmental biology, cancer research, or any kind of life science and pharma research. Find out how Leica…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Cryo-SEM analysis of UV light stimulated sun screen lotion

    The EM ICE is the only available high-pressure freezer combining light stimulation with fast cryo fixation, a module mostly used for optogenetic approaches in neurobiology studies. However, this…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Visualization of DNA Molecules

    Precise low angle rotary shadowing with heavy metals (like platinum) can be used in transmission electron microscopy (TEM) to observe molecular details of objects previously absorbed on a thin, low…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Carbon Coating for Polymeric Materials

    Application Note fo Leica EM ACE600 - A solid understanding of polymer property-structure relationships is critical to improve and shorten development routes to new products. A direct way to determine…
    Read article
  • Science Lab Topic: EM Sample Preparation

    High-Resolution Carbon Coating: How much Carbon is too much?

    Application Note for Leica EM ACE600 - Carbon support films are routinely used for high resolution TEM. Thickness is one of the main criteria to assess its usefulness for a particular experiment.…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Each Atom Counts: Protect Your Samples Prior to FIB Processing

    Application Note for Leica EM ACE600 - Focused ion beam (FIB) technology has become an indispensable tool for site-specific TEM sample preparation. It allows to extract electron transparent specimens…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Ultra-thin Carbon Support Films for Improved STEM-EELS Analysis of Nanoparticles

    Application Note for Leica EM ACE600 - Recent developments in aberration corrected transmission electron microscopes as well as further improvements in monochromaters and spectrometers have pushed the…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Ways to Reveal More from your Samples: Ultra-Thin Carbon Films

    Application Note for Leica EM ACE600 - Much of the battle involved in obtaining good transmission electron microscopy data is in the specimen preparation itself. Even though some nanomaterials are…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Cryo-SEM Imaging of Latex Paint

    Application Note for Leica EM VCT100, Leica EM ACE600 - A thin layer of latex paint was spread on a clean, scored, silicon chip. The sample was immediately plunge frozen in liquid ethane and…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Improvement of Metallic Thin Films for HR-SEM by Using DC Magnetron Sputter Coater

    Preparation techniques, like several kinds of coating methods play an important role for high resolution scanning electron microscopy (HR-SEM). Nonconductive sample like biological and synthetic…
    Read article
  • Science Lab Topic: EM Sample Preparation

    High Pressure Freezing with Light Stimulation

    Sun screen lotion was carefully filled in the 100 μm incision of a 3 mm copper/gold plated flat carrier and covered with 3 mm sapphire disk. The sun screen lotion sample was then high pressure frozen…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Electron Microscopy Sample Preparation: “The Future is Cold, Dynamic and Hybrid”

    In 2014, the renowned Electron Microscopy for Materials Science (EMAT) research lab at the University Antwerp, Belgium, and Leica Microsystems started a fruitful collaboration to establish a Leica…
    Read article
  • Science Lab Topic: EM Sample Preparation

    How to Clean a Coater

    Coating of samples is required in the field of electron microscopy to enable or improve the imaging of samples. Compared to the traditional coater design, all parts of a Leica EM ACE Coater can be…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Glycerol Spraying/Platinum Low Angle Rotary Shadowing of DNA with the Leica EM ACE600 e-beam

    Glycerol spraying/low angle rotary shadowing (Aebi and Baschong, 2006) is a preparation technique used in biology to visualize structures yielding insufficent contrast with other techniques, due to…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Brief Introduction to Coating Technology for Electron Microscopy

    Coating of samples is required in the field of electron microscopy to enable or improve the imaging of samples. Creating a conductive layer of metal on the sample inhibits charging, reduces thermal…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Carbon Thickness Evaluation in Electron Microscopy

    The coating layers applied and used for electron microscopy imaging are commonly controlled and measured by quartz crystals. These crystals oscillate with a certain frequency (around 6 megahertz when…
    Read article
  • Science Lab Topic: EM Sample Preparation

    Biological Electron Microscopy

    The Electron Microscopy (EM) laboratory in the School of Biological and Biomedical Sciences at Durham University is an integral part of a wider facility spanning a range of advanced imaging tools…
    Read article