Leica Microsystems
Leica Microsystems is a world leader in microscopes and scientific instruments. Founded as a family business in the nineteenth century, the company’s history was marked by unparalleled innovation on its way to becoming a global enterprise.
Its historically close cooperation with the scientific community is the key to Leica Microsystems’ tradition of innovation, which draws on users’ ideas and creates solutions tailored to their requirements. At the global level, Leica Microsystems is organized in three divisions, all of which are among the leaders in their respective fields: Life Science, Industry and Medical.
The company is represented in over 100 countries with 6 manufacturing facilities in 5 countries, sales and service organizations in 20 countries, and an international network of dealers. The company is headquartered in Wetzlar, Germany.
A Guide to C. elegans Research – Working with Nematodes
Efficient microscopy techniques for C. elegans research are outlined in this guide. As a widely used model organism with about 70% gene homology to humans, the nematode Caenorhabditis elegans (also…
How a Breakthrough in Spatial Proteomics Saved Lives
Toxic epidermal necrolysis (TEN) is a rare but devastating reaction to common medications like antibiotics or gout treatments. It begins innocuously, often as a rash, but can escalate rapidly into…
How to Image Axon Regeneration in Deep Muscle Tissue
This study highlights Dr. Aaron Lee’s research on mapping nerve regeneration in muscle grafts post-amputation. Limb loss often leads to reduced quality of life, not only from tissue loss but also due…
Capturing Developmental Dynamics in 3D
This application note showcases how the Viventis Deep dual-view light sheet microscope was successfully used by researchers for exploring high-resolution, long-term imaging of 3D multicellular models…
How to Select the Right Measurement Microscope
With a measurement microscope, users can measure the size and dimensions of sample features in both 2D and 3D, something crucial for inspection, QC, failure analysis, and R&D. However, choosing the…
A Guide to Using Microscopy for Drosophila (Fruit Fly) Research
The fruit fly, typically Drosophila melanogaster, has been used as a model organism for over a century. One reason is that many disease-related genes are shared between Drosophila and humans. It is…
Development and Derisking of CRISPR Therapies for Rare Diseases
This on-demand presentation by Dr. Fyodor Urnov and Dr. Sadik Kassim, originally delivered at ASGCT 2025, focused on a critical challenge in genetic medicine: how to scale CRISPR therapies from…
Microscope Calibration for Measurements: Why and How You Should Do It
Microscope calibration ensures accurate and consistent measurements for inspection, quality control (QC), failure analysis, and research and development (R&D). Calibration steps are described in this…
Integrated Serial Sectioning and Cryo-EM Workflows for 3D Biological Imaging
This on-demand webinar explores how integrated tools can support electron microscopy workflows from sample preparation to image analysis. Experts Andreia Pinto, Adrian Boey, and Hoyin Lai present the…
Revealing Sodium Battery Degradation via Cryo-EM and CryoFIB
Explore how cryogenic electron microscopy and focused ion beam techniques uncover the intrinsic structure of sodium battery interfaces. This webinar presents a new degradation model based on separator…
Multiplexed Imaging Reveals Tumor Immune Landscape in Colon Cancer
Cancer immunotherapy benefits few due to resistance and relapse, and combinatorial therapeutic strategies that target multiple steps of the cancer-immunity cycle may improve outcomes. This study shows…
AI-Powered Hi-Plex Spatial Analysis Tools for Breast Cancer Research
Breast cancer (BC) is the leading cause of cancer-related deaths in women. Investigating the tumor microenvironment (TME) is crucial to elucidate the mechanisms of tumor progression. Systematic…
A Guide to Neuroscience Research
Neuroscience often requires investigating challenging specimens to better understand the nervous system and disorders. Leica microscopes helps neuroscientists obtain insights into neuronal functions.
The “Waffle Method”: High-Pressure Freeze Complex Samples
This article describes the advantages of a special high pressure freezing method, the so-called “Waffle Method”. Learn how the “Waffle Method” uses EM grids as spacers for high-pressure freezing,…
Mastering Polymer Sectioning with Helmut Gnaegi
When it comes to ultramicrotomy, few names carry the weight of Helmut Gnaegi. As co-founder of Diatome, a global leader in diamond knife technology, Helmut has spent decades refining the art and…
A Guide to Zebrafish Research
To obtain optimal results while doing zebrafish research, especially during screening, sorting, handling, and imaging, seeing the fine details and structures is important. They help researchers make…
How to Streamline High-Plex Imaging for 3D Spatial Omics Advances
In this webinar, Dr. Julia Roberti and Dr. Luis Alvarez from Leica Microsystems introduce SpectraPlex, a new functionality integrated into the STELLARIS confocal platform for high-plex 3D spatial…
The Guide to Augmented Reality in Microsurgery
In an era of technological advancement, Augmented Reality (AR) is rapidly transforming the medical field. In surgical microscopy, AR can display fluorescence signals as digital overlays in real-time…
Improving Zebrafish-Embryo Screening with Fast, High-Contrast Imaging
Discover from this article how screening of transgenic zebrafish embryos is boosted with high-speed, high-contrast imaging using the DM6 B microscope, ensuring accurate targeting for developmental…
Transforming Research with Spatial Proteomics Workflows
Spatial Proteomics, Nature Methods 2024 Method of the Year, is driving research advancements in cancer, immunology, and beyond. By combining positional data with high throughput imaging of proteins in…
How Fluorescence Guides Sectioning of Resin-embedded EM Samples
Electron microscopes, including transmission electron microscopes (TEM) and scanning electron microscopes (SEM), are widely utilized to gain detailed structural information about biological samples or…
Coherent Raman Scattering Microscopy Publication List
CRS (Coherent Raman Scattering) microscopy is an umbrella term for label-free methods that image biological structures by exploiting the characteristic, intrinsic vibrational contrast of their…
Selecting the Right Dissecting Microscope
Learn how you can enhance dissection for life-science research and education with a microscope that ensures ergonomic comfort, high-quality optics, and easy access to the specimen.
Get to Insights Faster and Easier with AI Image Analysis Tools
Discover how Aivia helps scientists streamline image analysis with fast setup, accurate AI detection, and easy batch processing.
Unlocking the Secrets of Organoid Models in Biomedical Research
Get ready to delve deeper into the world of organoids and 3D models, which are essential tools for advancing our understanding of human health. Navigating these complex structures and obtaining clear…
A Guide to Polarized Light Microscopy
Polarized light microscopy (POL) enhances contrast in birefringent materials and is used in geology, biology, and materials science to study minerals, crystals, fibers, and plant cell walls.
Factors to Consider when Selecting Clinical Microscopes
What matters if you would like to purchase a clinical microscope? Learn how to arrive at the best buying decision from our Science Lab Article.
Clinical Microscopy: Considerations on Camera Selection
The need for images in pathology laboratories has significantly increased over the past few years, be it in histopathology, cytology, hematology, clinical microbiology, or other applications. They…
How to Save Time and Samples by Automated Ultramicrotomy
This article describes how 3D micro-CT data of a resin-embedded electron microscopy sample can be used to trim the specimen down to a defined target plane prior to sectioning. The interactive and…
Essential Guide to Ultramicrotomy
When studying samples, to visualize their fine structure with nanometer scale resolution, most often electron microscopy is used. There are 2 types: scanning electron microscopy (SEM) which images the…
