I. J. Marques, A. Ernst, P. Arora, A. Vianin, T. Hetke, A. Sanz-Morejón, U. Naumann, A. Odriozola ,X. Langa, L. Andrés-Delgado, B. Zuber, C. Torroja, M. Osterwalder, F. C. Simões, C. Englert & N. Mercader:
Wt1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium
Development (2022) 149 (6): dev200375.
Using the zebrafish as an in vivo model for development, this study shows that sustained Wt1 ortholog expression in cardiomyocytes impaired their maturation including sarcomere assembly, ultimately affecting cardiac morphology and function. Indeed, a subset of wt1a- or wt1b-expressing cardiomyocytes changed their cell adhesion properties, delaminated from the myocardial epithelium and assumed an epicardium-like phenotype. From this study, it was concluded that Wt1 plays a yet undescribed role for cardiomyocyte differentiation by repressing chromatin opening at specific genomic loci and that sustained ectopic expression of wt1a or wt1b in cardiomyocytes can lead to their transformation into epicardial cells.
Related Articles
-
Coherent Raman Scattering Microscopy Publication List
CRS (Coherent Raman Scattering) microscopy is an umbrella term for label-free methods that image…
Sep 11, 2023Read article -
What is the Patch-Clamp Technique?
This article gives an introduction to the patch-clamp technique and how it is used to study the…
May 04, 2023Read article -
How to do a Proper Cell Culture Quick Check
In order to successfully work with mammalian cell lines, they must be grown under controlled…
Feb 06, 2023Read article
Related Pages
-
Confocal Microscopes
Our confocal microscopes for top-class biomedical research provide imaging precision for subcellular…
Visit related page -
Live Cell Imaging
Shifting perspective from single microscope components to a full working live cell imaging solution,…
Visit related page
