Science Lab

Bem-vindo ao portal de conhecimento da Leica Microsystems. Você encontrará pesquisas científicas e material didático sobre o tema microscopia. O portal oferece suporte a iniciantes, profissionais experientes e cientistas em seus trabalhos e experimentos diários. Explore tutoriais interativos e notas de aplicação, descubra os fundamentos da microscopia, bem como as tecnologias de ponta. Faça parte da comunidade do Science Lab e compartilhe sua experiência.

Fixed patient-derived neuroendocrine tumor organoids labeled with DAPI (cyan) and phalloidin (magenta), imaged using Viventis SCAPE; scale bar 50μm. Courtesy of Marina Cuenca and Heleen Jungen (Dayton lab), EMBL Barcelona.

What’s the Best Organoid Imaging Approach for Early Drug Discovery?

Organoids and other complex in vitro models (CIVMs) are becoming increasingly important in early drug discovery and translational research, driven by the need for more predictive, human-relevant data…

Large field of view (FOV) 2D slices of a 1 mm diameter midbrain neural organoid stained with DAPI (blue, nuclear stain), β-tubulin (green, neuronal stain), and GFAP (red, astrocyte stain). Acquired on THUNDER Imager Cell with 10x magnification. Left: Raw widefield image, Right: THUNDER cleared image. Scale bar 400 μm. Sample courtesy of Dr Tanya Singh, University of Oxford, UK.

Fast, High-Contrast Widefield Imaging of Optically Challenging Samples

Live‑cell imaging of large, complex biological samples often requires large fields of view, sub-cellular resolution, high-sensitivity, and fast acquisition – all while maintaining low illumination…

Shown is the DMi8 inverted microscope which is used for life-science research.

Factors to Consider When Selecting a Research Microscope

An optical microscope is often one of the central devices in a life-science research lab. It can be used for various applications which shed light on many scientific questions. Thereby the…

Image of roundworm C. elegans acquired with a M205 FA fluorescence automated stereo microscope in combination with Rottermann contrast. Areas labelled with mCherry are seen as reddish purple.

A Guide to C. elegans Research – Working with Nematodes

Efficient microscopy techniques for C. elegans research are outlined in this guide. As a widely used model organism with about 70% gene homology to humans, the nematode Caenorhabditis elegans (also…

Zebrafish-embryo image captured using a THUNDER Imager Tissue and live instant computational clearing.

Improving Zebrafish-Embryo Screening with Fast, High-Contrast Imaging

Discover from this article how screening of transgenic zebrafish embryos is boosted with high-speed, high-contrast imaging using the DM6 B microscope, ensuring accurate targeting for developmental…

Image: Human stem cell-derived mid brain organoids. Courtesy of Dr Tanya Singh, University of Oxford.

Unlocking the Secrets of Organoid Models in Biomedical Research

Get ready to delve deeper into the world of organoids and 3D models, which are essential tools for advancing our understanding of human health. Navigating these complex structures and obtaining clear…

Transfection using the Uncommon Bio reprogramming system. Image acquired using the THUNDER Imager 3D Cell Culture with THUNDER Large Volume Computational Clearing (LVCC) applied. Image courtesy of Samuel East, Uncommon Bio.

Designing the Future with Novel and Scalable Stem Cell Culture

Visionary biotech start-up Uncommon Bio is tackling one of the world’s biggest health challenges: food sustainability. In this webinar, Stem Cell Scientist Samuel East shows how they make stem cell…

Stripe assay performed on a THUNDER Imager Cell. Courtesy of Maria Carrasquero Ordaz, University of Oxford.

Revealing Neuronal Migration’s Molecular Secrets

Different approaches can be used to investigate neuronal migration to their niche in the developing brain. In this webinar, experts from The University of Oxford present the microscopy tools and…

Dapi – Nucleus, GFP – Plasma Membrane, Thickness 100µm, 63x objektive, 469 Z planes, 2 channels, THUNDER Imager 3D Cell Culture. Courtesy M.Sc. Dana Krauß, Medical University of Vienna (Austria).

How Efficient is your 3D Organoid Imaging and Analysis Workflow?

Organoid models have transformed life science research but optimizing image analysis protocols remains a key challenge. This webinar explores a streamlined workflow for organoid research, starting…