Science Lab

Benvenuti nel portale delle conoscenze di Leica Microsystems. Troverete materiale didattico e di ricerca scientifica sul tema della microscopia. Il portale supporta i principianti, i professionisti esperti e gli scienziati nel loro lavoro quotidiano e negli esperimenti. Esplorate i tutorial interattivi e le note applicative, scoprite le basi della microscopia e le tecnologie di punta. Entrate a far parte della comunità di Science Lab e condividete la vostra esperienza.

Leitz Laborlux: Tartaric acids, polarization contrast

The Polarization Microscopy Principle

Polarization microscopy is routinely used in the material and earth sciences to identify materials and minerals on the basis of their characteristic refractive properties and colors. In biology,…

Stripe assay performed on a THUNDER Imager Cell. Courtesy of Maria Carrasquero Ordaz, University of Oxford.

Revealing Neuronal Migration’s Molecular Secrets

Different approaches can be used to investigate neuronal migration to their niche in the developing brain. In this webinar, experts from The University of Oxford present the microscopy tools and…

Cell DIVE image of stromal remodeling around B cell follicles of follicular lymphoma patients. Stromal cells labeled with antibodies against desmin (red), SPARC (orange), vimentin (blue), and a-sma (yellow). Extracellular matrix labeled with antibody against lumican (cyan). B cells labeled with antibody against CD20 (green). Image credit: Dr. Andrea Radtke, Center for Advanced Tissue Imaging, NIAID, NIH

Empowering Spatial Biology with Open Multiplexing and Cell DIVE

Spatial biology and multiplexed imaging workflows have become important in immuno-oncology research. Many researchers struggle with study efficiency, even with effective tools and protocols. Here, we…

How did Laser Microdissection enable Pioneering Neuroscience Research?

Dr. Marta Paterlini, a Senior Scientist at the Karolinska Institute, shares her experience of using laser microdissection (LMD) in groundbreaking research into adult human neurogenesis and offers…

The role of extracellular signalling mechanisms in the correct development of the human brain

How do Cells Talk to Each Other During Neurodevelopment?

Professor Silvia Capello presents her group’s research on cellular crosstalk in neurodevelopmental disorders, using models such as cerebral organoids and assembloids.

40x magnification of organoids cluster taken on Mateo TL.Cell type: esophageal squamous carcinoma; scale bar 15µm. Courtesy of bioGenous, China.

Overcoming Observational Challenges in Organoid 3D Cell Culture

Learn how to overcome challenges in observing organoid growth. Read this article and discover new solutions for real-time monitoring which do not disturb the 3D structure of the organoids over time.

Microscope equipped with a K7 color CMOS camera for life-science and industry imaging applications.

Technical Terms for Digital Microscope Cameras and Image Analysis

Learn more about the basic principles behind digital microscope camera technologies, how digital cameras work, and take advantage of a reference list of technical terms from this article.

Adult human Alzheimer’s brain demonstrating a panel of 15 markers.

The Shape of the Brain: Spatial Biology of Alzheimer’s Disease

Uncover cell identity and brain structure in Alzheimer's disease with Cell DIVE multiplexed imaging, demonstrating how spatial biology can lead to advances in therapy development for…

Image of immunofluorescently labelled cells where mitochondria are indicated with red, nuclei with blue, and actin with green.

Studying Virus Replication with Fluorescence Microscopy

The results from research on SARS-CoV-2 virus replication kinetics, adaption capabilities, and cytopathology in Vero E6 cells, done with the help of fluorescence microscopy, are described in this…