What’s the Best Organoid Imaging Approach for Early Drug Discovery?
Organoids and other complex in vitro models (CIVMs) are becoming increasingly important in early drug discovery and translational research, driven by the need for more predictive, human-relevant data…
Fast, High-Contrast Widefield Imaging of Optically Challenging Samples
Live‑cell imaging of large, complex biological samples often requires large fields of view, sub-cellular resolution, high-sensitivity, and fast acquisition – all while maintaining low illumination…
A Guide to Fluorescence Microscopy
Fluorescence microscopy uses the ability of fluorophores, dyes, or fluorescent proteins to emit light of a specific wavelength after being excited with light of a shorter wavelength. Biomolecules can…
Guide to Live-Cell Imaging
For a wide range of applications in various research fields of life science, live-cell imaging is an indispensable tool for visualizing cells in a state as close to in vivo, i.e. living and active, as…
Factors to Consider When Selecting a Research Microscope
An optical microscope is often one of the central devices in a life-science research lab. It can be used for various applications which shed light on many scientific questions. Thereby the…
Infinity Optical Systems - From “Infinity Optics” to the Infinity Port
“Infinity Optics” is the concept of a light path with parallel rays between the objective and tube lens of a microscope [1]. Placing flat optical components into this “infinity space” which do not…
How a Breakthrough in Spatial Proteomics Saved Lives
Toxic epidermal necrolysis (TEN) is a rare but devastating reaction to common medications like antibiotics or gout treatments. It begins innocuously, often as a rash, but can escalate rapidly into…
A Novel Laser-Based Method for Studying Optic Nerve Regeneration
Optic nerve regeneration is a major challenge in neurobiology due to the limited self-repair capacity of the mammalian central nervous system (CNS) and the inconsistency of traditional injury models.…
How to Image Axon Regeneration in Deep Muscle Tissue
This study highlights Dr. Aaron Lee’s research on mapping nerve regeneration in muscle grafts post-amputation. Limb loss often leads to reduced quality of life, not only from tissue loss but also due…
