Science Lab

Benvenuti nel portale delle conoscenze di Leica Microsystems. Troverete materiale didattico e di ricerca scientifica sul tema della microscopia. Il portale supporta i principianti, i professionisti esperti e gli scienziati nel loro lavoro quotidiano e negli esperimenti. Esplorate i tutorial interattivi e le note applicative, scoprite le basi della microscopia e le tecnologie di punta. Entrate a far parte della comunità di Science Lab e condividete la vostra esperienza.

Light sheet microscopy tilescan of zebrafish.

Using U-Shaped Glass Capillaries for Sample Mounting

The DLS microscope system from Leica Microsystems is an innovative concept which integrates the Light Sheet Microscopy technology into the confocal platform. Due to its unique optical architecture,…

Multiphoton microscopy of an unstained mouse skin section acquired using the 4Tune detector.

Mission Impossible Accomplished: Tunable Colors for Non-descanning Detection

Leica Microsystems’ 4Tune detector, the key component of the SP8 DIVE Deep In Vivo Explorer, provides spectrally tunable image recording with non-descanning detection. An innovative solution for…

Comparison when observing a rodent model organism with a Greenough versus CMO (common main objective) stereo microscope for a task like surgery.

Rodent and Small-Animal Surgery

Learn how you can perform rodent (mouse, rat, hamster) and small-animal surgery efficiently with a microscope for developmental biology and medical research applications by reading this article.

Transgenic zebrafish larva where fluorescent proteins label the heart muscle blue, blood and blood vessels red, and all circulatory system cells green. Image recorded with a M205 FA microscope.

Imaging and Analyzing Zebrafish, Medaka, and Xenopus

Discover how to image and analyze zebrafish, medaka, and Xenopus frog model organisms efficiently with a microscope for developmental biology applications from this article.

Fluorescence stereo microscope image of anesthetized Mediterranean fruit flies recorded with a M205 stereo microscope.

Investigating Fruit Flies (Drosophila melanogaster)

Learn how to image and investigate Drosophila fruit fly model organisms efficiently with a microscope for developmental biology applications from this article.

Studying Caenorhabditis elegans (C. elegans)

Find out how you can image and study C. elegans roundworm model organisms efficiently with a microscope for developmental biology applications from this article.

Epoxy Resin Embedding of Animal and Human Tissues for Pathological Diagnosis and Research

Application Note for Leica EM AMW - The tissues were fixed in the modified Karnovsky fixative generally by immersion overnight (at minimum 4h at room temperature). Then pieces of approx. 1mm3 were cut…

Brief Introduction to Freeze Substitution

Freeze-substitution is a process of dehydration, performed at temperatures low enough to avoid the formation of ice crystals and to circumvent the damaging effects observed after ambient-temperature…

Structural details of the C. elegans, head in cross-section. Courtesy of Müller-Reichert T, MPI-CBG, Dresden, Germany, and McDonald K, University of California, Berkeley, USA.

Brief Introduction to High-Pressure Freezing

Water is the most abundant cellular constituent and therefore important for preserving cellular ultra-structure. Currently the only way to fix cellular constituents without introducing significant…