Leica Microsystems
Leica Microsystems is a world leader in microscopes and scientific instruments. Founded as a family business in the nineteenth century, the company’s history was marked by unparalleled innovation on its way to becoming a global enterprise.
Its historically close cooperation with the scientific community is the key to Leica Microsystems’ tradition of innovation, which draws on users’ ideas and creates solutions tailored to their requirements. At the global level, Leica Microsystems is organized in three divisions, all of which are among the leaders in their respective fields: Life Science, Industry and Medical.
The company is represented in over 100 countries with 6 manufacturing facilities in 5 countries, sales and service organizations in 20 countries, and an international network of dealers. The company is headquartered in Wetzlar, Germany.
Multicolor Microscopy: The Importance of Multiplexing
The term multiplexing refers to the use of multiple fluorescent dyes to examine various elements within a sample. Multiplexing allows related components and processes to be observed in parallel,…
Considerations for Multiplex Live Cell Imaging
Simultaneous multicolor imaging for successful experiments: Live-cell imaging experiments are key to understand dynamic processes. They allow us to visually record cells in their living state, without…
A New Method for Convenient and Efficient Multicolor Imaging
The technique combining hyperspectral unmixing and phasor analysis was developed to simplify the process of getting images from a sample labeled with multiple fluorophores. This aggregate method…
Simplifying the Cancer Biology Image Analysis Workflow
As cancer biology data sets grow, so do the challenges in microscopy image analysis. Aivia experts cover how to overcome these challenges with AI.
Examining Critical Developmental Events in High-Definition
Extended live cell imaging of embryo development requires a delicate balance between light exposure, temporal resolution and spatial resolution to maintain cells’ viability. Compromises between the…
Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS
Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…
Top Challenges for Visual Inspection
This article discusses the challenges encountered when performing visual inspection and rework using a microscope. Using the right type of microscope and optical setup is paramount in order to…
How to Boost your Microelectronic Component Inspection Performance
Do you need to see more when inspecting silicon wafers or MEMS? Would you like to get sharp and detailed sample images which are similar to those from electron microscopes?
Watch this free webinar…
How Industrial Applications Benefit from Fluorescence Microscopy
Watch this free webinar to know more about what you can do with fluorescence microscopy for industrial applications. We will cover a wide range of investigations where fluorescence contrast offers new…
How to Select a Microscope for Cataract Surgery
What to consider in the selection of an ophthalmic microscope for cataract procedures. Bearing these aspects in mind will equip surgeons well for talks with manufacturer representatives. Many…
Intravital Microscopy of Cancer
Join our guest speaker Prof Dr Jacco van Rheenen, as he presents his work on the identity, behavior and fate of cells that drive the initiation and progression of cancer.
Accelerating Neuron Image Analysis with Automation
The ability to examine complex neural processes relies on the accurate reconstruction of neuronal networks at scale. Most data extraction methods in neuroscience research are time-consuming and…
Tracking Single Cells Using Deep Learning
AI-based solutions continue to gain ground in the field of microscopy. From automated object classification to virtual staining, machine and deep learning technologies are powering scientific…
Learning the Cellular Architecture from its Optical Properties
In the last 3 years, microscopists have started to use "AI based" solutions for a wide range of applications, including image acquisition optimization (smart microscopy), object classification, image…
How to Select the Right Solution for Visual Inspection
This article helps users with the decision-making process when selecting a microscope as a solution for routine visual inspection. Important factors that should be considered are described.
How to Use a Digital Microscope to Streamline Inspection Processes
Watch this webinar for inspiration and expert advice on how to make quality control simpler, quicker, and easier. Learn how to perform comprehensive visual inspection, including comparison,…
Artificial Intelligence and Confocal Microscopy – What You Need to Know
This list of frequently asked questions provides “hands-on” answers and is a supplement to the introductory article about Dynamic Signal Enhancement powered by Aivia "How Artificial Intelligence…
How Artificial Intelligence Enhances Confocal Imaging
In this article, we show how artificial intelligence (AI) can enhance your imaging experiments. Namely, how Dynamic Signal Enhancement powered by Aivia improves image quality while capturing the…
Designing your Research Study with Multiplexed IF Imaging
Multiplexed tissue analysis is a powerful technique that allows comparisons of cell-type locations and cell-type interactions within a single fixed tissue sample. It is common for researchers to ask…
Cross Section Ion Beam Milling of Battery Components
Sample Preparation of Lithium battery systems requires high quality surface preparation to evaluate their internal structure and morphology. Due to the brittle materials involved, preparing pristine…
How to Successfully Perform Live-Cell CLEM
The Leica Nano workflow provides a streamlined live-cell CLEM solution for getting insight bout structural changes of cellular components over time. Besides the technical handling described in the…
How to Successfully Implement Coral Life
The live-cell CLEM workflow allows you to capture dynamic information related to a relevant biological process as it happens and put these observations into their ultrastructural context. The Leica…
Advancing Cellular Ultrastructure Research
Freeze-fracture and freeze-etching are useful tools for studying flexible membrane-associated structures such as tight junctions or the enteric glycocalyx. Freeze-fracture and etching are two…
Be Confident in your Results with Cell DIVE Validated Antibodies
The Cell DIVE System includes a carefully curated list of hundreds of commercially available antibodies validated to offer optimal specificity and sensitivity in multiplexed imaging. That validation…
Optimal Visualization in Brain Surgery
This case study “Treatment of the Galassi type III arachnoid cyst with the M530 OHX surgical microscope from Leica Microsystems” documents the procedure step by step and shows the visualization…
Benefits of Combining STED and Lifetime
In this interview, Professor Alberto Diaspro talks about the advantages of the White Light Laser and the TauSTED capabilities of STELLARIS 8 STED. He speaks about his experience with the confocal…
Spectroscopic Evaluation of Red Blood Cells
Hemoglobinopathies are a major healthcare problem. This study presents a possible diagnostic tool for thalassemia which is based on confocal spectroscopy. This approach exploits spectral detection and…
How to use a Surgical Microscope as an Operating Room Nurse
Surgical microscopes play an essential role in the modern microsurgery procedures. It provides the surgeon, assistant and operating room staff with a magnified and illuminated high-quality image of…
How to Improve Live Cell Imaging with Coral Life
For live-cell CLEM applications, light microscopy imaging is a critical step for identifying the right cell in the right state at the right time. In this article, Leica experts share their insights on…
The Cryo-CLEM Journey
This article describes the Cryo-CLEM technology and the benefits it can provide for scientists. Additionally, some scientific publications are highlighted.
Recent developments in cryo electron…
