Science Lab

Bem-vindo ao portal de conhecimento da Leica Microsystems. Você encontrará pesquisas científicas e material didático sobre o tema microscopia. O portal oferece suporte a iniciantes, profissionais experientes e cientistas em seus trabalhos e experimentos diários. Explore tutoriais interativos e notas de aplicação, descubra os fundamentos da microscopia, bem como as tecnologias de ponta. Faça parte da comunidade do Science Lab e compartilhe sua experiência.

Image of burrs (red arrows) at the edge of a battery electrode acquired with a DVM6 digital microscope.

Burr Detection During Battery Manufacturing

See how optical microscopy can be used for burr detection on battery electrodes and determination of damage potential to achieve rapid and reliable quality control during battery manufacturing.

Ultramicrotomy eBook: Targeting, Trimming & Alignment

Ultramicrotomy is evolving rapidly, and today’s microscopes demand high‑quality sections, precise targeting, and reproducible workflows. This eBook brings together expert application notes, automated…

Surgical incision in minimally invasive spine surgery (MISS) case. Image courtesy of Dr. A. Alfieri, Chief Physician & Head of Clinic of Neurosurgery & Spinal Surgery, Cantonal Hospital Winterthur, Switzerland.

Flexibility and Efficiency in Minimally Invasive Spine Surgery

According to Prof. Alex Alfieri, Chief Physician and Head of clinic for Neurosurgery and Spinal surgery at the Cantonal Hospital Winterthur, Minimally invasive spine surgery (MISS) is transforming…

Foraminifera (Ammonia confertitesta) labeled with membrane-permeable calcein, high-pressure frozen in salt water using EM ICE. The sample was cryo-planed and targeted with the M205 on the Cryo-Fluo Enuity, then transferred under cryo conditions to the Cryo-Stellaris for widefield and confocal imaging, revealing details of the staining pattern. Image courtesy: David Evans, University of Southampton.

High-Pressure Freezing for Organoids: Cryo CLEM & FIB Lift Out

Master cryo EM workflow steps for challenging 3D samples: when to choose HPF vs. plunge freezing, reproducible blotting/ice control, contamination aware transfers, Cryo CLEM 3D targeting in organoids,…

Virally labeled neurons (red) and astrocytes (green) in a cortical spheroid derived from human induced pluripotent stem cells. THUNDER Model Organism Imager with a 2x, 0.15 NA objective at 3.4x zoom was used to produce this 425 µm Z-stack (26 positions) which is presented here as an Extended Depth of Field (EDoF) projection. Images courtesy of Dr. F. Birey, Dr. S. Pasca laboratory, Palo Alto, CA.

Guide to Live-Cell Imaging

For a wide range of applications in various research fields of life science, live-cell imaging is an indispensable tool for visualizing cells in a state as close to in vivo, i.e. living and active, as…

A Larger 3D Area in Focus for Neurosurgical and Ophthalmic Microscopes

Neurosurgeons and ophthalmologists deal with delicate structures, deep or narrow cavities and tiny structures with vitally important functions. Seeing a clear, large 3D area of the surgical field in…

Shown is the DMi8 inverted microscope which is used for life-science research.

Factors to Consider When Selecting a Research Microscope

An optical microscope is often one of the central devices in a life-science research lab. It can be used for various applications which shed light on many scientific questions. Thereby the…

Electron microscope (EM) image of a cross section of C. elegans (roundworm). Courtesy of T. Müller-Reichert, MPI-CBG, Dresden, Germany and K. McDonald, University of California, Berkeley, USA.

Brief Introduction to High-Pressure Freezing for Cryo-Fixation

Preparation of biological specimens for electron microscopy (EM) often requires cryo-fixation which does not introduce significant structural alterations of cellular constituents. A common method used…

Advanced Visualization in Head and Neck Reconstructive Surgery

PRS surgeons and maxillofacial specialists face unique challenges in reconstructive procedures, particularly when operating in deep, narrow cavities and working with delicate tissues. Achieving…

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