Industrial Microscopy

Industrial Microscopy

Industrial Microscopy

Dive deep into detailed articles and webinars focusing on efficient inspection, optimized workflows, and ergonomic comfort in industrial and pathological contexts. Topics covered include quality control, materials analysis, microscopy in pathology, among many others. This is the place where you get valuable insights into using cutting-edge technologies for improving precision and efficiency in manufacturing processes as well as accurate pathological diagnosis and research.

A Guide to Neuroscience Research

Are you working towards a better understanding of neurodegenerative diseases or studying the function of the nervous system? See how you can make breakthroughs with imaging solutions from Leica…
Cell DIVE multiplexed image of FFPE tissue section from syngeneic murine cancer model, 4T1.

Mapping Tumor Immune Landscape with AI-Powered Spatial Proteomics

Spatial mapping of untreated tumors provides an overview of the tumor immune architecture, useful for understanding therapeutic responses. Immunocompetent murine models are essential for identifying…

A Practical Guide to Virology Research

Leica solutions for imaging and sample preparation help you with the investigation of viral entry and fusion, genome integration, viral replication, assembly, and virus budding.

A Guide to Cryo-Electron Tomography

Cryo-electron tomography (CryoET) is used to resolve biomolecules within their cellular environment down to an unprecedented resolution below one nanometer.

A Guide to Zebrafish Research

For the best result during screening, sorting, manipulation, and imaging you need to see details and structures to make the right decisions for your next steps in research. Known for outstanding…
Block-face created by automatic trimming under fluorescence. Mammalian cells of interest, stained with CellTrackerTM Green are visualized within the block-face using the UC Enuity equipped with the stereo microscope M205 FA. In the background a carbon finder grid in black is visible. All samples in the article are created by Felix Gaedke, PhD, CECAD, Cologne, Germany.

How to Automatically Obtain Fluorescent Cells of Interest in a Block-face

Block-face created by automatic trimming under fluorescence. Mammalian cells of interest, stained with CellTrackerTM Green are visualized within the block-face using the UC Enuity equipped with the…
Automated Laser Microdissection for Proteome Analysis

Deep Visual Proteomics Provides Precise Spatial Proteomic Information

Despite the availability of imaging methods and mass spectroscopy for spatial proteomics, a key challenge that remains is correlating images with single-cell resolution to protein-abundance…
Developing embryos of different species at different stages during the elongation of their posterior body axis, from left to right in developmental time. The labelled regions in red depict a region of undifferentiated cells called the tailbud, with the corresponding region generated from that tissue shaded in grey. Upper row: lamprey; middle row: catshark; bottom row, zebrafish. This figure has been adapted from the following publication: Steventon, B., Duarte, F., Lagadec, R., Mazan, S., Nicolas, J.-F., & Hirsinger, E. (2016). Species tailoured contribution of volumetric growth and tissue convergence to posterior body elongation in vertebrates. Development, 2016. 143(10):1732-41

How to Study Gene Regulatory Networks in Embryonic Development

Join Dr. Andrea Boni by attending this on-demand webinar to explore how light-sheet microscopy revolutionizes developmental biology. This advanced imaging technique allows for high-speed, volumetric…
Multiplexed Cell DIVE imaging of Adult Human Alzheimer’s brain tissue section demonstrating expression of markers specific to astrocytes (GFAP, S100B), microglia (TMEM119, IBA1), AD-associated markers (p-Tau217, β-amyloid) and immune cells such as CD11b+, CD163+, CD4+, and HLA-DRA+, clustered around the β-amyloid plaques.

Spatial Analysis of Neuroimmune Interactions in Alzheimer’s Disease

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by neurofibrillary tangles, β-amyloid plaques, and neuroinflammation. These dysfunctions trigger or are exacerbated by…
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