Science Lab

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Controlling the TIRF Penetration Depth is Mandatory for Reproducible Results

The main feature of total internal reflection fluorescence (TIRF) microscopy is the employment of an evanescent wave for the excitation of fluorophores instead of using direct light. A property of the…

Primary leaves of cowpea (Vigna unguiculata "California Blackeye") inoculated with cowpea mosaic virus (CPMV) containing the GFP-gene inserted between the movement protein (MP) and the capsid proteins (CPs) in the viral RNA 2

Introduction to Live-Cell Imaging

The understanding of complex and fast cellular dynamics is an important step to get insight into biological processes. Therefore, today’s life science research more and more demands studying…

Snapshot from a time lapse of a calcium imaging experiment using the ratiometric calcium indicator Fura-2.

Ratiometric Imaging

Many fundamental functions of a cell strongly depend on delicate, but nevertheless dynamic balances of ions (e.g. calcium, magnesium), voltage potentials and pH between the cell’s cytosol and the…

Section taste buds rabbit, differential interference contrast microscope

Optical Contrast Methods

Optical contrast methods give the potential to easily examine living and colorless specimens. Different microscopic techniques aim to change phase shifts caused by the interaction of light with the…

New Standard in Electrophysiology and Deep Tissue Imaging

The function of nerve and muscle cells relies on ionic currents flowing through ion channels. These ion channels play a major role in cell physiology. One way to investigate ion channels is to use…