Science Lab

Science Lab

Science Lab

Bienvenido al portal de conocimiento de Leica Microsystems. Aquí encontrará investigación científica y material didáctico sobre el tema de la microscopía. El portal ayuda a principiantes, profesionales experimentados y científicos por igual en su trabajo diario y en sus experimentos. Explore tutoriales interactivos y notas de aplicación, descubra los fundamentos de la microscopía, así como las tecnologías de gama alta. Forme parte de la comunidad Science Lab y comparta sus conocimientos.
Cell DIVE multiplexed image of FFPE tissue section from human invasive ductal carcinoma (IDC)

AI-Powered Hi-Plex Spatial Analysis Tools for Breast Cancer Research

Breast cancer (BC) is the leading cause of cancer-related deaths in women. Investigating the tumor microenvironment (TME) is crucial to elucidate the mechanisms of tumor progression. Systematic…
67-hour, multi-position time-lapse of mouse intestinal organoids expressing the cell cycle reporter FUCCI2 (hGem-mVenus and hCdt1-mCherry).

Focus on Long-Term Imaging in 3D with Light Sheet Microscopy

Long-term 3D imaging reveals how complex multicellular systems grow and develop and how cells move and interact over time, unlocking critical insights into development, disease, and regeneration.…
Aneurysm shown with GLOW800 AR fluorescence application. Image courtesy of Prof. Jacques Guyotat, Hôpital Neurologique Pierre Wertheimer, Lyon

How AR Fluorescence Imaging Supports Neurovascular Surgery

In this article, we explain how fluorescence imaging works in vascular neurosurgery and explain the benefits of the GLOW800 Augmented Reality fluorescence application.
TEM micrographs of polymer sections. Left: Poly(styrene)-b-poly(isoprene). Right: Poly(styrene)-b-poly(methyl methacrylate).

Ultramicrotome Sectioning of Polymers for TEM Analysis

We demonstrate the capabilities of the UC Enuity ultramicrotome from Leica Microsystems for preparing ultrathin sections of polymer samples under both ambient and cryogenic conditions. By presenting…
Radially grown sugar crystals which have been imaged with a Leica microscope using circular polarized light.

Polarizing Microscope Image Gallery

How polarization microscope images can be used for analysis is shown in this gallery. Polarized light microscopy (also known as polarizing microscopy) is an important method for different fields and…
Artificial Intelligence (AI) segmentation used in conjunction with LMD to increase discovery throughput.

Biomarker Discovery with Laser Microdissection

Explore the potential of spatial proteomics workflows, such as Deep Visual Proteomics (DVP), to decipher pathology mechanisms and uncover druggable targets. Altered protein expression, abundance, or…
Brain organoid labeled with lamin (green) and tubulin (magenta), acquired using Viventis Deep. Courtesy of Akanksha Jain, Treutlein Lab ETH-DBSSE Basel (Switzerland).

Faster & Deeper Insights into Organoid and Spheroid Models

Gain deeper, more translatable, insights into organoid and spheroid models for drug discovery and disease research by overcoming key imaging challenges. In this eBook, explore advanced microscopy…
Final Segmentation of organelles in Trichomonas species. Magenta – costa, light blue – hydrogenosomes, turquoise – ER, red – vacuoles, yellow – axostyle, green – Golgi apparatus. Sample courtesy of Isabelle Guerin-Bonne, Low Kay En, Electron Microscopy Unit, Yong Loo Lin School of Medicine, National University of Singapore. Scale bar: 1 µm.

Volume EM and AI Image Analysis

The article outlines a detailed workflow for studying biological tissues in three dimensions using volume-scanning electron microscopy (volume-SEM) combined with AI-assisted image analysis. The focus…
Image of roundworm C. elegans acquired with a M205 FA fluorescence automated stereo microscope in combination with Rottermann contrast. Areas labelled with mCherry are seen as reddish purple.

A Guide to C. elegans Research – Working with Nematodes

Efficient microscopy techniques for C. elegans research are outlined in this guide. As a widely used model organism with about 70% gene homology to humans, the nematode Caenorhabditis elegans (also…
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