Science Lab

Science Lab

Science Lab

Bienvenido al portal de conocimiento de Leica Microsystems. Aquí encontrará investigación científica y material didáctico sobre el tema de la microscopía. El portal ayuda a principiantes, profesionales experimentados y científicos por igual en su trabajo diario y en sus experimentos. Explore tutoriales interactivos y notas de aplicación, descubra los fundamentos de la microscopía, así como las tecnologías de gama alta. Forme parte de la comunidad Science Lab y comparta sus conocimientos.
Hepatocellular Carcinoma with 13 biomarkers shown – Beta-Catenin, CD3D, CD4, CD8a, CD31, CD44, CD163, DAPI, PanCK, PCK26, PD1, SMA, and Vimentin.

Understanding Tumor Heterogeneity with Protein Marker Imaging

Explore tumor heterogeneity and immune cell dynamics. See how quantitative imaging analysis reveals spatial relationships and molecular insights crucial for advancing cancer research and therapeutics.
Adult human Alzheimer’s brain demonstrating a panel of 15 markers.

The Shape of the Brain: Spatial Biology of Alzheimer’s Disease

Uncover cell identity and brain structure in Alzheimer's disease with Cell DIVE multiplexed imaging, demonstrating how spatial biology can lead to advances in therapy development for…
Co-detection of 10 extracellular matrix proteins and 3 topographical tissue landmarks by multiplex immunostaining within a single high-grade fibrous hotspot from a human hepatocellular carcinoma

Mapping Cancer Stem Cell Niches in Hepatocellular Carcinoma

Discover how multiplexed imaging technology uncovers cancer stem cell niches in Hepatocellular Carcinoma using multiplex immunodetection, revealing extracellular matrix dynamics. Explore precise…
Application example of hyperspectral imaging

Potential of Multiplex Confocal Imaging for Cancer Research and Immunology

Explore the new frontiers of multi-color fluorescent imaging: from image acquisition to analysis
Single cell datasets

Exploring Subcellular Spatial Phenotypes with SPARCS

Discover spatially resolved CRISPR screening (SPARCS), a platform for microscopy-based genetic screening for spatial subcellular phenotypes at the human genome scale.
Pancreatic Ductal Adenocarcinoma with 11 Apoptosis biomarkers shown – BAK, BAX, BCL2, BCLXL, Caspase9, CIAP1, NaKATPase, PCK26, SMAC, Vimentin, and XIAP.

Multiplexing with Luke Gammon: Advance your Spatial Biology Research

Learn how multiplexing imaging and spatial biology can help researchers better understand complex biological systems. In this interview, Dr. Gammon and Dr. Pointu of Leica Microsystems discuss pain…
Multi-tissue array with 4 markers shown including DAPI, NaKATPase, PanCk, and Vimentin.

Spatial Biology: Learning the Landscape

Spatial Biology: Understanding the organization and interaction of molecules, cells, and tissues in their native spatial context
Mouse cortical neurons. Transgenic GFP (green). Image courtesy of Prof. Hui Guo, School of Life Sciences, Central South University, China

How Microscopy Helps the Study of Mechanoceptive and Synaptic Pathways

In this podcast, Dr Langenhan explains how microscopy helps his team to study mechanoceptive and synaptic pathways, their challenges, and how they overcome them.
Cell counts for each biomarker were divided by total number of cells to give a percentage of biomarker positive cells out of total cells for each biomarker.

Methods to Improve Reproducibility in Spatial Biology Research

Establish reproducibility results for a Cell DIVE multiplexed imaging study in cancer research using the BAB 200 automated system from ASLS and validated antibodies from CST
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