Medical Specialties

Medical Specialties

Medical Specialties

Explore a comprehensive collection of scientific and clinical resources tailored for HCPs, including peer insights, clinical case studies, and symposia. Designed for neurosurgeons, ophthalmologists, and specialists in Plastic and Reconstructive surgery, ENT, and dentistry. This collection highlights the latest advancements in surgical microscopy. Discover how cutting-edge surgical technologies, such as AR fluorescence, 3D visualization, and intraoperative OCT imaging, empower confident decision-making and precision in complex surgeries.
EM Sample Preparation Coating, Etching and Fracturing

Sample Preparation for EM: A Practical Guide to Coating and Freeze-Fracturing

From coatings done in a low-vacuum sputter coating machine at room-temperature to those done in high-vacuum and even at cryogenic temperatures, Leica coating solutions cover a large range of needs.…
Array tomography image of T-cells in mouse lymph nodes.

High Resolution Array Tomography with Automated Serial Sectioning

The optimization of high resolution, 3-dimensional (3D), sub-cellular structure analysis with array tomography using an automated serial sectioning solution, achieving a high section density on the…

Visualization of DNA Molecules

Precise low angle rotary shadowing with heavy metals (like platinum) can be used in transmission electron microscopy (TEM) to observe molecular details of objects previously absorbed on a thin, low…

Each Atom Counts: Protect Your Samples Prior to FIB Processing

Application Note for Leica EM ACE600 - Focused ion beam (FIB) technology has become an indispensable tool for site-specific TEM sample preparation. It allows to extract electron transparent specimens…

Imaging of Host Cell-bacteria Interactions using Correlative Microscopy under Cryo-conditions

Pathogenic bacteria have developed intriguing strategies to establish and promote infections in their respective hosts. Most bacterial pathogens initiate infectious diseases by adhering to host cells…

Brief Introduction to Freeze Fracture and Etching

Freeze fracture describes the technique of breaking a frozen specimen to reveal internal structures. Freeze etching is the sublimation of surface ice under vacuum to reveal details of the fractured…

Brief Introduction to Specimen Trimming

Before ultrathin sectioning a sample with an ultramicrotome it has to be pre-prepared. For this pre-preparation, special attention must be paid to the sample size (size of the section), location of…

Glycerol Spraying/Platinum Low Angle Rotary Shadowing of DNA with the Leica EM ACE600 e-beam

Glycerol spraying/low angle rotary shadowing (Aebi and Baschong, 2006) is a preparation technique used in biology to visualize structures yielding insufficent contrast with other techniques, due to…

Brief Introduction to Coating Technology for Electron Microscopy

Coating of samples is required in the field of electron microscopy to enable or improve the imaging of samples. Creating a conductive layer of metal on the sample inhibits charging, reduces thermal…
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