Science Lab

Science Lab

Science Lab

Willkommen auf dem Wissensportal von Leica Microsystems. Hier finden Sie wissenschaftliches Forschungs- und Lehrmaterial rund um das Thema Mikroskopie. Das Portal unterstützt Anfänger, erfahrene Praktiker und Wissenschaftler gleichermaßen bei ihrer täglichen Arbeit und ihren Experimenten. Erkunden Sie interaktive Tutorials und Anwendungshinweise, entdecken Sie die Grundlagen der Mikroskopie ebenso wie High-End-Technologien. Werden Sie Teil der Science Lab Community und teilen Sie Ihr Fachwissen.

Vom Licht zur Erleuchtung: Sensoren und Messverfahren in der konfokalen Mikroskopie

In diesem Beitrag werden die wichtigsten Sensoren kurz vorgestellt, die in der konfokalen Mikroskopie verwendet werden. Mit konfokaler Mikroskopie ist hier „True Confo-cal Scanning“ gemeint, also das…
Acousto-optics, sketch

Acousto Optics in True Confocal Spectral Microscope Systems

Acousto-optical elements have successfully replaced planar filters in many positions. The white confocal, regarded as the fully spectrally tunable confocal microscope, was not possible without this…

Nobel Prize 2013 in Physiology or Medicine for Discoveries of the Machinery Regulating Vesicle Traffic

On October 7th 2013, The Nobel Assembly at Karolinska Institutet has decided to award The Nobel Prize in Physiology or Medicine 2012 jointly to James E. Rothman, Randy W. Schekman and Thomas C. Südhof…

Handbook of Optical Filters for Fluorescence Microscopy

Fluorescence microscopy and other light-based applications require optical filters that have demanding spectral and physical characteristics. Often, these characteristics are application-specific and…

Spectral Detection – How to Define the Spectral Bands that Collect Probe-specific Emission

To specifically collect emission from multiple probes, the light is first separated spatially and then passes through a device that defines a spectral band. Classically, this is a common glass-based…

Step by Step Guide for FRAP Experiments

Fluorescence Recovery After Photobleaching (FRAP) has been considered the most widely applied method for observing translational diffusion processes of macromolecules. The resulting information can be…
Sub-Femtolitre volume_Fluorescence correlation spectroscopy (FCS)

Fluorescence Correlation Spectroscopy (FCS)

Fluorescence correlation spectroscopy (FCS) measures fluctuations of fluorescence intensity in a sub-femtolitre volume to detect such parameters as the diffusion time, number of molecules or dark…
Live cell imaging, 4 colors: Mitochondria (MitoView Green, yellow) and actin (mNeonGreen, cyan) microtubuli (SIR-tubulin, magenta), endosomes (NIR750, green). Processed with DSE and DSE powered by Aivia.

The Principles of White Light Laser Confocal Microscopy

The perfect light source for confocal microscopes in biomedical applications has sufficient intensity, tunable color and is pulsed for use in lifetime fluorescence. Furthermore, it should offer means…

Confocal Optical Section Thickness

Confocal microscopes are employed to optically slice comparably thick samples.
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