Compound Light Microscopes

Compound light microscopes from Leica Microsystems meet the highest demands whatever the application – from routine laboratory work to the research of multi-dimensional dynamic processes in living cells.

Compound Light Microscopes

Upright Microscopes

Inverted Microscopes

Stereo Microscopes

Automated Microscopes

DM4 B & DM6 B

Enhance your life-science and clinical research with the DM4 B and DM6 B upright microscopes. With flexible software solutions, they allow you to focus on experiments while reducing manual work.

M50, M60 & M80

Routine stereo microscopes

Ivesta 3

Greenough Stereo Microscopes. Optimize visual inspection and rework while achieving reliable, consistent results.

A60 F & A60 S

Industrial Stereo Microscopes for Electronics and Medical Device Manufacturing

Visoria M

Experience enhanced efficiency and comfort in your daily microscopy routine. The Visoria M materials microscope is for applications performed in the metal, electronics, and polymer industries as well...

Visoria P

Experience enhanced efficiency and comfort in your daily microscopy routine. The Visoria P polarization microscope uses polarized light to study the optical properties of materials and geological...

Visoria B

Experience enhanced efficiency and comfort in your daily microscopy routine. The Visoria B laboratory microscope is for applications performed in life science and clinical laboratories.

THUNDER Imager Cell Spinning Disk

Discover the power of combining THUNDER technology with the CrestOptics CICERO spinning disk.

DMi8

DMi8 inverted microscope platform enables you to generate high quality data with solutions tailored to your research requirements and budget.

Leica DM4 M & DM6 M

Upright Materials Microscopes

M125 C, M205 C & M205 A

Encoded Stereo Microscopes

DM8000 M & DM12000 M

Detect defects and carry out sample overviews quickly with the reliable DM8000 M & DM12000 M inspection microscopes.

Mateo Fl, Mateo TL

Integrated inverted digital microscopes for cell culture research with AI-assisted workflows for consistent cell culture analysis.

MZ10 F

Modular stereomicroscope for fluorescent imaging

Leica EZ4 W & EZ4 E

Stereo microscope for college and university education with 8x to 35x magnification, 7-way LED illumination, and integrated camera

EZ4

Stereo microscope for beginners in college and university education with 8x to 35x magnification and 7-way LED illumination

DM500

Binocular educational microscope for life science students with 4 infinity-corrected plan-achromat objectives and fluorescence capability

DM750

Binocular educational microscope for life science postdocs with 4 or 5 infinity-corrected or HI plan-achromat objectives and fluorescence capability

DM1000

Uniquely Ergonomic System Microscope

THUNDER Imager Cell

THUNDER Imagers provide you with a solution for advanced 3D cell culture assays, whether you want to study stem cells, spheroids, or organoids.

DM4 P, DM750 P & Visoria P

Polarization Microscopes

DMi1

Entry level inverted microscope

DM IL LED

Inverted Laboratory Microscope with LED Illumination

THUNDER Imager Model Organism

The THUNDER Imager Model Organism allows fast and easy 3D exploration of whole organisms for developmental or molecular biology research.

Leica M205 FCA & Leica M205 FA

(Semi)-automated fluorescence stereo microscopes

Leica DM4 B & DM6 B

Increase work efficiency with Leica DM4 B & DM6 B upright digital research microscopes.

Cell DIVE

Multiplex imaging solution Cell DIVE offers crystal-clear whole tissue images, the visualization of 60+ biomarkers and over 350 validated antibodies.

Mica

Mica - The world’s first Microhub. Everything you need to enable discoveries, unified in one easy-to-use system. Simultaneous 4-color widefield, confocal resolution, AI supported analysis.

STELLARIS Cryo

STELLARIS Cryo is a confocal light microscope system that helps you to target your area of interest for cryo-electron tomography (CryoET)

THUNDER Imager Tissue

The THUNDER Imager Tissue allows real-time fluorescence imaging of 3D tissue sections typically used in neuroscience and histology research.

Leica LMD Systems

Laser Microdissection enables users to isolate specific single cells or entire areas of tissue.

FS M

Manual Forensic Comparison Macroscope

DM ILM

Inverted Microscope for Metallography and Industrial Materials Inspection

FS4000 LED

Forensic Comparison Microscope with LED Illumination

FS C & FS M

Comparison macroscopes for examination of forensic evidence

FS CB

Motorized Forensic Comparison Microscope

Leica DMi8 M / C / A

Inverted Microscopes for Industry

LAS X Steel Expert

Steel Analysis Software

DM1000 LED

Uniquely ergonomic system microscope with LED illumination

LAS X Widefield Systems

Fluorescence Microscope System for Advanced Imaging and Analysis

DM6 FS

Fixed Stage Microscope for Electrophysiology and in vivo Imaging

M165 FC

Fluorescent stereomicroscope

Leitz Optilux

View the Finest Details - Compound Microscope

DM750 M

Binocular materials microscope for education, basic metallography, and forensics education

Read our latest articles about Light Microscopes

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments.

Ensuring Glass Quality with the Polarization Microscopy Advantage

Glass is one of the oldest materials known. Today, it is used for many applications, e.g., optical instruments, windows, doors, solar panels, containers for food, beverages, and medicine, so strict standards for glass quality must be met, especially for optics. Quality control of flat, hollow, and pressed glass with polarization microscopy is fast and cost-effective. Defects, like knot, metallic, and crystalline inclusions and bubbles, can be analyzed without time-consuming sample preparation.

A Guide to Fluorescence Microscopy

Fluorescence microscopy uses the ability of fluorophores, dyes, or fluorescent proteins to emit light of a specific wavelength after being excited with light of a shorter wavelength. Biomolecules can be marked with antibody staining or fluorescent-protein tagging. The distribution of single molecules inside cells can be determined, molecular interactions studied, ion concentrations quantified, and cellular processes observed. Even optical microscope resolution can be improved with fluorescence.

How to Select the Right Measurement Microscope

With a measurement microscope, users can measure the size and dimensions of sample features in both 2D and 3D, something crucial for inspection, QC, failure analysis, and R&D. However, choosing the right microscope involves assessing application needs along with microscope performance, ease of use, and flexibility. Today, measurements are often made digitally, i.e., a microscope with a camera and software and images displayed on a monitor, rather than via an eyepiece reticule, leading to increased precision and repeatability. Analyze samples reliably and quickly with the right measurement microscope.

Microscope Calibration for Measurements: Why and How You Should Do It

Microscope calibration ensures accurate and consistent measurements for inspection, quality control (QC), failure analysis, and research and development (R&D). Calibration steps are described in this article. Using a reference, calibration enables reproducible results and helps ensure agreement with guidelines and standards. To attain accurate and consistent results, it is recommended to calibrate a microscope and regularly check it. If needed, support can be obtained from calibration experts.

Visualizing Photoresist Residue and Organic Contamination on Wafers

As the scale of integrated circuits (ICs) on semiconductors passes below 10 nm, efficient detection of organic contamination, like photoresist residue, and defects during wafer inspection is becoming more crucial. Optical microscopy is still the common inspection method, but for organic contamination brightfield and other types of illumination can have limitations. How fluorescence microscopy is used to efficiently detect photoresist residues and other organic contamination on wafers during QC, failure analysis, and R&D for the semiconductor industry is discussed in this article.

Rapidly Visualizing Magnetic Domains in Steel with Kerr Microscopy

The rotation of polarized light after interaction with magnetic domains in a material, known as the Kerr effect, enables the investigation of magnetized samples with Kerr microscopy. It allows rapid visualization of magnetic domains at the material’s surface. For efficient R&D and QC of magnetic materials, e.g., steel alloys, used in electrical and electronic devices, Kerr microscopy can play an important role. More details about how Kerr microscopy can be used to image magnetic domains in the grains of steel alloys is described in this article.

6-Inch Wafer Inspection Microscope for Reliably Observing Small Height Differences

A 6-inch wafer inspection microscope with automated and reproducible DIC (differential interference contrast) imaging, no matter the skill level of users, is described in this article. Manufacturing of integrated-circuit (IC) chips and semiconductor components requires wafer inspection to verify no defects are present which affect performance. The inspection is often done with optical microscopy for QC, failure analysis, and R&D. To visualize efficiently small height differences between structures on wafers, DIC can be used.

Burr Detection During Battery Manufacturing

See how optical microscopy can be used for burr detection on battery electrodes and determination of damage potential to achieve rapid and reliable quality control during battery manufacturing.

Guide to Live-Cell Imaging

For a wide range of applications in various research fields of life science, live-cell imaging is an indispensable tool for visualizing cells in a state as close to in vivo, i.e. living and active, as possible. This guide reviews a wide range of important considerations for ensuring successful live-cell imaging and introduces a variety of high-performance solutions designed to overcome common challenges. These advances enable new insights into cellular physiology and dynamics.

Factors to Consider When Selecting a Research Microscope

An optical microscope is often one of the central devices in a life-science research lab. It can be used for various applications which shed light on many scientific questions. Thereby the configuration and features of the microscope are crucial for its application coverage, ranging from brightfield through fluorescence microscopy to live-cell imaging. This article provides a brief overview of the relevant microscope features and wraps up the key questions one should consider when selecting a research microscope.

Infinity Optical Systems - From “Infinity Optics” to the Infinity Port

“Infinity Optics” is the concept of a light path with parallel rays between the objective and tube lens of a microscope [1]. Placing flat optical components into this “infinity space” which do not influence image formation is critical for contrast methods, like DIC or fluorescence, often used for scientific applications. The addition of instruments, such as light sources or laser devices, into the infinite light path is required. Different approaches to fulfill this need are described here.

AI meets Deep Visual Proteomics (DVP) to Advance Disease Research

In this webinar, Dr. Andreas Mund will introduce a cutting-edge platform that merges Deep Visual Proteomics (DVP) with AI-powered pathology models, enabling high-resolution mapping of key regions in complex clinical tissue samples to decode disease mechanisms at the cellular level. He will demonstrate how DVP identifies thousands of proteins from minimal, phenotype-matched cell populations, forming detailed, spatially resolved proteomic maps of disease progression.

Microscopy and AI Solutions for 2D Cell Culture

This eBook explores the integration of microscopy and AI technologies in 2D cell culture workflows. It highlights how traditional imaging methods—such as brightfield, phase contrast, and fluorescence—support routine cell monitoring, while digital platforms like the Mateo TL and FL enhance reproducibility through automated confluency checks, cell counting, and transfection analysis. It also shows how integrated data management, audit trails, and sample tracking improve documentation and research integrity. The book concludes with a look at future trends, including microfluidics and hybrid 2D–3D systems, emphasizing the growing need for advanced imaging tools to meet evolving research demands.

AI-Powered Hi-Plex Spatial Analysis Tools for Breast Cancer Research

Breast cancer (BC) is the leading cause of cancer-related deaths in women. Investigating the tumor microenvironment (TME) is crucial to elucidate the mechanisms of tumor progression. Systematic mapping of the TME using hi-plex spatial proteomics could empower precision immuno-oncology. Herein, we apply AI-based hi-plex spatial analysis on BC tissue to study immune cell types and biomarkers that could provide insight into molecular components of the TME that influence response to immunotherapy.

Polarizing Microscope Image Gallery

How polarization microscope images can be used for analysis is shown in this gallery. Polarized light microscopy (also known as polarizing microscopy) is an important method for different fields and applications. It goes beyond high magnification and resolution imaging typically done with conventional optical microscopy. By examining a sample’s color, birefringence, and other optical properties, additional information about its structure, material properties, and composition can be obtained.

Biomarker Discovery with Laser Microdissection

Explore the potential of spatial proteomics workflows, such as Deep Visual Proteomics (DVP), to decipher pathology mechanisms and uncover druggable targets. Altered protein expression, abundance, or activity can significantly impact cellular function—often contributing to disease. Remarkably, the proteome can vary dramatically between neighboring cells. Spatial proteomics accounts for this cellular heterogeneity to reveal pathological mechanisms. Laser Microdissection (LMD) enables access to single cells for downstream analysis while preserving their spatial context—forming the foundation of spatial proteomics.

Key Questions

1What is your application?

The Leica compound light microscope you need depends on your application. The demands of different applications are best met by different light microscopes and light microscope parts. The modular design of Leica light microscopes enable a customized solution to be set up for a specific application.

2Which type of samples do you need to visualize?

Whether you are observing samples for routine laboratory work, materials production or analysis, or complex life science research, the optical resolution, contrast, depth of field, and image quality you need are provided by Leica light microscope solutions. Additionally, light microscope parts and accessories, such as objectives, illumination types, and digital cameras, along with the Leica Application Suite software, can further customize and optimize the solution for your specific application needs.

3What about the budget for the light microscope solution?

Customized light microscope solutions can lead to higher investment costs, but they allow you and your colleagues to increase productivity. A microscope solution can be optimized essentially for almost any application due to a large variety of light microscopes, light microscope parts, and accessories.

4What is the difference between a compound light microscope and stereo microscope?

A compound light and stereo microscope both use optics with an objective lens and eyepieces or oculars for viewing the image of the sample. In general, a compound light microscope achieves a higher range of magnification than a stereo. There is only one light channel for viewing the sample with a compound microscope, so a 2D image is seen. A stereo microscope has two light channels, one for each eye of the observer, which enable a 3D image of the sample to be seen. If either a compound or stereo microscope is equipped with a camera, then just one light channel is used and only a 2D image can be recorded.

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The Leica coded stereo microscopes M125 C, M205 C and M205 A help you to pave the way to correct results.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/stereo-microscopes\/p\/leica-m125-c\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/c\/4\/csm_Leica_M205_A_Encoded-Stereomicroscope_list_19fcc8993c.jpg\n ","squareImage":0,"applications":[{"title":"Automotive & Aerospace Microscopy Solutions","link":"\/applications\/industrial-microscopy-markets\/automotive-aerospace\/"},{"title":"PCB Inspection","link":"\/applications\/industrial-microscopy-markets\/electronics-semiconductor\/pcb-inspection\/"},{"title":"Technical Cleanliness Microscopes","link":"\/applications\/industrial-microscopy-markets\/industrial-applications\/technical-cleanliness\/"},{"title":"Inspection Microscopes","link":"\/applications\/industrial-microscopy-markets\/industrial-applications\/inspection-microscopes\/"},{"title":"Measurement Microscopes","link":"\/applications\/industrial-applications\/measurement-microscopes\/"},{"title":"Art Conservation Microscope Solutions","link":"\/applications\/industrial-microscopy-markets\/industrial-applications\/art-conservation\/"},{"title":"Medical Device QA & QC Microscopy Solutions","link":"\/applications\/industrial-microscopy-markets\/medical-device-qa-qc\/"}]},{"id":"cs64176","title":"DM8000 M & DM12000 M","subtitle":"Detect defects and carry out sample overviews quickly with the reliable DM8000 M & DM12000 M inspection microscopes.","abstract":"\u003Cp\u003EImprove your decision-making for product quality and save time by gaining deeper insights into samples with the DM8000 M and DM12000 M optical inspection systems.\u003C\/p\u003E\r\n\u003Cp\u003EThese inspection microscopes offer fast and reliable inspection and analysis of materials like semiconductors and wafers, enabling you to perform quality control and detect defects fast.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/dm8000-12000\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/5\/6\/csm_DM8000-12000-Inspection-Microscopes-list_27ae0a7149.jpg\n ","squareImage":0,"applications":[{"title":"Inspection Microscopes","link":"\/applications\/industrial-microscopy-markets\/industrial-applications\/inspection-microscopes\/"},{"title":"Semiconductor Inspection","link":"\/applications\/industrial-microscopy-markets\/electronics-semiconductor\/semiconductor-inspection\/"}]},{"id":"cs64133","title":"Mateo Fl, Mateo TL","subtitle":"Integrated inverted digital microscopes for cell culture research with AI-assisted workflows for consistent cell culture analysis.","abstract":"\u003Cp\u003EKeep your lab ahead of the digital innovation curve with our specialized digital solutions designed to streamline even the most advanced cell culture applications. \u003C\/p\u003E\r\n\u003Cp\u003EWith a range of automated analysis tools and modalities, the Mateo family of digital inverted microscopes offers you the power and flexibility to choose the solution that's right for your needs.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/mateo\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/7\/9\/csm_Mateo-digital-fluorescence-stageV2_feafc4c6a6.jpg\n ","squareImage":0,"applications":[{"title":"Microscopy Solutions for Cell Culture","link":"\/applications\/life-science\/cell-culture\/"},{"title":"Biopharma","link":"\/applications\/life-science\/biopharma\/"},{"title":"Structure and Physiology of Organoids and 3D Cell Culture","link":"\/applications\/life-science\/structure-and-physiology-of-organoids-and-3d-cell-culture\/"}]},{"id":"cs286","title":"MZ10 F","subtitle":"Modular stereomicroscope for fluorescent imaging","abstract":"\u003Cp\u003EThe Leica MZ10 F modular stereo microscope with 8x-80x magnification and 375 Lp\/mm high resolution provides triple beam technology, which designates a separate beam path specifically for fluorescent illumination for high contrast and detailed fluorescent imaging.\u003C\/p\u003E\r\n\u003Cp\u003EWith the \u003Cstrong\u003EFLUOIII\u2122\u003C\/strong\u003E rapid filter changer, which allows fast interchange between triple beam standard or custom filter sets, the Leica MZ10 F is the ideal tool for fluorescence applications such as gene expression studies or developmental biology applications.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/stereo-microscopes\/p\/leica-mz10-f\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/f\/3\/csm_Leica_MZ10_F_Modular_stereomicroscope_list_665027b444.jpg\n ","squareImage":0,"applications":[]},{"id":"cs46377","title":"Leica EZ4 W & EZ4 E","subtitle":"Stereo microscope for college and university education with 8x to 35x magnification, 7-way LED illumination, and integrated camera","abstract":"\u003Cp\u003EThese stereo microscopes provide a wireless education solution to the science classroom. The integrated 5-megapixel cameras can live-stream HD images to students\u2019 smartphones or tablets. Students can connect to the EZ4 W either through its own internal Wi-Fi signal or through the facilities network. The EZ4 E exclusively uses the facilities network (WLAN or LAN) to allow students to connect to the microscope. This is an ideal solution if you don`t want to add additional Wi-Fi access points to your existing wireless network concept.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/stereo-microscopes\/p\/leica-ez4-w\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/d\/3\/csm_leica-ez4-w_c390f323e6.jpg\n ","squareImage":0,"applications":[{"title":"Educational Microscopes","link":"\/applications\/education\/"}]},{"id":"cs150","title":"EZ4","subtitle":"Stereo microscope for beginners in college and university education with 8x to 35x magnification and 7-way LED illumination","abstract":"\u003Cp\u003EThe Leica EZ4 educational stereomicroscope with 4.4:1 zoom for entry level university and college courses such as biology, anatomy and chemistry provides over 20 years of bright LED illumination which saves time and cost of replacement bulbs.\u003C\/p\u003E\r\n\u003Cp\u003E7-way LED illumination system provides incident, oblique and transmitted light for high quality illumination and contrast of any application. Greenough optical system provides a 3 dimensional view of sample.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/stereo-microscopes\/p\/leica-ez4\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/a\/2\/csm_leica-ez4_01_eb32ab32aa.jpg\n ","squareImage":0,"applications":[]},{"id":"cs76","title":"DM500","subtitle":"Binocular educational microscope for life science students with 4 infinity-corrected plan-achromat objectives and fluorescence capability","abstract":"\u003Cp\u003EThe DM500 microscope with \u201cplug and play\u201d capability is the ideal tool to make teaching entry-level college and university Life Science courses easy and fun for the instructor and the student. Student-friendly features such as the pre-focused, pre-centered condenser and the EZTube\u2122 preset diopter, which prevent incorrect adjustments, provide more time for hands-on teaching. EZStore\u2122 design with integrated handle and cord wrap allows easy carrying, easy lifting and protection against microscope component damage. \u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/leica-dm500\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_migrated\/Products\/leica-dm500-education-micro.jpg\n ","squareImage":0,"applications":[{"title":"Educational Microscopes","link":"\/applications\/education\/"}]},{"id":"cs82","title":"DM750","subtitle":"Binocular educational microscope for life science postdocs with 4 or 5 infinity-corrected or HI plan-achromat objectives and fluorescence capability","abstract":"\u003Cp\u003EBinocular educational microscope for life science postdocs with 4 or 5 infinity-corrected or HI plan-achromat objectives and fluorescence capability. The Leica DM750 is the ideal microscope for the versatile needs of advanced college and university life science courses and professional training in medical, veterinary and dental schools.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/leica-dm750\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/2\/1\/csm_leica-dm750_16a662f82f.jpg\n ","squareImage":0,"applications":[{"title":"Educational Microscopes","link":"\/applications\/education\/"}]},{"id":"cs65","title":"DM1000","subtitle":"Uniquely Ergonomic System Microscope","abstract":"\u003Cp\u003EThe ergonomically designed Leica DM1000 with adjustable features and easy-to-use controls adapts to every user to improve comfort and convenience while working at the microscope.\u003C\/p\u003E\r\n\u003Cp\u003EFeaturing high-quality optical performance, the Leica DM1000 is ideal for all clinical laboratory applications, in particular cytology, haematology, and pathology. For special diagnostics requirements, the microscope is certified for in-vitro-diagnostics (IVD) like in-vitro-fertilization (IVF). Its advanced capabilities, including fluorescence, make it well suited also for complex tasks.\u003C\/p\u003E\r\n\r\n","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/leica-dm1000\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/c\/d\/csm_lms-dm1000_card-image_2bfdf2a71a.jpg\n ","squareImage":0,"applications":[{"title":"Clinical Pathology","link":"\/applications\/clinical-laboratories\/clinical-pathology\/"},{"title":"Anatomic Pathology","link":"\/applications\/clinical-laboratories\/anatomic-pathology\/"}]},{"id":"cs53746","title":"THUNDER Imager Cell","subtitle":"THUNDER Imagers provide you with a solution for advanced 3D cell culture assays, whether you want to study stem cells, spheroids, or organoids.","abstract":"\u003Cp\u003EWith THUNDER Imagers you begin every experiment with confidence. They are your solution for advanced 3D cell culture assays, whether you want to study stem cells, spheroids, or organoids.\u003C\/p\u003E\r\n\u003Cp\u003ETHUNDER Imagers feature innovative Leica technology Computational Clearing. It efficiently removes out-of-focus blur in real time, enabling the meaningful use of 3D specimens with camera-based fluorescence microscopes.\u003C\/p\u003E\r\n\u003Cp\u003EThe high sensitivity of the system ensures low phototoxicity for physiologically relevant data sets. THUNDER systems offer a range of tools that assist you throughout your workflow from set up to data analysis.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/thunder-imaging-systems\/p\/thunder-imager-cell\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/3\/a\/csm_THUNDER_Imager_Live_Cell3-2_35553e61fe.jpg\n ","squareImage":0,"applications":[{"title":"Structure and Physiology of Organoids and 3D Cell Culture","link":"\/applications\/life-science\/structure-and-physiology-of-organoids-and-3d-cell-culture\/"}]},{"id":"cs47281","title":"DM4 P, DM750 P & Visoria P","subtitle":"Polarization Microscopes","abstract":"\u003Cp\u003EIf you would like to investigate crystalline structures, polarization microscopy will serve you best. Whether it be minerals, plastics and polymers, drugs and pharmaceuticals, or pigments and cement, with our polarization microscopes you will see what interests you most as a researcher or in quality assurance.\u003C\/p\u003E\r\n\r\n","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/leica-dm4-p\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/a\/f\/csm_Leica_Polarization-Microscopes_list_a810e9dabb.jpg\n ","squareImage":0,"applications":[{"title":"Microscopes for Energy, Mining and Natural Resources","link":"\/applications\/industrial-microscopy-markets\/industrial-applications\/energy-mining-and-natural-resources\/"},{"title":"Metal Industry Microscopy Solutions","link":"\/applications\/industrial-microscopy-markets\/metal-industry\/"},{"title":"Material Science & Analysis","link":"\/applications\/industrial-microscopy-markets\/industrial-applications\/material-science-analysis\/"}]},{"id":"cs34845","title":"DMi1","subtitle":"Entry level inverted microscope","abstract":"\u003Cp\u003EThe DMi1 inverted microscope supports your specific work routine in your \u003Ca href=\"t3:\/\/page?uid=19686\"\u003Ecell culture\u003C\/a\u003E lab. Its operation is so intuitive, its handling so comfortable that you can fully concentrate on your work. Choose the functions you need, and, if necessary, you can easily add a variety of accessories that are important for your work.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/leica-dmi1\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/7\/8\/csm_leica-dmi1_01_27f078d4b1.jpg\n ","squareImage":0,"applications":[{"title":"Microscopy Solutions for Cell Culture","link":"\/applications\/life-science\/cell-culture\/"}]},{"id":"cs94","title":"DM IL LED","subtitle":"Inverted Laboratory Microscope with LED Illumination ","abstract":"\u003Cp\u003EIdeal for cell culture, micromanipulation, documentation of immunostained specimens, and routine live cell examinations. Monitor your specimen the way you need: Phase contrast, modulation contrast and fluorescence are just one fingertip away.\u003C\/p\u003E\r\n\u003Cp\u003ERobust stability, plenty of space to work with tools, long working distances to accommodate large culture flasks and a stable illumination without heat make work at the microscope easy and convenient.\u003C\/p\u003E\r\n\u003Cp\u003EFor special diagnostics requirements, the microscope is certified for in-vitro-diagnostics (IVD) including in-vitro-fertilization (IVF).\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/leica-dm-il-led\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/9\/1\/csm_leica-dm-il-led_03_9c9170ef44.jpg\n ","squareImage":0,"applications":[{"title":"Microscopy Solutions for Cell Culture","link":"\/applications\/life-science\/cell-culture\/"}]},{"id":"cs53754","title":"THUNDER Imager Model Organism","subtitle":"The THUNDER Imager Model Organism allows fast and easy 3D exploration of whole organisms for developmental or molecular biology research.","abstract":"\u003Cp\u003EThe THUNDER Imager Model Organism allows fast and easy 3D exploration of whole organisms for developmental or molecular biology research. Thanks to THUNDER Live, your images reveal the finest structural details already in the live image. No hassle with out-of-focus blur while maintaining the capabilities and ease-of-use typical for Leica stereo microscopes.\u003C\/p\u003E\r\n\u003Cp\u003EA THUNDER Imager Model Organism is the optimal instrument for studying, e.g., \u003Ci\u003EDrosophila\u003C\/i\u003E, \u003Ci\u003EC. elegans\u003C\/i\u003E, zebrafish, plants, and mice. One device for screening, positioning, and imaging your specimen. Simplify your workflow and study model organisms from a large overview to the highest detail.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/thunder-imaging-systems\/p\/thunder-imager-model-organism-sensitive\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/2\/2\/csm_THUNDER_Imager_Model_Organism_Mouse_list_6b5bf8c60e.jpg\n ","squareImage":0,"applications":[]},{"id":"cs52229","title":"Leica M205 FCA & Leica M205 FA","subtitle":"(Semi)-automated fluorescence stereo microscopes","abstract":"\u003Cp\u003EDo you sometimes feel like fishing in the dark because you are looking for fluorescence signals that are increasingly faint and weak? We have developed M205 FA and M205 FCA fluorescence stereo microscopes to enable you to detect transgenic expression like GFP and mCherry in early stages, allowing you to select the right sample to successfully base your studies on.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/stereo-microscopes\/p\/leica-m205-fca\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/7\/0\/csm_leica-m205-fca_15913cc930.jpg\n ","squareImage":0,"applications":[]},{"id":"cs47282","title":"Leica DM4 B & DM6 B","subtitle":"Increase work efficiency with Leica DM4 B & DM6 B upright digital research microscopes.","abstract":"\u003Cp\u003EIncrease your work efficiency with the Leica DM4 B or Leica DM6 B upright digital research microscopes! Both are ideally suited to making your work life easier in biomedical research and clinical labs alike.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/leica-dm6-b\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/f\/9\/csm_leica-dm4-b_044517d1c9.jpg\n ","squareImage":0,"applications":[]},{"id":"cs62310","title":"Cell DIVE","subtitle":"Multiplex imaging solution Cell DIVE offers crystal-clear whole tissue images, the visualization of 60+ biomarkers and over 350 validated antibodies.","abstract":"\u003Cp\u003EWhat if every scientist could map normal and diseased tissue by cell type, biomarker profile, and specific features?\u003C\/p\u003E\r\n\u003Cp\u003ECell DIVE is a precise, open multiplexing solution that lets your research dictate the level of automation required, which antibodies to use, how to build your antibody panel and more.\u003C\/p\u003E\r\n\u003Cp\u003ECell DIVE keeps evolving to support your ever-changing research needs. With new technical innovations in software and automation, you can get more out of every experiment.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/cell-dive\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/6\/5\/csm_LMSPR008_Image1_Cell_DIVE_Multiplexed_Imaging_Solution_593d642098.jpg\n ","squareImage":0,"applications":[{"title":"Cellular Analysis","link":"\/applications\/life-science\/cellular-analysis\/"},{"title":"Biopharma","link":"\/applications\/life-science\/biopharma\/"},{"title":"Advanced Tissue Imaging & Analysis","link":"\/applications\/life-science\/advanced-tissue-imaging-analysis\/"}]},{"id":"cs62332","title":"Mica","subtitle":"Mica - The world\u2019s first Microhub. Everything you need to enable discoveries, unified in one easy-to-use system. Simultaneous 4-color widefield, confocal resolution, AI supported analysis.","abstract":"\u003Cp\u003EThe \u003Cstrong\u003Eworld\u2019s first Microhub\u003C\/strong\u003E. More than a highly automated microscope, Mica unites \u003Cstrong\u003Ewidefield and confocal\u003C\/strong\u003E imaging in a \u003Cstrong\u003Esample protecting, incubating environment\u003C\/strong\u003E. With the simple push of a button, you have everything you need - all in one place - to supercharge fluorescence imaging workflows and get meaningful scientific results faster.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/confocal-microscopes\/p\/mica\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/user_upload\/Mica-Microhub-reddot-winner-2023-.jpg\n ","squareImage":0,"applications":[{"title":"Cell Biology","link":"\/applications\/life-science\/cell-biology\/"},{"title":"Cellular Analysis","link":"\/applications\/life-science\/cellular-analysis\/"},{"title":"Biopharma","link":"\/applications\/life-science\/biopharma\/"},{"title":"Advanced Tissue Imaging & Analysis","link":"\/applications\/life-science\/advanced-tissue-imaging-analysis\/"}]},{"id":"cs63053","title":"STELLARIS Cryo","subtitle":"STELLARIS Cryo is a confocal light microscope system that helps you to target your area of interest for cryo-electron tomography (CryoET)","abstract":"\u003Cp\u003ESTELLARIS Cryo is a confocal microscope system that helps you to target your area of interest for cryo-electron tomography (CryoET). The STELLARIS Cryo gives you the precision to target reliably, while offering superior performance you can count on and sample safety for your experiments.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/confocal-microscopes\/p\/stellaris-cryo\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/c\/2\/csm_Stellaris_Cryo-Confocal-List_73a28fcee8.jpg\n ","squareImage":0,"applications":[{"title":"Correlative Light and Electron Microscopy (CLEM)","link":"\/applications\/life-science\/correlative-light-and-electron-microscopy-clem\/"}]},{"id":"cs53749","title":"THUNDER Imager Tissue","subtitle":"The THUNDER Imager Tissue allows real-time fluorescence imaging of 3D tissue sections typically used in neuroscience and histology research. ","abstract":"\u003Cp\u003EThe THUNDER Imager Tissue allows real-time fluorescence imaging of 3D tissue sections typically used in neuroscience and histology research. Acquire rich, detailed images of thick tissues, free from the haze ofout-of-focus blur.\u003C\/p\u003E\r\n\u003Cp\u003EWith Computational Clearing, an innovative Leica technology, fine structures deep in tissues can be resolved thanks to Computational Clearing, an innovative Leica technology. Image detailed morphological structures like axons and dendrites of neurons in a brain slice. The high image quality, even with thick tissue sections, is combined with the well-known speed, fluorescence efficiency, and ease of use of a widefield microscope.\u003C\/p\u003E\r\n\u003Cp\u003EGain these advantages using a THUNDER Imager Tissue for your research:\u003C\/p\u003E\r\n\u003Cul\u003E\u003Cli\u003EGet computationally cleared images directly in your live preview with THUNDER Live\u003C\/li\u003E\u003Cli\u003ERapidly acquire blur-free images showing finest details of the morphology, even deep within thick specimens\u003C\/li\u003E\u003Cli\u003EFast sample overviews with full electronic synchronization of the hardware\u003C\/li\u003E\u003Cli\u003EImage and analyze challenging tissue sections with an intuitive and integrated workflow\u003C\/li\u003E\u003C\/ul\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/thunder-imaging-systems\/p\/thunder-imager-tissue\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/d\/6\/csm_THUNDER-Imager-Tissue_neurons_list_01_86647f46cd.jpg\n ","squareImage":0,"applications":[{"title":"Advanced Tissue Imaging & Analysis","link":"\/applications\/life-science\/advanced-tissue-imaging-analysis\/"}]},{"id":"cs47286","title":"Leica LMD Systems","subtitle":"Laser Microdissection enables users to isolate specific single cells or entire areas of tissue.","abstract":"\u003Cp\u003ELaser Microdissection (LMD, also known as Laser Capture Microdissection or LCM) enables users to isolate specific single cells or entire areas of tissue. Leica LMD systems allow users to easily isolate Regions of Interest (ROI) from entire areas of tissue down to single cells or even subcellular structures such as chromosomes.\u003C\/p\u003E\r\n\u003Cp\u003ELMD is typically used in genomics (DNA), transcriptomics (mRNA, miRNA), proteomics, metabolomics, and even next generation sequencing (NGS). Researchers in neurology, cancer research, plant analysis, forensics or climate research rely on this method. LMD is a perfect tool for live cell culture (LCC), for cloning and re-cultivation, manipulation or downstream analysis.\u003C\/p\u003E","link":"\n https:\/\/www.leica-microsystems.com\/products\/light-microscopes\/p\/leica-lmd7\/\n ","linkLabel":"Read More","theme":"\n light\n ","image":"\n \/fileadmin\/_processed_\/9\/8\/csm_Leica-LMD7-LaserMicrodissection-list_6413136407.jpg\n ","squareImage":0,"applications":[{"title":"Biopharma","link":"\/applications\/life-science\/biopharma\/"},{"title":"Forensic Science Microscopes","link":"\/applications\/forensic-science\/"},{"title":"Advanced Tissue Imaging & Analysis","link":"\/applications\/life-science\/advanced-tissue-imaging-analysis\/"}]},{"id":"cs162","title":"FS M","subtitle":"Manual Forensic Comparison Macroscope","abstract":"\u003Cp\u003EThe Leica FS M manually-controlled forensic macroscope provides the flexibility, convenience, and comfort that make it the universal instrument of a \u003Cstrong\u003Efirearms\u003C\/strong\u003E and \u003Cstrong\u003Etoolmark examiner\u003C\/strong\u003E. \u003C\/p\u003E\r\n\u003Cp\u003EThe versatile system is ideal for the \u003Cstrong\u003Esimultaneous observation\u003C\/strong\u003E of evidence for training and consultation. The \u003Cstrong\u003Ehigh-quality comparison bridge\u003C\/strong\u003E supports two precisely matched sets of apochromatically corrected objectives on quintuple ball-bearing nosepieces.\u003C\/p\u003E\r\n\u003Cp\u003EA 22mm field of view produces erect, unreversed images. 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Meet Mica
The world’s first Microhub

Mica enables microscopy access for all, removes the constraints of traditional four-color fluorescence imaging and radically simplifies workflows.

DM4 B & DM6 B

Enhance your life-science and clinical research with the DM4 B and DM6 B upright microscopes. With flexible software solutions, they allow you to focus on experiments while reducing manual work.

M50, M60 & M80

Routine stereo microscopes

Ivesta 3

Greenough Stereo Microscopes. Optimize visual inspection and rework while achieving reliable, consistent results.

Product archive

Image of C2C12 cells: The cells are stained with lamin B (magenta) which indicates nuclear structure, Hoechst (blue) indicating DNA, and γH2AX (yellow) indicating damage to DNA. Cells were imaged using a THUNDER Imager 3D Live Cell with a 63X/1.4 oil immersion objective.

Cell Biology Research

Imaging solutions offered by Leica Microsystems are designed to maximize your cell biology research.

Cell Biology Solutions

Frequently Asked Questions Light Microscopes

What type of accessories does my light microscope come with? What will I need to purchase separately?

Leica microscopes are modular and shipped in the configuration that best fits your stated needs or application. In case your needs change later, you can always upgrade your workstation by adding available accessories.

Do you have multiple users utilizing a single microscope? Which Leica light microscope solution allows the setup of individual user preferences?

Leica Microsystems offers the free Store & Recall software (available with the LAS X software platform for industry) which allows you to customize the microscope functions, adapting them to the requirements and needs of each individual user. The software also allows you to restore all system settings saved with the acquired image.

Calibrated and comparable images are a must. Which types of light microscope would you recommend for this need?

All our encoded microscope solutions offer calibration and image comparison. Furthermore, Leica Microsystems offers the free Store & Recall software which allows you to restore all system settings saved with the acquired image.

Do I need a computer to operate a Leica compound light microscope?

No, you don’t. By installing a FLEXACAM C1 camera, you can directly save the images on an IT network server or USB medium. You can also send the images via e-mail over your network without the need for a PC.

I need to quickly document and share results with team members. What is the best solution you can recommend?

With the FLEXACAM C1 camera you can directly save images on an IT network server or USB medium. You can also send the images via e-mail without having to use a computer.

What kinds of modular accessories are available to extend the range of use of my microscope?

There are a lot of accessories. Please get in contact with your local Leica sales representative.

How are ergonomic accessories designed to reduce repetitive strain injuries during long working hours?

There are a lot of ergonomic accessories for Leica light microscopes. Please contact your local Leica sales representative for more details or visit: Ergonomic Accessories for Stereo Microscopes

Is the Leica Application Suite (LAS) X software both Windows and MAC compatible? How about Linux?

LAS X software only runs with Windows, but for a MAC we have a dedicated software called ‎Leica Acquire that you could download for free from the Apple store: https://apps.apple.com/it/app/leica-acquire/id733706983?mt=12
However, there is no software for Linux.

Are Leica microscopes only compatible with the Leica Application Suite software? Is integration with a 3rd party software possible?

Yes, use of a 3rd party software is possible: https://www.splashtop.com/classroom

Other than Leica cameras, can I mount 3rd party SLR/DSLR cameras to a Leica microscope or macroscope for that matter?

We have adapters for all C-mount compatible cameras.

Are there any mobile solutions for learning and sharing? Android or iOS?

The free AirLab software, compatible with iOS or ANDROID, allows the user to immediately share images, videos, and comments.

What is a compound light microscope?

A compound microscope uses optics to produce a magnified image of a sample so that with details of it can be observed that are undetectable with the naked eye. The most basic optics of a compound microscope has at least 2 lenses: i) an objective placed nearby the sample which creates a magnified, real image of it and ii) eyepieces or oculars which are used to view the real image of the sample. A human who looks through the eyepieces sees the sample as a virtual image on his/her retina. For more information, please refer to the Science Lab article: Optical Microscopes – Some Basics

What is the maximum magnification of a compound light microscope?

The maximum useful magnification value achieved with any type of light microscope depends on its ultimate resolving power or maximal resolution. The resolution depends on the microscope objective lens numerical aperture (NA). At low magnification values, the NA is small leading to a low resolution. At high magnification values, the NA is high yielding a high resolution. However, because the NA has a finite maximum value, approximately 1.3, the “useful” range of magnification is limited to about 1,800x for conventional light microscopes. Magnification beyond the useful range, which can occur whenever digital microscope cameras display images on large monitors, is called "empty” magnification. In this non-useful magnification range, the sample structures appear larger, but no additional details are resolved. For more information, please refer to the Science Lab articles: Beware of "Empty" Magnification, What Does 30,000:1 Magnification Really Mean?

Semiconductor Inspection

Light microscope solutions help suppliers and device manufacturers achieve fast and precise inspection and analysis for semiconductor wafer processing. Conformity to the defined specifications during semiconductor device manufacturing is critical for reliability.

Materials Science

Excellent sample preparation and imaging methods are key for visualizing the fine details of materials with reliability and accuracy. Leica light microscope solutions enable you to achieve this goal with high-quality optics and intelligent automation for optimal workflows and analysis.