Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Latest Articles

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Correlative In-Resin Super-Resolution and Electron Microscopy Using Standard Fluorescent Proteins

We introduce a method for correlative in-resin super-resolution fluorescence and electron microscopy (EM) of biological structures in mammalian…

Jun 04, 2015

Abstract
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Electron Tomography of Cryo-Immobilized Plant Tissue: A Novel Approach to Studying 3D Macromolecular Architecture of Mature Plant Cell Walls In Situ

Cost-effective production of lignocellulosic biofuel requires efficient breakdown of cell walls present in plant biomass to retrieve the wall…

Nov 17, 2014

Abstract
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Capturing Cellular Dynamics with Millisecond Temporal Resolution

The combination of two powerful techniques: optogenetics and high-pressure freezing now makes it possible to visualize a dynamic cellular activity…

May 12, 2014

Story
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Freeze Substitution of Trypanosoma brucei

Chemical fixation of biological specimens for ultrastructural investigation is a relatively slow and selective process, and therefore a common source…

Mar 18, 2014

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Brief Introduction to Freeze Substitution

Freeze-substitution is a process of dehydration, performed at temperatures low enough to avoid the formation of ice crystals and to circumvent the…

Feb 04, 2014

Tutorial
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From Dynamic Live Cell Imaging to 3D Ultrastructure

To correlate dynamic events in adherent cells with both ultrastructural and 3D information, we developed a method for cultured cells that combines…

Aug 28, 2013

Abstract