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Multicellular Organization during Stem Cell Dynamics
Multicellular organization, e.g. during tissue morphogenesis or of human embryonic stem cells, relies on collective cytoskeletal dynamics. During…
Feb 21, 2022Abstract - Loading...
Phosphoprotein Regulates Integrin Endosomal Trafficking
Integrins are involved in cell-cell and cell-extracellular matrix adhesion. In addition, they mediate several signaling pathways, regulating e.g. cell…
Feb 21, 2022Abstract - Loading...
Studying Actin Cytoskeleton and Microfilament Assembly
This article demonstrates how actin microfilament assemblies can be clearly visualized with superior resolution at the plasma membrane of a cell using…
Jun 24, 2021Case Study - Loading...
Plant Cell Development and Morphogenesis
The article discusses how tubulin molecules, which make up microtubules, in plant cells can be studied with total internal reflection fluorescence…
Jan 28, 2021Case Study - Loading...
Where to go? Cellular Migration requires coordinated Transitions of Actin Cortex
Plants, Bacteria, and Fungi possess a rigid cell wall that protects the cell and gives it shape. Animal cells, such as mammalian cells, have no outer…
Aug 19, 2019Story - Loading...
Initiation of Lamellipodia and Ruffles Involves Cooperation Between mDia1 and the Arp2/3 Complex
Protrusion of lamellipodia and ruffles requires polymerization of branched actin filaments by the Arp2/3 complex. Although regulation of Arp2/3…
Oct 24, 2016Abstract - Loading...
Botulinum Neurotoxin Type-A Enters a Non-Recycling Pool of Synaptic Vesicles
Neuronal communication relies on synaptic vesicles undergoing regulated exocytosis and recycling for multiple rounds of fusion. Whether all synaptic…
Oct 19, 2016Abstract - Loading...
Video Talk by Daniel Axelrod: Total Internal Reflection Fluorescence (TIRF) Microscopy
Total Internal Reflection Fluorescence (TIRF) Microscopy is a technique that only illuminates dye molecules near a surface. In this video, the pioneer…
Mar 09, 2015Tutorial - Loading...
Controlling the TIRF Penetration Depth is Mandatory for Reproducible Results
The main feature of total internal reflection fluorescence (TIRF) microscopy is the employment of an evanescent wave for the excitation of…
Apr 24, 2012Tutorial - Loading...
Total Internal Reflection Fluorescence (TIRF) Microscopy
Total internal reflection fluorescence (TIRF) is a special technique in fluorescence microscopy developed by Daniel Axelrod at the University of…
Mar 11, 2012Tutorial - Loading...
TIRF Microscopy Explores Cellular Transport Processes
Due to their special role in organ function and the exchange of biological components some body cells developed certain polarization characteristics.…
Mar 11, 2012Story - Loading...
TIRF Microscopy of the Apical Membrane of Polarized Epithelial Cells
Application of TIRF microscopy (Total Internal Reflection Fluorescence) allows the visualization of structures at the apical surface of polarized…
Apr 12, 2011Story - Loading...
Exploring Cell Logistics
Using TIRF microscopy, scientists have been able to take a closer look at intracellular transport processes with the example of the galactose-binding…
Nov 02, 2007Story