Science Lab

Science Lab

Science Lab

Learn. Share. Contribute. The knowledge portal of Leica Microsystems. Find scientific research and teaching material on the subject of microscopy. The portal supports beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies. Become part of the Science Lab community and share your expertise.
Dr. Nordmann in conversation with Dr. Falk Schlaudraff, Manager Product Management Uprights (widefield/compound) at Leica Microsystems

How a Breakthrough in Spatial Proteomics Saved Lives

Toxic epidermal necrolysis (TEN) is a rare but devastating reaction to common medications like antibiotics or gout treatments. It begins innocuously, often as a rash, but can escalate rapidly into…

A Novel Laser-Based Method for Studying Optic Nerve Regeneration

Optic nerve regeneration is a major challenge in neurobiology due to the limited self-repair capacity of the mammalian central nervous system (CNS) and the inconsistency of traditional injury models.…
Fluorescence microscopy of sectioned tissue, showing the interface between the extensor digitorum longus muscle and the common peroneal nerve in the adult rat. Regenerative peripheral nerve interface (RPNI) at 2 weeks. Image acquired using Mica. Stained for nuclei (blue), neurofilaments (green) and S100B (red). Image courtesy of Dr. Aaron Lee, Department of Bioengineering (Lab of Dr. Rylie Green), Imperial College London.

How to Image Axon Regeneration in Deep Muscle Tissue

This study highlights Dr. Aaron Lee’s research on mapping nerve regeneration in muscle grafts post-amputation. Limb loss often leads to reduced quality of life, not only from tissue loss but also due…
A fruit fly (Drosophila melanogaster) observed with an Ivesta 3 stereo microscope during fly pushing (sorting of the flies). The scale bar length is 1 mm. Image courtesy of M. Benton, EMBL, Heidelberg, Germany.

A Guide to Using Microscopy for Drosophila (Fruit Fly) Research

The fruit fly, typically Drosophila melanogaster, has been used as a model organism for over a century. One reason is that many disease-related genes are shared between Drosophila and humans. It is…
Mouse brain slice which was immunostained with GFAP-A647 and imaged using a THUNDER Imager Tissue. Courtesy of H. Xu, University of Pennsylvania, Philadelphia, USA.

A Guide to Neuroscience Research

Neuroscience often requires investigating challenging specimens to better understand the nervous system and disorders. Leica microscopes helps neuroscientists obtain insights into neuronal functions.
Zebrafish-embryo image captured using a THUNDER Imager Tissue and live instant computational clearing.

Improving Zebrafish-Embryo Screening with Fast, High-Contrast Imaging

Discover from this article how screening of transgenic zebrafish embryos is boosted with high-speed, high-contrast imaging using the DM6 B microscope, ensuring accurate targeting for developmental…
Image: Human stem cell-derived mid brain organoids. Courtesy of Dr Tanya Singh, University of Oxford.

Unlocking the Secrets of Organoid Models in Biomedical Research

Get ready to delve deeper into the world of organoids and 3D models, which are essential tools for advancing our understanding of human health. Navigating these complex structures and obtaining clear…
Spherulitic crystals of hippuric acid, which were imaged with a Leica microscope using crossed polarizers, showing so-called Maltese crosses.

A Guide to Polarized Light Microscopy

Polarized light microscopy (POL) enhances contrast in birefringent materials and is used in geology, biology, and materials science to study minerals, crystals, fibers, and plant cell walls.
Area of a printed circuit board (PCB) which was imaged with extended depth of field (EDOF) using digital microscopy.

Depth of Field in Microscope Images

For microscopy imaging, depth of field is an important parameter when needing sharp images of sample areas with structures having significant changes in depth. In practice, depth of field is…
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