Science Lab

Science Lab

Science Lab

Learn. Share. Contribute. The knowledge portal of Leica Microsystems. Find scientific research and teaching material on the subject of microscopy. The portal supports beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies. Become part of the Science Lab community and share your expertise.
67-hour, multi-position time-lapse of mouse intestinal organoids expressing the cell cycle reporter FUCCI2 (hGem-mVenus and hCdt1-mCherry).

Focus on Long-Term Imaging in 3D with Light Sheet Microscopy

Long-term 3D imaging reveals how complex multicellular systems grow and develop and how cells move and interact over time, unlocking critical insights into development, disease, and regeneration.…
Image of roundworm C. elegans acquired with a M205 FA fluorescence automated stereo microscope in combination with Rottermann contrast. Areas labelled with mCherry are seen as reddish purple.

A Guide to C. elegans Research – Working with Nematodes

Efficient microscopy techniques for C. elegans research are outlined in this guide. As a widely used model organism with about 70% gene homology to humans, the nematode Caenorhabditis elegans (also…

A Novel Laser-Based Method for Studying Optic Nerve Regeneration

Optic nerve regeneration is a major challenge in neurobiology due to the limited self-repair capacity of the mammalian central nervous system (CNS) and the inconsistency of traditional injury models.…
Fluorescence microscopy of sectioned tissue, showing the interface between the extensor digitorum longus muscle and the common peroneal nerve in the adult rat. Regenerative peripheral nerve interface (RPNI) at 2 weeks. Image acquired using Mica. Stained for nuclei (blue), neurofilaments (green) and S100B (red). Image courtesy of Dr. Aaron Lee, Department of Bioengineering (Lab of Dr. Rylie Green), Imperial College London.

How to Image Axon Regeneration in Deep Muscle Tissue

This study highlights Dr. Aaron Lee’s research on mapping nerve regeneration in muscle grafts post-amputation. Limb loss often leads to reduced quality of life, not only from tissue loss but also due…
5 hour time-lapse maximum intensity projection of a zebrafish embryo along the z-axis at 3 days post fertilization. Left: microglia cells. Right: bright field channel. Courtesy of Prof. Francesca Peri, University of Zurich, Switzerland.

Capturing Developmental Dynamics in 3D

This application note showcases how the Viventis Deep dual-view light sheet microscope was successfully used by researchers for exploring high-resolution, long-term imaging of 3D multicellular models…
A fruit fly (Drosophila melanogaster) observed with an Ivesta 3 stereo microscope during fly pushing (sorting of the flies). The scale bar length is 1 mm. Image courtesy of M. Benton, EMBL, Heidelberg, Germany.

A Guide to Using Microscopy for Drosophila (Fruit Fly) Research

The fruit fly, typically Drosophila melanogaster, has been used as a model organism for over a century. One reason is that many disease-related genes are shared between Drosophila and humans. It is…

A Guide to Zebrafish Research

To obtain optimal results while doing zebrafish research, especially during screening, sorting, handling, and imaging, seeing the fine details and structures is important. They help researchers make…
Zebrafish-embryo image captured using a THUNDER Imager Tissue and live instant computational clearing.

Improving Zebrafish-Embryo Screening with Fast, High-Contrast Imaging

Discover from this article how screening of transgenic zebrafish embryos is boosted with high-speed, high-contrast imaging using the DM6 B microscope, ensuring accurate targeting for developmental…
UC Enuity Ultramicrotome Person at Work

Essential Guide to Ultramicrotomy

When studying samples, to visualize their fine structure with nanometer scale resolution, most often electron microscopy is used. There are 2 types: scanning electron microscopy (SEM) which images the…
Beckman Coulter LinkBeckman Coulter LogoGenedata LinkIDBS LogoIDBS LinkIDBS LogoAbcam Limited LinkAbcam Limited LogoMolecular Devices LinkMolecular Devices LogoPhenomenex LinkPhenomenex LogoSciex LinkSciex LogoAldevron LinkAldevron LogoIDT LinkIDT Logo
Scroll to top