Science Lab

Learn. Share. Contribute. The knowledge portal of Leica Microsystems. Find scientific research and teaching material on the subject of microscopy. The portal supports beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies. Become part of the Science Lab community and share your expertise.

Accelerating Discovery for Multiplexed Imaging of Diverse Tissues

Explore IBEX: Open-source multiplexed imaging. Join the collaborative IBEX Imaging Community for optimized tissue processing, antibody selection, and human atlas construction.

Particulate contamination in between moving metal plates.

Key Factors for Efficient Cleanliness Analysis

An overview of the key factors necessary for technical cleanliness and efficient cleanliness analysis concerning automotive and electronics manufacturing and production is provided in this article.

Microscope equipped with a K7 color CMOS camera for life-science and industry imaging applications.

Technical Terms for Digital Microscope Cameras and Image Analysis

Learn more about the basic principles behind digital microscope camera technologies, how digital cameras work, and take advantage of a reference list of technical terms from this article.

Images of the same area of a processed wafer taken with standard (left) and oblique (right) brightfield illumination using a Leica compound microscope. The defect on the wafer surface is clearly more visible with oblique illumination.

Rapid Semiconductor Inspection with Microscope Contrast Methods

Semiconductor inspection during the production of patterned wafers and ICs (integrated circuits) is important for identifying and minimizing defects. To increase the efficiency of quality control in…

2D slice of colon cancer tissue stained with 30 markers and imaged using the Cell DIVE system. Analysis performed using Aivia 13’s new multiplex cell detection recipe and automatic clustering tool. Each phenotype denoted in a different color.

Transforming Multiplexed 2D Data into Spatial Insights Guided by AI

Aivia 13 handles large 2D images and enables researchers to obtain deep insights into microenvironment surrounding their phenotypes with millions of detected objects and automatic clustering up to 30…

Applying dispersive viscoelastic to coat the anterior chamber. Image courtesy of Arsham Sheybani, MD, Washington University School of Medicine.

Dislocated Cataract Angle Closure Aided by Intraoperative OCT

Learn how a dislocated cataract was treated with angle closure assisted by intraoperative OCT to achieve long-term good results without future lens dislocation.

Spheroid stained with Cyan: Dapi nuclear countertain; Green AF488 Involucrin; Orange AF55 Phalloidin Actin; Magenta AF647 CK14.

Notable AI-based Solutions for Phenotypic Drug Screening

Learn about notable optical microscope solutions for phenotypic drug screening using 3D-cell culture, both planning and execution, from this free, on-demand webinar.

Hepatocellular Carcinoma with 13 biomarkers shown – Beta-Catenin, CD3D, CD4, CD8a, CD31, CD44, CD163, DAPI, PanCK, PCK26, PD1, SMA, and Vimentin.

Understanding Tumor Heterogeneity with Protein Marker Imaging

Explore tumor heterogeneity and immune cell dynamics. See how quantitative imaging analysis reveals spatial relationships and molecular insights crucial for advancing cancer research and therapeutics.

Adult human Alzheimer’s brain demonstrating a panel of 15 markers.

The Shape of the Brain: Spatial Biology of Alzheimer’s Disease

Uncover cell identity and brain structure in Alzheimer's disease with Cell DIVE multiplexed imaging, demonstrating how spatial biology can lead to advances in therapy development for…