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Science Lab

Science Lab

Learn. Share. Contribute. The knowledge portal of Leica Microsystems. Find scientific research and teaching material on the subject of microscopy. The portal supports beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies. Become part of the Science Lab community and share your expertise.
Blood vessel system of a zebrafish larvae

Overcoming Challenges with Microscopy when Imaging Moving Zebrafish Larvae

Zebrafish is a valuable model organism with many beneficial traits. However, imaging a full organism poses challenges as it is not stationary. Here, this case study shows how zebrafish larvae can be…

A Guide to Neuroscience Research

Are you working towards a better understanding of neurodegenerative diseases or studying the function of the nervous system? See how you can make breakthroughs with imaging solutions from Leica…
Cell DIVE multiplexed image of FFPE tissue section from syngeneic murine cancer model, 4T1.

Mapping Tumor Immune Landscape with AI-Powered Spatial Proteomics

Spatial mapping of untreated tumors provides an overview of the tumor immune architecture, useful for understanding therapeutic responses. Immunocompetent murine models are essential for identifying…

A Guide to Zebrafish Research

For the best result during screening, sorting, manipulation, and imaging you need to see details and structures to make the right decisions for your next steps in research. Known for outstanding…

A Guide to OCT

Leica Optical Coherence Tomography (OCT) systems support ophthalmologists, ophthalmic surgeons, and researchers with easy-to-use, high-quality imaging technology.
GLOW800 Augmented Reality Fluorescence used for real-time blood flow visualization in aneurysm clipping surgery

Aneurysm Clipping: Assessing Perforators in Real-Time with AR Fluorescence

This article covers two aneurysm clipping cases highlighting the clinical benefits of GLOW800 Augmented Reality Fluorescence application in neurosurgery, based on insights from Prof. Tohru Mizutani,…
Prof. Fontana uses the Proveo 8 with EnFocus intraoperative OCT for his corneal surgery.

How does Real-Time OCT Imaging Impact Precision in Corneal Surgery?

Corneal surgery is a highly specialized field. It requires great surgical precision to overcome challenges such as visualizing clearly the full anterior chamber, performing Descemet membrane peeling…
GLOW400 AR Fluorescence in anatomy view, image courtesy of Prof. Kondo

How to Achieve Brain Tissue Resection with GLOW400 AR

Intraoperative MRI is one form of real-time intraoperative visualization, but if more in-depth visualization to identify a tumor during surgery is wanted, intraoperative fluorescence diagnostics is…
Block-face created by automatic trimming under fluorescence. Mammalian cells of interest, stained with CellTrackerTM Green are visualized within the block-face using the UC Enuity equipped with the stereo microscope M205 FA. In the background a carbon finder grid in black is visible. All samples in the article are created by Felix Gaedke, PhD, CECAD, Cologne, Germany.

How to Automatically Obtain Fluorescent Cells of Interest in a Block-face

Block-face created by automatic trimming under fluorescence. Mammalian cells of interest, stained with CellTrackerTM Green are visualized within the block-face using the UC Enuity equipped with the…
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