Science Lab

Learn. Share. Contribute. The knowledge portal of Leica Microsystems. Find scientific research and teaching material on the subject of microscopy. The portal supports beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies. Become part of the Science Lab community and share your expertise.

Structural details of the C. elegans, head in cross-section. Courtesy of Müller-Reichert T, MPI-CBG, Dresden, Germany, and McDonald K, University of California, Berkeley, USA.

Brief Introduction to High-Pressure Freezing

Water is the most abundant cellular constituent and therefore important for preserving cellular ultra-structure. Currently the only way to fix cellular constituents without introducing significant…

Scheme of a 2D mosaic scan. Drosophila melanogaster (eye section)

Mosaic Images

Confocal laser scanning microscopes are widely used to create highly resolved 3D images of cells, subcellular structures and even single molecules. Still, an increasing number of scientists are…