Science Lab

Learn. Share. Contribute. The knowledge portal of Leica Microsystems. Find scientific research and teaching material on the subject of microscopy. The portal supports beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies. Become part of the Science Lab community and share your expertise.

Intraoperative OCT-Assisted Surgical Management of Proliferative Vitreoretinopathy

Proliferative vitreoretinopathy (PVR) is a plague to patients and their surgeons after recent rhegmatogenous retinal detachment (RD). Despite excellent initial surgical outcomes, it is the most common…

Fast, High-quality Vitrification with the EM ICE High Pressure Freezer

The EM ICE High Pressure Freezer was developed with a unique freezing principle and uses only a single pressurization and cooling liquid: liquified nitrogen (LN2). This design enables three major…

Cryo FIB lamella - Overlay of SEM and confocal fluorescence image. Target structure in yeast cells (nuclear pore proteine Nup159-Atg8-split Venus, red) marked by an arrow. Scale bar: 5 µm. Alegretti et al., Nature 586, 796-800 (2020).

Targeting Active Recycling Nuclear Pore Complexes using Cryo Confocal Microscopy

In this article, how cryo light microscopy and, in particular cryo confocal microscopy, is used to improve the reliability of cryo EM workflows is described. The quality of the EM grids and samples is…

Advanced Visualization in ENT Surgery

ENT surgery poses unique challenges. It requires excellent visualization, both in terms of magnification and illumination. As such, choosing the right operating microscope is critical.

Advanced Visualization in Spine Surgery

There have been meaningful advances in spine surgery in recent years. Minimally Invasive Spine Surgery (MISS) techniques provide significant benefits, helping to minimize surgical trauma, improve…

How Augmented Reality is Transforming Vascular Neurosurgery

Augmented Reality is changing surgery, with new information helping to improve the precision and safety of procedures. This is especially true in vascular neurosurgery where Augmented Reality is…

Overcoming Ophthalmologic Surgery Challenges

Ophthalmology surgical procedures involving both the anterior and posterior segment can be particularly challenging. Good visualization is required to operate with precision and confidence. Prof.…

Advanced Visualization in Maxillofacial Plastic and Reconstructive Surgery

Plastic and Reconstructive Surgery is very demanding. Surgical microscopes play an important role, helping to ensure flaps are well vascularized. Dr. Christine Bach is a Plastic and Reconstructive…

Moving to Routine Use of Intraoperative OCT in Eye Surgery

Dr Barbara Parolini is one of the pioneers in the use of intraoperative OCT in eye surgery. Since 2016, she has gained a lot of clinical experience with different intraoperative OCT systems. In this…