Science Lab

Learn. Share. Contribute. The knowledge portal of Leica Microsystems. Find scientific research and teaching material on the subject of microscopy. The portal supports beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies. Become part of the Science Lab community and share your expertise.

Image: Adult rat brain. Neurons (Alexa Fluor488, green), Astrocytes (GFAP, red), Nuclei (DAPI, blue). Image courtesy of Prof. En Xu, Institute of Neurosciences and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, China.

Multicolor Microscopy: The Importance of Multiplexing

The term multiplexing refers to the use of multiple fluorescent dyes to examine various elements within a sample. Multiplexing allows related components and processes to be observed in parallel,…

Considerations for Multiplex Live Cell Imaging

Simultaneous multicolor imaging for successful experiments: Live-cell imaging experiments are key to understand dynamic processes. They allow us to visually record cells in their living state, without…

A New Method for Convenient and Efficient Multicolor Imaging

The technique combining hyperspectral unmixing and phasor analysis was developed to simplify the process of getting images from a sample labeled with multiple fluorophores. This aggregate method…

3D-volume-rendered light-sheet microscope image of a spheroid showing depth coding in different colors.

Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS

Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…

Single timepoint of a time-lapse recording of mammary epithelial micro spheroid cultured in 3D highlighting individual mitotic events

Observing Complex Cellular Interactions at Multiple Scales

Learn how to observe challenging cellular interactions with easy to deploy object detection and relationship measurements.

How to Boost your Microelectronic Component Inspection Performance

Do you need to see more when inspecting silicon wafers or MEMS? Would you like to get sharp and detailed sample images which are similar to those from electron microscopes? Watch this free webinar…

How Industrial Applications Benefit from Fluorescence Microscopy

See what you can do with fluorescence microscopy for industrial and materials science applications from this webinar. Fluorescence is well known for biological applications, however, almost all…

How to Select a Microscope for Cataract Surgery

What to consider in the selection of an ophthalmic microscope for cataract procedures. Bearing these aspects in mind will equip surgeons well for talks with manufacturer representatives. Many…

Intravital Microscopy of Cancer

Join our guest speaker Prof Dr Jacco van Rheenen, as he presents his work on the identity, behavior and fate of cells that drive the initiation and progression of cancer.