
Science Lab
Science Lab
Learn. Share. Contribute. The knowledge portal of Leica Microsystems. Find scientific research and teaching material on the subject of microscopy. The portal supports beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies. Become part of the Science Lab community and share your expertise.
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How to Image Axon Regeneration in Deep Muscle Tissue
This study highlights Dr. Aaron Lee’s research on mapping nerve regeneration in muscle grafts post-amputation. Limb loss often leads to reduced quality of life, not only from tissue loss but also due…
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Capturing Developmental Dynamics in 3D
This application note showcases how the Viventis Deep dual-view light sheet microscope was successfully used by researchers for exploring high-resolution, long-term imaging of 3D multicellular models…
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A Guide to Using Microscopy for Drosophila (Fruit Fly) Research
The fruit fly, typically Drosophila melanogaster, has been used as a model organism for over a century. One reason is that many disease-related genes are shared between Drosophila and humans. It is…
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Development and Derisking of CRISPR Therapies for Rare Diseases
This on-demand presentation by Dr. Fyodor Urnov and Dr. Sadik Kassim, originally delivered at ASGCT 2025, focused on a critical challenge in genetic medicine: how to scale CRISPR therapies from…
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Integrated Serial Sectioning and Cryo-EM Workflows for 3D Biological Imaging
This on-demand webinar explores how integrated tools can support electron microscopy workflows from sample preparation to image analysis. Experts Andreia Pinto, Adrian Boey, and Hoyin Lai present the…
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Multiplexed Imaging Reveals Tumor Immune Landscape in Colon Cancer
Cancer immunotherapy benefits few due to resistance and relapse, and combinatorial therapeutic strategies that target multiple steps of the cancer-immunity cycle may improve outcomes. This study shows…
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AI-Powered Hi-Plex Spatial Analysis Tools for Breast Cancer Research
Breast cancer (BC) is the leading cause of cancer-related deaths in women. Investigating the tumor microenvironment (TME) is crucial to elucidate the mechanisms of tumor progression. Systematic…
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A Guide to Neuroscience Research
Neuroscience often requires investigating challenging specimens to better understand the nervous system and disorders. Leica microscopes helps neuroscientists obtain insights into neuronal functions.
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The “Waffle Method”: High-Pressure Freeze Complex Samples
This article describes the advantages of a special high pressure freezing method, the so-called “Waffle Method”. Learn how the “Waffle Method” uses EM grids as spacers for high-pressure freezing,…