Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Confocal imaging of a SARS-CoV-2-infected epithelia at 4 dpi (orthogonal sections)

STELLARIS Contributes to Understanding COVID-19 Infection

What are the structural and functional consequences of a SARS-CoV-2 infection? To answer this important question, the authors used 3D cultures that mimic an airway epithelium and used different…

Coronavirus Replication in Host Cells

In this study, a molecular pore complex, which spans both membranes of SARS-CoV-2/COVID-19 virus-induced cytosolic vesicles and likely plays a role in replication, was visualized.

Image courtesy of Dr. Stefan Finke, Friedrich-Loeffler- Institute, Riems, Germany.

How Can Immunofluorescence Aid Virology Research?

Modern virology research has become as crucial now as ever before due to the global COVID-19 pandemic. There are many powerful technologies and assays that virologists can apply to their research into…

Upright Fluorescence Microscopy for Virus Replication Studies

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread over the world quickly. Due to its dramatic impact, researchers are interested in the nature of the…

Microscopy in Virology

The coronavirus SARS-CoV-2, causing the Covid-19 disease effects our world in all aspects. Research to find immunization and treatment methods, in other words to fight this virus, gained highest…

Observing the effect on transcription factor signaling and chromatin landscapes in cells infected with the human coronavirus 229E

Viral infection triggers an inflammatory cellular response which is characterized by altered gene expression. In this study, the influence of coronaviruses on cellular NF-κB (transcription factor)…

Covid-19: Mitigating Risks in Dentistry

The coronavirus pandemic poses significant challenges for dental professions. Learn how microscopes can help increase physical distance and minimize risks.

How to Sanitize a Microscope

Due to the current coronavirus pandemic, there are a lot of questions regarding decontamination methods of microscopes for safe usage. This informative article summarizes general decontamination…