Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Latest Articles

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Formulated Product Characterization with SRS Microscopy
Creams, pastes, gels, emulsions, and tablets are ubiquitous across a wide range of manufacturing sectors from pharmaceuticals and consumer health…
Oct 25, 2021
Case Study
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Coherent Raman Scattering Microscopy Publication List
CRS (Coherent Raman Scattering) microscopy is an umbrella term for label-free methods that image biological structures by exploiting the…
Jun 24, 2021
Story
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How to Quantify Label-free Blood Flow
The application note “Label-free Blood Flow Quantification” is a guide for data acquisition and analysis of blood flow using label-free third harmonic…
Sep 11, 2020
Story
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Vibrational Spectroscopic Imaging in Cells, Tissues and Model Organisms
Here we present a webinar on the emerging applications of Stimulated Raman Scattering Microscopy, covering the following topics: Quantitative…
Apr 29, 2020
Webinar
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How to prepare samples for Stimulated Raman Scattering
Stimulated Raman Scattering (SRS) is an emerging microscopy technique that images the vibrations of chemical bonds within a specimen. It allows…
Feb 11, 2020
Tutorial
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Step by Step Guide to the Molecular Basics of CARS Microscopy
CARS (Coherent Anti-Stokes Raman Scattering) microscopy is a dye-free method which images structures by displaying the characteristic intrinsic…
Dec 16, 2019
Tutorial
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Stimulated Raman Scattering Microscopy Probes Neurodegenerative Disease
Despite decades of research, the molecular mechanisms underlying some of the most severe neurodegenerative diseases, such as Alzheimer’s or…
Nov 20, 2019
Story
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Improved tree-ring visualization using autofluorescence
Autofluorescence can be a very practical tool for the visualization of growth rings in wood, especially when these structures are hard to distinguish,…
Jul 23, 2019
Abstract
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Kaggle Competition for Multi-label Classification of Cell Organelles in Proteome Scale Human Protein Atlas Data
The Cell Atlas, a part of the Human Protein Atlas, was created by the group of Prof. Emma Lundberg at the SciLifeLab, KTH Royal Institute of…
Dec 09, 2018
Story
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You Shall Not Pass! Time-gated Detection Takes Care of Endogenous Fluorescence in Plant Research.
Yutaka Kodama is Associate Professor at the Biosciences Education Research Center, Utsunomiya University, Japan. He graduated from Saga University,…
Nov 13, 2018
Story
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Label-free in vivo Imaging of Myelinated Axons in Health and Disease with Spectral Confocal Reflectance Microscopy
We report a new technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no…
Jul 01, 2016
Abstract
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Third Harmonic Generation Microscopy – Label-Free 3D-Tissue Imaging and Blood Flow Characterization
THG microscopy as special variants of multiphoton microscopy. Third Harmonic Generation (THG) microscopy is a non-fluorescent multi-photon technique…
Apr 11, 2015
Abstract
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Unmask the Hidden without Probes: CARS
Fluorescence microscopy assumed a pivotal role in cell biology once it was possible to stain cell components selectively by fluorescing dyes. One of…
Mar 21, 2013
Story
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CARS Microscopy: Imaging Characteristic Vibrational Contrast of Molecules
Coherent anti-Stokes Raman scattering (CARS) microscopy is a technique that generates images based on the vibrational signatures of molecules. This…
Jul 16, 2012
Story
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An Introduction to CARS Microscopy
CARS overcomes the drawbacks of conventional staining methods by the intrinsic characteristics of the method. CARS does not require labeling because…
Nov 04, 2011
Tutorial
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Good Vibrations
In recent years, new molecular imaging techniques, such as coherent anti-Stokes Raman scattering microscopy (CARS), have been developed for rapid…
Apr 12, 2011
Story
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CARS and Confocal
The most important drawback of single-photon and multiphoton confocal microscopy is the need to label the specimen. CARS (Coherent Anti-Stokes Raman…
Nov 01, 2010
Tutorial

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Latest Articles

Formulated Product Characterization with SRS Microscopy

Coherent Raman Scattering Microscopy Publication List

How to Quantify Label-free Blood Flow

Vibrational Spectroscopic Imaging in Cells, Tissues and Model Organisms

How to prepare samples for Stimulated Raman Scattering

Step by Step Guide to the Molecular Basics of CARS Microscopy

Stimulated Raman Scattering Microscopy Probes Neurodegenerative Disease

Improved tree-ring visualization using autofluorescence

Kaggle Competition for Multi-label Classification of Cell Organelles in Proteome Scale Human Protein Atlas Data

You Shall Not Pass! Time-gated Detection Takes Care of Endogenous Fluorescence in Plant Research.

Label-free in vivo Imaging of Myelinated Axons in Health and Disease with Spectral Confocal Reflectance Microscopy

Third Harmonic Generation Microscopy – Label-Free 3D-Tissue Imaging and Blood Flow Characterization

Unmask the Hidden without Probes: CARS

CARS Microscopy: Imaging Characteristic Vibrational Contrast of Molecules

An Introduction to CARS Microscopy

Good Vibrations

CARS and Confocal