Science Lab

Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
Chicken cochlea tissue imaged with a THUNDER Imager using large volume computational clearing. Courtesy of Dr. Amanda Janesick, California, USA.

Development and Recovery of the Inner Ear

This article discusses how thick cochlear tissues of chicken embryos can be sharply imaged for studying inner-ear hair cell regeneration. Sensory hair cells perform important functions for hearing and…
Raw widefield and THUNDER image of a mouse dorsal root ganglion with tdTomato (red) expressed in the sensory neurons.

Fast, High-contrast 3D Imaging of Sensory Neurons

This article discusses how fast, high-contrast 3D imaging of dorsal root ganglion (DRG) tissue with a THUNDER Imager Tissue using large volume computational clearing (LVCC) allows sensory neurons to…
Raw widefield and THUNDER image of a mouse aorta

Molecular Mechanisms of Vascular Disease

This article discusses how the lamina, vascular cells, and nuclei of mouse aorta are more clearly resolved with a THUNDER Imager Tissue using Computational Clearing (CC) compared to conventional…
Raw widefield and THUNDER image of mouse brain showing D2-dopamine receptors.

Expression of D2-Dopamine Receptors in Neurons

This article discusses how D2-dopamine receptors (D2R) in the substantia-nigra of mouse brain can be more clearly revealed with a THUNDER Imager 3D Assay using Instant Computational Clearing (ICC)…
Images of mouse lung: (left) raw widefield and (right) after the THUNDER technology instant computational clearing (ICC). Courtesy of Dr. Ross Metzger, CA, USA.

Investigating Pulmonary Vascular Diseases

This article describes how the cellular and molecular programs governing the formation and maintenance of lung blood vessels, as well as what goes wrong with them when pulmonary vascular diseases…
THUNDER images of chick embryo brain with labelled neuronal progenitors: left) Raw widefield data and right) after computational clearing. Courtesy T. Sanders, University of Chicago, USA.

Deciphering Signaling Pathways in Developmental Biology

This article shows how sharp, rapid imaging of neuronal progenitors in chick embryos with a THUNDER Imager Model Organism and small volume computational clearing (SVCC) could help with the study of…

Visualizing retinal interactions to study eye diseases

This article shows how interactions between endothelial cells, blood vessels, microglia, and astrocytes in mouse retina can be studied efficiently with a THUNDER Imager 3D Cell Culture and Large…
Whole mouse embryo widefield data and LVCC

Cranial Nerve Development

This article demonstrates how fast, high-contrast imaging of mouse embryos with a THUNDER Imager 3D Cell Culture and Large Volume Computational Clearing (LVCC) enable the investigation of axonal…
Macroscopic extended depth of field images of C. elegans

Autophagy and Age-Related Pathologies

High-contrast imaging of the model organism C. elegans, a nematode, with the THUNDER Imager Model Organism using Small Volume Computational Clearing (SVCC) helps to better understand how autophagy and…
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