Science Lab

Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
Depth coding of endothelial cells in zebrafish eye. Courtesy of Basile Gurchenkov, Imaging Center of the IGBMC, Illkirch-Graffenstaden, France.

Gentle 3D Imaging of Biological Samples

For 3D imaging of biological samples, light sheet microscopy is a powerful and sensitive tool allowing you to measure (sub)cellular dynamics over long periods of time. Meanwhile, confocal microscopy,…
4D morphological information of Arabidopsis thaliana cotyledon pavement cells mapped using both direct water immersion observations and computational image analyses, including segmentation, surface modeling, virtual reality and morphometry.

Mapping 4D cell models with VR

Plant researchers Takumi Higaki and Hidenobu Mizuno have developed a framework to map leaf pavement cells in 4D using AI software with VR equipment.

High-resolution 3D Imaging to Investigate Tissue Ageing

Award-winning researcher Dr. Anjali Kusumbe demonstrates age-related changes in vascular microenvironments through single-cell resolution 3D imaging of young and aged organs.

Effects of Clearing Media on Tissue Transparency and Shrinkage

This study comprehensively evaluates the effects of different clearing media on tissue transparency and shrinkage by comparing freshly dissected dipteran fly brains with their cleared equivalents.…

Studying Autoimmune Disease

This article discusses how autoimmune diseases, like systemic lupus erythematosus (SLE), can be studied more efficiently using thick, 3D kidney tissue specimens visualized with a THUNDER Imager . SLE…

Studying Adipose Tissue Development and Expansion

This article discusses sharp, high-contrast imaging of whole mount adipose (fat) tissues specimens, which are thick and round (unsectioned), with a THUNDER Imager using Computational Clearing. Adipose…

Going beyond deconvolution

Widefield fluorescence microscopy is often used to visualize structures in life science specimens and obtain useful information. With the use of fluorescent proteins or dyes, discrete specimen…

Pore Scale Visualization of Drainage in 3D Porous Media by Confocal Microscopy

This work reports new interesting findings concerning porous media infiltration which have direct implications for the fields of energy (oil recovery) and environment (CO2 sequestration and aquifer…

3-Dimensional Imaging of Macroscopic Defects in Aluminum Alloys

The investigation of macroscale defects in aluminum (Al) alloys with a rapid 3-dimensional (3D) imaging approach is described in this report. Aluminum (Al) alloys play an important role in the…
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