Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Latest Articles

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Dissecting Proteomic Heterogeneity of the Tumor Microenvironment
This lecture will highlight cutting edge applications in applying laser microdissection and microscaled quantitative proteomics and phosphoproteomics…
Jun 15, 2021
Webinar
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20 Years of Leica Laser Microdissection
Phenotype-genotype correlations are key for insight. From Eye to Insight is therefore fitting perfectly to Leica Microsystems and in particular to…
May 10, 2021
Story
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How to improve your Biomarker Discovery Workflow with Laser Microdissection
Biomarkers can be used as indicators of certain diseases, such as cancer. The tumor microenvironment moved into the spotlight in this concern. It is…
Nov 16, 2020
Tutorial
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Microscopy in Virology
The coronavirus SARS-CoV-2, causing the Covid-19 disease effects our world in all aspects. Research to find immunization and treatment methods, in…
Jul 13, 2020
Story
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Observing the effect on transcription factor signaling and chromatin landscapes in cells infected with the human coronavirus 229E
Viral infection triggers an inflammatory cellular response which is characterized by altered gene expression. In this study, the influence of…
Jun 25, 2020
Abstract
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Medicinal Use of Qianhu Plant Roots
This study focused on tissue-specific metabolite profiling and comparison of various parts of bolting and unbolting Peucedanum praeruptorum Dunn…
Nov 06, 2019
Abstract
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Analysis of Tissue Sections Assisted by Fluorescence Laser Microdissection
Lectin microarray (LMA) is a highly sensitive technology used to obtain the global glycomic profiles of endogenous glycoproteins in biological samples…
Mar 26, 2019
Abstract
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How to improve your RNA Analysis Workflow with Laser Microdissection
Brain research: Single neuron excision for RNA analysis - Improve your workflow with laser microdissection - Parkinson’s disease is a common…
Mar 17, 2019
Story
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How to improve your Alzheimer Protein Analysis with Laser Microdissection
Brain Research: Collect pure starting material for proteomics - Improve your workflow with Laser Microdissection - Many brain diseases result from…
Mar 02, 2019
Story
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How to improve your DNA Mutation Analysis Workflow with Laser Microdissection
DNA mutations lead to abnormal proteins or missing functional proteins, which can cause cells to multiply uncontrollably and become cancerous. To find…
Feb 08, 2019
Story
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Live Cell Isolation by Laser Microdissection
Laser microdissection is a tool for the isolation of homogenous cell populations from their native niches in tissues to downstream molecular assays.…
Oct 16, 2018
Webinar
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Nanodroplet Processing Platform for Deep and Quantitative Proteome Proﬁling of 10–100 Mammalian Cells
Nanoscale or single-cell technologies are critical for biomedical applications. However, current mass spectrometry (MS)-based proteomic approaches…
Sep 12, 2018
Abstract
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Correlation of Phenotype and Genotype – microscopic samples and their biomolecular backgrounds
Seeing is believing, this is what makes microscopes, imaging systems, or box-type imagers so important for researchers in many different fields like…
Apr 20, 2017
Story
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MicroRNA Expression Profiling to Identify and Validate Reference Genes for the Relative Quantification of microRNA in Rectal Cancer
Application example for laser microdissection (LMD) - MicroRNAs (miRNAs) play important roles in regulating biological processes at the…
Dec 07, 2016
Abstract
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Workflows & Protocols: Plant Laser Microdissection
During Leica workshops for LMD users in Brazil, hosted by the Federal University of Paraná/UFPR (UFPR) at the Centro de Energia Nuclear na…
Jun 06, 2016
Story
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Workflows & Protocols: Laser Microdissection for Pathology and Cancer Research
Tumor development results from mutations in our DNA. For their deeper analysis, cancer researchers have to dissect the relevant tissue areas. Here we…
May 04, 2016
Story
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Workflows & Protocols: Connecting Microscopy and Molecular Biology in Neuroscience
The main topic during this course was how to apply laser microdissection in neuroscience. Leica specialists demonstrated why laser microdissection is…
Dec 04, 2015
Story
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Workflows & Protocols: How to Isolate Individual Chromosomes with Laser Microdissection
During the first Leica Workshop in Brazil, at the Centro de Energia Nuclear na Agricultura/USP (CENA), the participants learned how to prepare samples…
Dec 03, 2015
Story