Science Lab
Science Lab
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Adeno-associated Viral Vectors do not Efficiently Target Muscle Satellite Cells
Adeno-associated viral (AAV) vectors are becoming an important tool for gene therapy of numerous genetic and other disorders. Several recombinant AAV…
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Mirror-Enhanced Super-Resolution Microscopy
Axial excitation confinement beyond the diffraction limit is crucial to the development of next-generation, super-resolution microscopy. STimulated…
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The Actin Cytoskeleton Modulates the Activation of iNKT Cells by Segregating CD1d Nanoclusters on Antigen-Presenting Cells
The ability of invariant natural killer T (iNKT) cells to recognize endogenous antigens represents a distinct immune recognition strategy, which…
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Highly Selective Fluorescent and Colorimetric Probe for Live-cell Monitoring of Sulphide Based on Bioorthogonal Reaction
H2S is the third endogenously generated gaseous signaling compound and has also been known to involve a variety of physiological processes. To better…
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Translation Microscopy (TRAM) for Super-Resolution Imaging
Super-resolution microscopy is transforming our understanding of biology but accessibility is limited by its technical complexity, high costs and the…
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Label-free in vivo Imaging of Myelinated Axons in Health and Disease with Spectral Confocal Reflectance Microscopy
We report a new technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no…
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Two-Photon Excitation STED Microscopy with Time-Gated Detection
We report on a novel two-photon excitation stimulated emission depletion (2PE-STED) microscope based on time-gated detection. The time-gated detection…
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Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent
Super-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical aberrations. Here,…
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Cryo-electron Microscopy of Tubular Arrays of HIV-1 Gag Resolves Structures Essential for Immature Virus Assembly
HIV-1 undergoes a two-step assembly process. First, an immature noninfectious particle is assembled, which leaves the infected cell. Second, the…
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Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens
Transparent zebrafish embryos have proved useful model hosts to visualize and functionally study interactions between innate immune cells and…
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How to Combine STED and CLARITY
Previously, the preferred way to study the subtlest elements of the kidney, such as foot processes and the slit diaphragm has been by the use of…
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A Healthy Dose of Interferometry
Although interferometry may once have been dismissed by the medical community because of its inability to see inside the human body, its application…
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TEM Sample Preparation Made Easy - Prepare TEM Specimen by Broad Beam Argon Ion Milling
Quantitative and analytical analysis at high spatial resolution places stringent demands on the quality of the produced TEM specimens. Pristine and…
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Super-Resolution Microscopy of the Synaptic Active Zone
At the presynaptic active zone (AZ) a variety of specialized proteins are assembled to complex architectures, which set the basis for speed, precision…
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Color Infidelity: Why Using a Light Source Incorrectly is Cheating on your Data
There are many influences on color in the imaging process including lighting, optics, sensor, and monitor, and ultimately print. The first, and…
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The Value of Intraoperative OCT Imaging in Vitreoretinal Surgery
The role of iOCT in vitreoretinal surgery continues to be defined by active research and enhancements to integrative technologies. Further research is…
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Handheld Optical Coherence Tomography During Sedation in Young Children With Optic Pathway Gliomas
Monitoring young children with optic pathway gliomas (OPGs) for visual deterioration can be difficult owing to age-related noncompliance. Optical…
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What do you Call a Drosophila who Likes to Drink? A Bar Fly!
The thought of a Drosophoila headed to the local bar for a drink creates a funny joke, but after long hours of sorting flies under a microscope that…