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Science Lab

Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Stem Cells in the Aging Process – the Signal Protein p53 as "Guardian of the Genome"

The physiological process of aging is an elementary part of life. The processes responsible for the aging process and the effect they have is one of the key focuses of biomedical research. Dr. Yvonne…
John B. Gurdon

Nobel Prize 2012 in Physiology or Medicine for Stem Cell Research

The Nobel Prize recognizes two scientists who discovered that mature, specialised cells can be reprogrammed to become immature cells capable of developing into all tissues of the body. Their findings…
CARS image of cellulose fibers. The fibers are visualized through the C–H vibrations of the polyglucan chains in cellulose.

CARS Microscopy: Imaging Characteristic Vibrational Contrast of Molecules

Coherent anti-Stokes Raman scattering (CARS) microscopy is a technique that generates images based on the vibrational signatures of molecules. This imaging methods does not require labeling, yet…
Jellyfish Aequorea Victoria

Fluorescent Proteins - From the Beginnings to the Nobel Prize

Fluorescent proteins are the fundament of recent fluorescence microscopy and its modern applications. Their discovery and consequent development was one of the most exciting innovations for life…

Super-Resolution GSDIM Microscopy

The nanoscopic technique GSDIM (ground state depletion microscopy followed by individual molecule return) provides a detailed image of the spatial arrangement of proteins and other biomolecules within…

Metallography with Color and Contrast

The examination of microstructure morphology plays a decisive role in materials science and failure analysis. There are many possibilities of visualizing the real structures of materials in the light…
An ID card which has been tampered with by counterfeiters who inserted a hologram.

Is that Document Genuine or Fake? How do They Identify Fake Documents?

This article shows how forensic experts use microscopy for analysis to identify counterfeit, fake documents, such as ID cards, passports, visas, certificates, etc. Then they know if it is genuine or…
Fluorescence microscope image of a life-science specimen

An Introduction to Fluorescence

This article gives an introduction to fluorescence and photoluminescence, which includes phosphorescence, explains the basic theory behind them, and how fluorescence is used for microscopy.
Cochlea implant. Illustration: © MED-EL.

Cochlea Implants for Deaf and Severely Hard of Hearing

The cochlea implant (CI) replaces the function of the outer ear, the middle ear and the ­cochlea of the inner ear. Basically, it consists of an external unit comprising a microphone, speech processor,…
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