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Science Lab

Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
The intraoperative OCT showed the ellipsoid had separated from the inner retina with focal attachment to the retinal pigment epithelium (RPE). Images provided by Mr. Robert Henderson

Utility of Intraoperative OCT in Sub-Retinal Gene Therapy

Discover a case study on the use of intraoperative OCT for pediatric gene therapy and how it supports bleb placement and verifying the foveal contour.
Raw widefield and THUNDER image of calcium transients in Drosophila embryos. Courtesy A. Carreira-Rosario, Clandinin laboratory, California, USA.

Central Nervous System (CNS) Development and Activity in Organisms

This article shows how studying central nervous system (CNS) development in Drosophila-melanogaster embryos expressing a GCaMP calcium indicator in the neurons can be improved with a THUNDER Imager.
Diffuse retinal degeneration with relative macular sparing.

Ophthalmic Gene Therapy Subretinal Injection

Case study on the use of intraoperative OCT for Leber congenital amaurosis macular repair and ophthalmic gene therapy subretinal injection.
Raw widefield and THUNDER image of transversal mouse adult fiber lens section. Courtesy N. Houssin, Plagemen lab, Ohio State University, Columbus, USA.

Studying Ocular Birth Defects

This article discusses how lens formation and ocular birth defects can be studied with sharp widefield microscopy images which are acquired rapidly. The mouse ocular lens is used as a model to study…
Images of smooth muscle cells during wound healing. Courtesy L.S. Shankman, Ph.D., University of Virginia.

Studying Wound Healing of Smooth Muscle Cells

This article discusses how wound healing of cultured smooth muscle cells (SMCs) in multiwell plates can be reliably studied over time with less effort using a specially configured Leica inverted…
GLOW800 Augmented Reality fluorescence in Moyamoya disease treatment

How AR Helps in the Surgical Treatment of Moyamoya Disease

Moyamoya disease is a rare chronic occlusive cerebrovascular disorder characterized by progressive stenosis in the terminal portion of the internal carotid artery and an abnormal vascular network at…
Colon Adenocarcinoma. Four biomarkers shown: NaK, CD8, CD4 and Sma1. T-Cells shown in red and yellow.

Multiplex Imaging Reveals Survival Markers after Cancer Care

Colorectal cancer is a high incidence and high mortality cancer. Currently, postoperative chemotherapy benefits only a minority of patients, and thus, new tools are necessary to screen patients and…
Clinical case: radial forearm free flap preparation with prelaminated urethra and phalloplasty anastomosis

Using GLOW800 AR in Radial Forearm Flap Free Phalloplasty

In this video, Chief Microsurgeon Professor Küntscher and his team perform a radial forearm free flap phalloplasty and use ICG fluorescence imaging to show the blood flow in the whole flap from the…
Raw widefield and THUNDER image of a mouse dorsal root ganglion with tdTomato (red) expressed in the sensory neurons.

Fast, High-contrast 3D Imaging of Sensory Neurons

This article discusses how fast, high-contrast 3D imaging of dorsal root ganglion (DRG) tissue with a THUNDER Imager Tissue using large volume computational clearing (LVCC) allows sensory neurons to…
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